ID D7GX04_9FIRM Unreviewed; 579 AA.
AC D7GX04;
DT 10-AUG-2010, integrated into UniProtKB/TrEMBL.
DT 10-AUG-2010, sequence version 1.
DT 27-MAR-2024, entry version 42.
DE RecName: Full=Rqc2 homolog RqcH {ECO:0000256|HAMAP-Rule:MF_00844};
DE Short=RqcH {ECO:0000256|HAMAP-Rule:MF_00844};
GN Name=rqcH {ECO:0000256|HAMAP-Rule:MF_00844};
GN ORFNames=CK3_28400 {ECO:0000313|EMBL:CBL42346.1};
OS butyrate-producing bacterium SS3/4.
OC Bacteria; Bacillota; Clostridia; Eubacteriales.
OX NCBI_TaxID=245014 {ECO:0000313|EMBL:CBL42346.1, ECO:0000313|Proteomes:UP000008961};
RN [1] {ECO:0000313|EMBL:CBL42346.1, ECO:0000313|Proteomes:UP000008961}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SS3/4 {ECO:0000313|EMBL:CBL42346.1,
RC ECO:0000313|Proteomes:UP000008961};
RG metaHIT consortium -- http://www.metahit.eu/;
RA Pajon A., Turner K., Parkhill J., Duncan S., Flint H.;
RT "The genome sequence of Clostridiales sp. SS3/4.";
RL Submitted (MAR-2010) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:CBL42346.1, ECO:0000313|Proteomes:UP000008961}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SS3/4 {ECO:0000313|EMBL:CBL42346.1,
RC ECO:0000313|Proteomes:UP000008961};
RA Pajon A.;
RL Submitted (MAR-2010) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Part of the ribosome quality control system (RQC). Recruits
CC Ala-charged tRNA and directs the elongation of stalled nascent chains
CC on 50S ribosomal subunits, leading to non-templated C-terminal Ala
CC extensions (Ala tail). The Ala tail promotes nascent chain degradation.
CC May add between 1 and at least 8 Ala residues. Binds to stalled 50S
CC ribosomal subunits. {ECO:0000256|HAMAP-Rule:MF_00844}.
CC -!- SUBUNIT: Associates with stalled 50S ribosomal subunits.
CC {ECO:0000256|HAMAP-Rule:MF_00844}.
CC -!- SIMILARITY: Belongs to the NEMF family. {ECO:0000256|HAMAP-
CC Rule:MF_00844}.
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DR EMBL; FP929062; CBL42346.1; -; Genomic_DNA.
DR AlphaFoldDB; D7GX04; -.
DR KEGG; bprs:CK3_28400; -.
DR PATRIC; fig|245014.3.peg.1392; -.
DR HOGENOM; CLU_022481_2_1_9; -.
DR BioCyc; BBAC245014:G1314-2463-MONOMER; -.
DR Proteomes; UP000008961; Chromosome.
DR GO; GO:0043023; F:ribosomal large subunit binding; IEA:UniProtKB-UniRule.
DR GO; GO:0000049; F:tRNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0072344; P:rescue of stalled ribosome; IEA:UniProtKB-UniRule.
DR Gene3D; 1.10.8.50; -; 1.
DR Gene3D; 2.30.310.10; ibrinogen binding protein from staphylococcus aureus domain; 1.
DR HAMAP; MF_00844_B; RqcH_B; 1.
DR InterPro; IPR008532; NFACT_RNA-bd.
DR InterPro; IPR010979; Ribosomal_uS13-like_H2TH.
DR InterPro; IPR043682; RqcH_bacterial.
DR PANTHER; PTHR15239; NUCLEAR EXPORT MEDIATOR FACTOR NEMF; 1.
DR PANTHER; PTHR15239:SF6; RIBOSOME QUALITY CONTROL COMPLEX SUBUNIT NEMF; 1.
DR Pfam; PF05670; NFACT-R_1; 1.
DR Pfam; PF05833; NFACT_N; 1.
DR SUPFAM; SSF46946; S13-like H2TH domain; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|HAMAP-Rule:MF_00844};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917, ECO:0000256|HAMAP-
KW Rule:MF_00844};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|HAMAP-
KW Rule:MF_00844};
KW tRNA-binding {ECO:0000256|ARBA:ARBA00022555, ECO:0000256|HAMAP-
KW Rule:MF_00844}.
FT DOMAIN 462..554
FT /note="NFACT RNA-binding"
FT /evidence="ECO:0000259|Pfam:PF05670"
FT COILED 392..419
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00844"
SQ SEQUENCE 579 AA; 65867 MW; 64473D7D95ED6997 CRC64;
MAFDGIVIAN LVRDLNDKIV SGRISKIAQP EKDELLFTIK GNRENVRLLV SANASLPLLY
FTANNKPSPM TAPNFCMLLR KHIANGRIIS VTQPGLERIV RIEVEHLDEM GDLRRKFIVI
ELMGKHSNII FCDENNVILD SIKHISAQVS SVREVLPGRD YFIPHSGEKK NPLTITETEF
KELLHSTPQN LSKALYMDLT GLSPVVAAEI CHLASLDGDI SAKEFSDAEL THLFHAFNWI
MDDIREGNFT PNIIYEGEKP IEFAAVPLTM MEGGNYRTVK FDSISELLER YYAEKNTVSR
IHQKSTDLRK IISNALERSV RKLDLQTKQL KDTEKREKYR IYGELLNTYG YGLSGGEKSL
KCLNYYDNTE ITIPLDPTMT AQENAKRYFD KYNKQKRTYE AVTEQLAQTK AEIDHLESIS
TSMDIARLEE DLVQIKEELT EYGYIKRHYT GGKKVKITSR PFHYLSSDGF HIYVGKNNYQ
NEELDFKFAN GGDWWFHAKG IPGSHVIVKT EGKELPDRVF EEAGALAAYY SKGRGNEKVE
VDYIQRKNLK KVPGAAPGFV VYHTNYSLMA VPGITVQEV
//
