ID D7G720_ECTSI Unreviewed; 1638 AA.
AC D7G720;
DT 10-AUG-2010, integrated into UniProtKB/TrEMBL.
DT 10-AUG-2010, sequence version 1.
DT 27-MAR-2024, entry version 64.
DE RecName: Full=Nephrocystin-3 {ECO:0000256|ARBA:ARBA00040387};
GN ORFNames=Esi_0008_0157 {ECO:0000313|EMBL:CBJ25713.1};
OS Ectocarpus siliculosus (Brown alga) (Conferva siliculosa).
OC Eukaryota; Sar; Stramenopiles; Ochrophyta; PX clade; Phaeophyceae;
OC Ectocarpales; Ectocarpaceae; Ectocarpus.
OX NCBI_TaxID=2880 {ECO:0000313|EMBL:CBJ25713.1, ECO:0000313|Proteomes:UP000002630};
RN [1] {ECO:0000313|EMBL:CBJ25713.1, ECO:0000313|Proteomes:UP000002630}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Ec32 / CCAP1310/4 {ECO:0000313|Proteomes:UP000002630};
RX PubMed=20520714; DOI=10.1038/nature09016;
RA Cock J.M., Sterck L., Rouze P., Scornet D., Allen A.E., Amoutzias G.,
RA Anthouard V., Artiguenave F., Aury J.M., Badger J.H., Beszteri B.,
RA Billiau K., Bonnet E., Bothwell J.H., Bowler C., Boyen C., Brownlee C.,
RA Carrano C.J., Charrier B., Cho G.Y., Coelho S.M., Collen J., Corre E.,
RA Da Silva C., Delage L., Delaroque N., Dittami S.M., Doulbeau S., Elias M.,
RA Farnham G., Gachon C.M., Gschloessl B., Heesch S., Jabbari K., Jubin C.,
RA Kawai H., Kimura K., Kloareg B., Kupper F.C., Lang D., Le Bail A.,
RA Leblanc C., Lerouge P., Lohr M., Lopez P.J., Martens C., Maumus F.,
RA Michel G., Miranda-Saavedra D., Morales J., Moreau H., Motomura T.,
RA Nagasato C., Napoli C.A., Nelson D.R., Nyvall-Collen P., Peters A.F.,
RA Pommier C., Potin P., Poulain J., Quesneville H., Read B., Rensing S.A.,
RA Ritter A., Rousvoal S., Samanta M., Samson G., Schroeder D.C., Segurens B.,
RA Strittmatter M., Tonon T., Tregear J.W., Valentin K., von Dassow P.,
RA Yamagishi T., Van de Peer Y., Wincker P.;
RT "The Ectocarpus genome and the independent evolution of multicellularity in
RT brown algae.";
RL Nature 465:617-621(2010).
CC -!- SIMILARITY: Belongs to the TUBGCP family.
CC {ECO:0000256|ARBA:ARBA00010337}.
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DR EMBL; FN649035; CBJ25713.1; -; Genomic_DNA.
DR STRING; 2880.D7G720; -.
DR EnsemblProtists; CBJ25713; CBJ25713; Esi_0008_0157.
DR eggNOG; KOG1840; Eukaryota.
DR eggNOG; KOG2000; Eukaryota.
DR eggNOG; KOG4658; Eukaryota.
DR InParanoid; D7G720; -.
DR OrthoDB; 55927at2759; -.
DR Proteomes; UP000002630; Chromosome LG02.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005871; C:kinesin complex; IEA:InterPro.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR GO; GO:0043015; F:gamma-tubulin binding; IEA:InterPro.
DR Gene3D; 1.20.120.1900; Gamma-tubulin complex, C-terminal domain; 1.
DR Gene3D; 1.10.8.430; Helical domain of apoptotic protease-activating factors; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 5.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR042197; Apaf_helical.
DR InterPro; IPR040457; GCP_C.
DR InterPro; IPR042241; GCP_C_sf.
DR InterPro; IPR041470; GCP_N.
DR InterPro; IPR002151; Kinesin_light.
DR InterPro; IPR002182; NB-ARC.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR45641:SF1; NEPHROCYSTIN-3; 1.
DR PANTHER; PTHR45641; TETRATRICOPEPTIDE REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_6G03870); 1.
DR Pfam; PF04130; GCP_C_terminal; 1.
DR Pfam; PF17681; GCP_N_terminal; 1.
DR Pfam; PF00931; NB-ARC; 1.
DR Pfam; PF13374; TPR_10; 4.
DR Pfam; PF13424; TPR_12; 6.
DR PRINTS; PR00381; KINESINLIGHT.
DR SMART; SM00028; TPR; 15.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF48452; TPR-like; 5.
