ID   D7IH74_9BACE            Unreviewed;       499 AA.
AC   D7IH74;
DT   10-AUG-2010, integrated into UniProtKB/TrEMBL.
DT   10-AUG-2010, sequence version 1.
DT   24-JAN-2024, entry version 34.
DE   SubName: Full=Acetyl-CoA hydrolase/transferase family protein {ECO:0000313|EMBL:EFI02995.1};
GN   ORFNames=HMPREF9007_03734 {ECO:0000313|EMBL:EFI02995.1};
OS   Bacteroides sp. 1_1_14.
OC   Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Bacteroidaceae;
OC   Bacteroides.
OX   NCBI_TaxID=469585 {ECO:0000313|EMBL:EFI02995.1, ECO:0000313|Proteomes:UP000003951};
RN   [1] {ECO:0000313|EMBL:EFI02995.1, ECO:0000313|Proteomes:UP000003951}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=1_1_14 {ECO:0000313|EMBL:EFI02995.1,
RC   ECO:0000313|Proteomes:UP000003951};
RG   The Broad Institute Genome Sequencing Platform;
RA   Ward D., Earl A., Feldgarden M., Gevers D., Young S.K., Zeng Q.,
RA   Koehrsen M., Alvarado L., Berlin A., Bochicchio J., Borenstein D.,
RA   Chapman S.B., Chen Z., Engels R., Freedman E., Gellesch M., Goldberg J.,
RA   Griggs A., Gujja S., Heilman E., Heiman D., Hepburn T., Howarth C., Jen D.,
RA   Larson L., Mehta T., Park D., Pearson M., Roberts A., Saif S., Shea T.,
RA   Shenoy N., Sisk P., Stolte C., Sykes S., Thomson T., Walk T., White J.,
RA   Yandava C., Strauss J., Daigneault M., McDonald J., Ambrose C.E.,
RA   Allen-Vercoe E., Haas B., Nusbaum C., Birren B.;
RT   "The Genome Sequence of Bacteroides sp. strain 1_1_14.";
RL   Submitted (MAR-2010) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the acetyl-CoA hydrolase/transferase family.
CC       {ECO:0000256|ARBA:ARBA00009632}.
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DR   EMBL; GG774709; EFI02995.1; -; Genomic_DNA.
DR   AlphaFoldDB; D7IH74; -.
DR   HOGENOM; CLU_019748_3_0_10; -.
DR   Proteomes; UP000003951; Unassembled WGS sequence.
DR   GO; GO:0008775; F:acetate CoA-transferase activity; IEA:InterPro.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006083; P:acetate metabolic process; IEA:InterPro.
DR   GO; GO:0006084; P:acetyl-CoA metabolic process; IEA:InterPro.
DR   Gene3D; 3.30.750.70; 4-hydroxybutyrate coenzyme like domains; 1.
DR   Gene3D; 3.40.1080.20; Acetyl-CoA hydrolase/transferase C-terminal domain; 1.
DR   Gene3D; 3.40.1080.10; Glutaconate Coenzyme A-transferase; 1.
DR   InterPro; IPR026888; AcetylCoA_hyd_C.
DR   InterPro; IPR038460; AcetylCoA_hyd_C_sf.
DR   InterPro; IPR046433; ActCoA_hydro.
DR   InterPro; IPR003702; ActCoA_hydro_N.
DR   InterPro; IPR037171; NagB/RpiA_transferase-like.
DR   InterPro; IPR017821; Succinate_CoA_transferase.
DR   NCBIfam; TIGR03458; YgfH_subfam; 1.
DR   PANTHER; PTHR43609; ACETYL-COA HYDROLASE; 1.
DR   PANTHER; PTHR43609:SF1; ACETYL-COA HYDROLASE; 1.
DR   Pfam; PF13336; AcetylCoA_hyd_C; 1.
DR   Pfam; PF02550; AcetylCoA_hydro; 1.
DR   SUPFAM; SSF100950; NagB/RpiA/CoA transferase-like; 2.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000313|EMBL:EFI02995.1};
KW   Transferase {ECO:0000313|EMBL:EFI02995.1}.
FT   DOMAIN          5..211
FT                   /note="Acetyl-CoA hydrolase/transferase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF02550"
FT   DOMAIN          317..458
FT                   /note="Acetyl-CoA hydrolase/transferase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF13336"
FT   ACT_SITE        284
FT                   /note="5-glutamyl coenzyme A thioester intermediate"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR617821-1"
FT   BINDING         354
FT                   /ligand="CoA"
FT                   /ligand_id="ChEBI:CHEBI:57287"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR617821-2"
FT   BINDING         374
FT                   /ligand="CoA"
FT                   /ligand_id="ChEBI:CHEBI:57287"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR617821-2"
FT   BINDING         378
FT                   /ligand="CoA"
FT                   /ligand_id="ChEBI:CHEBI:57287"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR617821-2"
FT   BINDING         398
FT                   /ligand="CoA"
FT                   /ligand_id="ChEBI:CHEBI:57287"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR617821-2"
SQ   SEQUENCE   499 AA;  53950 MW;  248FCDE7AE6B4917 CRC64;
     MSFNRISAAE AASLIKHGYN IGLSGFTPAG TAKAVTAELA KIAEAEHAKG NPFQVGIFTG
     ASTGESCDGV MSRAKAIRYR APYTTNSDFR KAVNNGEIAY NDIHLSQMAQ EVRYGFMGKV
     NVAIIEACEV TPDGKIYLTA AGGISPTICR LADQIIVELN AAHSKSCMGL HDVYEPLDPP
     YRREIPIYKP SDRIGLPYIQ VDPKKIVGVV ETNWPDEARS FAAADPLTDK IGQNVADFLA
     ADMKRGIIPS TFLPLQSGVG NIANAVLGAL GRDKTIPAFE MYTEVIQNSV IGLIREGRIK
     FGSACSLTVT NDCLEGIYND MDFFRDKLVL RPSEISNNPE VVRRLGIISI NTAIEVDLYG
     NVNSTHIGGT KMMNGIGGSG DFTRNAYISI FTCPSVAKEG KISAIVPMVS HLDHSEHSVN
     IIITEQGVAD LRGKSPKERA QAIIENCAHP DYKQLLWDYL KLAGGKAQTP HAIQAALGMH
     AELAKSGDMK NTNWAEYAR
//