ID D7FRT1_ECTSI Unreviewed; 2060 AA.
AC D7FRT1;
DT 10-AUG-2010, integrated into UniProtKB/TrEMBL.
DT 10-AUG-2010, sequence version 1.
DT 03-MAY-2023, entry version 57.
DE SubName: Full=Long-chain acyl-CoA synthetase {ECO:0000313|EMBL:CBJ30872.1};
GN ORFNames=Esi_0219_0017 {ECO:0000313|EMBL:CBJ30872.1};
OS Ectocarpus siliculosus (Brown alga) (Conferva siliculosa).
OC Eukaryota; Sar; Stramenopiles; Ochrophyta; PX clade; Phaeophyceae;
OC Ectocarpales; Ectocarpaceae; Ectocarpus.
OX NCBI_TaxID=2880 {ECO:0000313|EMBL:CBJ30872.1, ECO:0000313|Proteomes:UP000002630};
RN [1] {ECO:0000313|EMBL:CBJ30872.1, ECO:0000313|Proteomes:UP000002630}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Ec32 / CCAP1310/4 {ECO:0000313|Proteomes:UP000002630};
RX PubMed=20520714; DOI=10.1038/nature09016;
RA Cock J.M., Sterck L., Rouze P., Scornet D., Allen A.E., Amoutzias G.,
RA Anthouard V., Artiguenave F., Aury J.M., Badger J.H., Beszteri B.,
RA Billiau K., Bonnet E., Bothwell J.H., Bowler C., Boyen C., Brownlee C.,
RA Carrano C.J., Charrier B., Cho G.Y., Coelho S.M., Collen J., Corre E.,
RA Da Silva C., Delage L., Delaroque N., Dittami S.M., Doulbeau S., Elias M.,
RA Farnham G., Gachon C.M., Gschloessl B., Heesch S., Jabbari K., Jubin C.,
RA Kawai H., Kimura K., Kloareg B., Kupper F.C., Lang D., Le Bail A.,
RA Leblanc C., Lerouge P., Lohr M., Lopez P.J., Martens C., Maumus F.,
RA Michel G., Miranda-Saavedra D., Morales J., Moreau H., Motomura T.,
RA Nagasato C., Napoli C.A., Nelson D.R., Nyvall-Collen P., Peters A.F.,
RA Pommier C., Potin P., Poulain J., Quesneville H., Read B., Rensing S.A.,
RA Ritter A., Rousvoal S., Samanta M., Samson G., Schroeder D.C., Segurens B.,
RA Strittmatter M., Tonon T., Tregear J.W., Valentin K., von Dassow P.,
RA Yamagishi T., Van de Peer Y., Wincker P.;
RT "The Ectocarpus genome and the independent evolution of multicellularity in
RT brown algae.";
RL Nature 465:617-621(2010).
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DR EMBL; FN648397; CBJ30872.1; -; Genomic_DNA.
DR STRING; 2880.D7FRT1; -.
DR EnsemblProtists; CBJ30872; CBJ30872; Esi_0219_0017.
DR eggNOG; KOG3628; Eukaryota.
DR InParanoid; D7FRT1; -.
DR OMA; HETEFES; -.
DR OrthoDB; 101227at2759; -.
DR Proteomes; UP000002630; Chromosome LG05.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR Gene3D; 3.30.300.30; -; 1.
DR Gene3D; 1.10.1200.10; ACP-like; 1.
DR Gene3D; 2.160.10.10; Hexapeptide repeat proteins; 1.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR InterPro; IPR011004; Trimer_LpxA-like_sf.
DR PANTHER; PTHR22754:SF32; DISCO-INTERACTING PROTEIN 2; 1.
DR PANTHER; PTHR22754; DISCO-INTERACTING PROTEIN 2 DIP2 -RELATED; 1.
DR Pfam; PF00501; AMP-binding; 1.
DR Pfam; PF00550; PP-binding; 1.
DR SMART; SM00823; PKS_PP; 1.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR SUPFAM; SSF47336; ACP-like; 1.
DR SUPFAM; SSF51161; Trimeric LpxA-like enzymes; 2.
DR PROSITE; PS00455; AMP_BINDING; 1.