DR PROSITE; PS50005; TPR; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Reference proteome {ECO:0000313|Proteomes:UP000002630};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW TPR repeat {ECO:0000256|ARBA:ARBA00022803, ECO:0000256|PROSITE-
KW ProRule:PRU00339}; Wnt signaling pathway {ECO:0000256|ARBA:ARBA00022687}.
FT DOMAIN 262..507
FT /note="NB-ARC"
FT /evidence="ECO:0000259|Pfam:PF00931"
FT REPEAT 1174..1207
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT DOMAIN 1306..1380
FT /note="Gamma tubulin complex component protein N-terminal"
FT /evidence="ECO:0000259|Pfam:PF17681"
FT DOMAIN 1385..1595
FT /note="Gamma tubulin complex component C-terminal"
FT /evidence="ECO:0000259|Pfam:PF04130"
FT REGION 1265..1284
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1638 AA; 179107 MW; 133EAD1C59B1464A CRC64;
MYMTIVVQQL GDQRQAAGVR DGTGGEMQRA PASGDQAGLA AAAVVEPTTV ERLDHVGKLL
AEKKPWPAFL HIGARATEEW EACPTPVQEA LAWMTTSAVG VLGVASVGPL VPVCEAFKAL
IEAAEGAAEC QDKLQSLVSQ CAFLATVLIQ HGRAVGPLAQ VQKPIQDFVA TTNELAGFAA
RWAKGGKCRA FFCHRPDLSA LAGFEECLRR IRSDIALVDG LEHHQSFLAA LPSLLPPSLP
DMAAVPAGAL ELPSSSYVER AAVQEVADGL TAPEESRAPY TVVGMGGGGK SVLASAVVRK
PSVREHFRGG IFWVRVGRGA KSSLLALLQG LARDVGAAPT DAPCGVPRVL DSLEQVRQHL
AAVTSTGTSQ RLVVLDDVWE REVVDAFVPL GFKVLLTTRD RSVVGVPAGR LELGDVTEEE
ALELLRKTSG AVGQPGDDVR TKMTKVVALC GHLPLVLAIA GSMSVVRGKG LTAVAWEELA
KELENVAKKM RARGEQSSSM KVVLETSFDS LAVRKQEEFL KMAVLAAGAL APIEMLRNLW
EIEDAEGTRD DAEGLVSKCL LHAVGGGGYR VHDLVLEFAK TSIRAEEETV KKATALQAQY
LGRLDVLESY GDPEHGTGDQ GLFFLDALWR SVEKLSGDPG LEVASYRASL EELESCEATE
AVATSYGSVG FLFNIQSKYA EAEPLYERSR AIQEKVLGPE HPHVATSLNN RGKYDEAGPL
YERSLAIHEK LYGPDHLAVA TALNNRAGLL RAQGKYDDAE PLYVRAIVIG EKALGPEHPD
VAVQLNNRAG LLRAQGKYDD AEPLYVRAIV IGEKALGPEH PDVAVQLNNR AELLRAQGKY
EEAEPLYERS QAVREKVLGP EHPDVAVSLN NRGKFAEAEP LHRRATKIWE TALGPEHPDV
ATALNNRGKF AEAEPLYRRA TEIWETALGP EHPNVATALN NRAVLLDSQG KYEEAEPLYE
RSQAIREKVL GPEHPAVATV LNNRAGLLES QGKHSEAESL YERCQAINEK ALGPEHPSLA
TTFNNRAGLL QAQGKYSEAE PLYERCQAIK EKALGPEHPS LATTLNNRGK YDEADPLYLR
AIEIGEKTLG PDHPDLATRL NNRAELLRAQ GKYEDADPLY VRVLEILGAT VGEQHPNYAS
ALNNRGKHSE AEPLYERCQA IEEKALGPEH PSLARTLNNR AGLLRAQGKY DEAEPLYRRS
LAIDEKVYGP DHPEVATDLN NWAELLIAQE KHTEALPLLE RALRIRTKKL GWTEEEHHTV
LYRSTWGSRR RSPRRTGRKS PRDRSAYLVE HEALVAREAS NGSNGEVAVK IVTIGKAINF
LRHLCGNSEW ITGPMAKASS LALLAAAQAT TLEYGNTTSL RAVVESCSAL TKSRLVHLML
GPYRLKSHLR VLKKFLLHGQ GDLMLTLIEV LGPELDKKAT VICRHNVMGI VEGVIKTSAI
LQDEAGDVAI RIGVKISTGY DFVRVAMPAS PSLRGWDVFS LKYDVGAPVS TVVTEEVLVE
YPRFFHLLWR IKRAEWSLAS AWRLHTSATH VRLEQALLEL KGALHRCSLV RGQMFSLTTK
LSNYMMFEVL ETSWGTLQHI YNRAELLRVQ EKHTEAFPLL ERALRIRTKK LGVRTRWKTL
AALAVTADAM KKTGEKLA
//