DR PROSITE; PS50075; CARRIER; 1.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000002630};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 1269..1290
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1343..1369
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1389..1408
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1558..1577
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1589..1612
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1797..1818
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1838..1864
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1144..1219
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT REGION 406..442
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 610..633
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1063..1145
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1887..1907
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1106..1133
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1893..1907
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2060 AA; 224685 MW; 4FCD03ACC5DA1682 CRC64;
MTMRHLAAKI FAEEVGCDWL TPSQWGMPVA GDGSGASVYC HSAATYDEQR RGFGNATKDE
AEIMVHRCSV VNWPEYFNLN ASSVELPANC TFRVVEADTS RNHDLEMALK ETDANGFDNL
GWDRLKIVLR QPHASSNFLA SLGSWDGWKR EVVRKVLRQF RENFHQSPRP WYNDEPECGY
EESELNFALH VRMGDRRELE GVTPEYFSLL EGFMATVTQA VVEREQAAPM FHVFSEALYP
CPFPENATFT EFPFWPVERD QVSVCPRNAA EQDGPASRPD TFRVEGRPVL LHLGRNAAEA
LSCMVHADGL LMGCSTFGQL AGVLNGDGIS FFSTECGGHG APLQSKMIPP LAVAERGRMW
VPIAGSWRDP VLRAKHVFSA VLDELLKRKQ GSTRVPRGRR TSLRWSLHQR SGRRQRSSFF
EKGDKMTPVP SDGRGGDDSY QHVSTRSSGT FLQAIARSIN KIPEDQVFGR WYNSKGQVES
TRTFHGVWVA SGEIAHLLRV EWGLSKGDRV VLAFDFGLRF FAVFLGCLRA GIIAVPVYPP
NPATLKRSLK KLQLIVDSCA PKMVLVCPLV NKLRLASKLR AVATGKSGWP DLPYHCPDVK
EENIPTGGMS SATVGWRSGG GKSADVKRTR PSFDDPTIKP QDVAFLQFTS GSTSDPKGVM
LTYGNLTHNI GVIVNSSNAQ IAERGGVADG QRTWFSWLPT FHDMGLIQGT LTPFVAGWTA
AYCSPITFMR RPLVWLELMS KEKSQMTAAP DFAFRLCVRK WEEMSPENRT ALHLDLKHIM
FMQNAAEPVR ASTVRDFAEA FAAVGLPGYA SNAAYGLAEH TVGCASSSSN PGGGSLRHIP
DERLQASGDI HFSAGLHMDI KIVDPETCRE VPTGETGEMW VSSDSVAAGY WGKPELTQGT
FRARIKCDSA DGSPPPPWAN SEFLRTGDLC RVDAEGLLYV EGRLKDLVIV AGRNIYPQDI
EFVAQDASPL VRPGCIAVFS ETELGGGLEI VMEVRSVSKK NTHAVTEALE AVRRSVMSES
GLAPSRVVAI KERTIPKTTS GKIQRRKTRA ALHAGALEVV QELRFDPVET PPPAVRGPTP
LSDREESSST APTAVPAAER ALHRASSSKL SPQTADGNTS MAPKNSSDAE TPRGNTERPP
ERQAPAELCV KDVIDIVQSA TGVSCIGESD DLLDLGVDSL MSVGISKDLS EASGCELPQE
LVFTHPTVTL IAEFISSAVQ SRQASTRASD LSAAGVSSMP THMGGLDCPG GSHLKDLGEQ
WTTGPMQGWA FRLSQTILLA LVLVQIFVAL QPARHYWRYI NELALTGSFG GYNKQPWLYV
DLPVFGGGGG GGGSAEESSK MRVLGLLGAL SPIIWFACFT AIVIVTKLLL IGGYPQVRVP
LGTRAYLSWW YMNTMLNVWE SVGGTWLLDT KLIIFIYRCM GAQIAWTASI SVFVREFDSV
EVQEGAKVDG NLYVRRFEAS YMDVAPIIIG KGADIRTGSV VYGGTSVGDH WAALRMAYCG
IDSSITDGRI VRFACTQPHS TWEGHPAKET SQAHDSMVLD VPGTRVTTLC LTELAKQISI
LCTLVATTAM TYIPTILYES TGLSENFRYA LLVEVVFLVA GVPSQLALYT VLLKWVLAGR
VTEGSYKPSV FQTWRRWYLG RLNTFVFAYL HVFNQCPRYE WWSAALGMKV GRGSVVLLEE
FNPEDAHLIQ IGCRSHIGYP RLSVDRPTGR GTEREKKAIS IGSKALLGFG VHIGAGCTVG
NGAMLGGYSK LRPGEHLTDG SVTMCDQQSA FQFGGSAPTS VPRDIHDDPR ETVKANVIDA
ACTLGACSLN ILALVASFEA TKLAASLWSR GDSIDTRVVV LSAVALIVWA LASAVLLAVF
KWVFVGNFRL MSTAGTQREI SARVGPRSTD IEKGSGGGQQ EGQRRKTNKL TASQVMRWRW
MQRFVYFSLF EPYIVNTVLK GTWLLNVWLR LMGADVSMGA LILGKVSDHG MVKVCKGSVV
AGVLYGHRAT FVDGIWSLEL APARVGERGV VHAHTGSWCT EMGAGSTLTA GSATLSGQVL
QAGEVFGGRP PQKLCGSWAW
//
