ID   D7KCD2_ARALL            Unreviewed;       513 AA.
AC   D7KCD2;
DT   10-AUG-2010, integrated into UniProtKB/TrEMBL.
DT   10-AUG-2010, sequence version 1.
DT   27-MAR-2024, entry version 51.
DE   RecName: Full=CNNM transmembrane domain-containing protein {ECO:0000259|PROSITE:PS51846};
GN   ORFNames=ARALYDRAFT_311427 {ECO:0000313|EMBL:EFH65706.1};
OS   Arabidopsis lyrata subsp. lyrata (Lyre-leaved rock-cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=81972 {ECO:0000313|Proteomes:UP000008694};
RN   [1] {ECO:0000313|Proteomes:UP000008694}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. MN47 {ECO:0000313|Proteomes:UP000008694};
RX   PubMed=21478890; DOI=10.1038/ng.807;
RA   Hu T.T., Pattyn P., Bakker E.G., Cao J., Cheng J.-F., Clark R.M.,
RA   Fahlgren N., Fawcett J.A., Grimwood J., Gundlach H., Haberer G.,
RA   Hollister J.D., Ossowski S., Ottilar R.P., Salamov A.A., Schneeberger K.,
RA   Spannagl M., Wang X., Yang L., Nasrallah M.E., Bergelson J.,
RA   Carrington J.C., Gaut B.S., Schmutz J., Mayer K.F.X., Van de Peer Y.,
RA   Grigoriev I.V., Nordborg M., Weigel D., Guo Y.-L.;
RT   "The Arabidopsis lyrata genome sequence and the basis of rapid genome size
RT   change.";
RL   Nat. Genet. 43:476-481(2011).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR   EMBL; GL348713; EFH65706.1; -; Genomic_DNA.
DR   RefSeq; XP_002889447.1; XM_002889401.1.
DR   AlphaFoldDB; D7KCD2; -.
DR   STRING; 81972.D7KCD2; -.
DR   EnsemblPlants; fgenesh1_pm.C_scaffold_1000207; fgenesh1_pm.C_scaffold_1000207; fgenesh1_pm.C_scaffold_1000207.
DR   Gramene; fgenesh1_pm.C_scaffold_1000207; fgenesh1_pm.C_scaffold_1000207; fgenesh1_pm.C_scaffold_1000207.
DR   eggNOG; KOG2118; Eukaryota.
DR   HOGENOM; CLU_011310_0_0_1; -.
DR   Proteomes; UP000008694; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0010960; P:magnesium ion homeostasis; IEA:InterPro.
DR   CDD; cd04590; CBS_pair_CorC_HlyC_assoc; 1.
DR   Gene3D; 3.10.580.10; CBS-domain; 2.
DR   InterPro; IPR045095; ACDP.
DR   InterPro; IPR046342; CBS_dom_sf.
DR   InterPro; IPR002550; CNNM.
DR   InterPro; IPR044751; Ion_transp-like_CBS.
DR   PANTHER; PTHR12064:SF101; CNNM TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN; 1.
DR   PANTHER; PTHR12064; METAL TRANSPORTER CNNM; 1.
DR   Pfam; PF01595; CNNM; 1.
DR   SUPFAM; SSF54631; CBS-domain pair; 1.
DR   PROSITE; PS51846; CNNM; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PROSITE-
KW   ProRule:PRU01193}; Reference proteome {ECO:0000313|Proteomes:UP000008694};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|PROSITE-
KW   ProRule:PRU01193};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, ECO:0000256|PROSITE-
KW   ProRule:PRU01193}.
FT   TRANSMEM        31..63
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        116..137
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        144..167
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          29..225
FT                   /note="CNNM transmembrane"
FT                   /evidence="ECO:0000259|PROSITE:PS51846"
SQ   SEQUENCE   513 AA;  56441 MW;  C1B593AF3D72BA7E CRC64;
     MVVLSTLALV RAAYSLNSFV FEAEDIRFGS PWWFVVVGVA CFLVLFAGIM SGLTLGLMSL
     GLVELEILQQ SGSSAEKKQA AAILPVVKKQ HQLLVTLLLC NAAAMEALPI CLDKIFHPFV
     AVLLSVTFVL AFGEIIPQAI CSRYGLAVGA NFLWLVRILM ILCYPIAYPI GKVMLCLLLS
     TFYMPQVLDA VIGHNDTLFR RAQLKALVSI HSQEAGKGGE LTHEETMIIS GALDLSQKTA
     EEAMTPIEST FSLDVNTKLD WETIGKILSR GHSRIPVYLG NPKNIIGLLL VKSLLTVRAE
     TEAPVSSVSI RKIPRVPSDM PLYDILNEFQ KGSSHMAAVV KVKDRDKMNN MQLLINGETP
     KENMKFYESS NLTAPLLKHE SHDVVVDIDK VPKHVKNRGR NFQQHGTVTR DLPRLLEDNE
     DAEVIGIITL EDVFEELLQA EIVDETDVYI DVHKRVRVAA AAAAAVSSIT RASPAEIQSK
     VGQTVKKLVG KEARGTKNYT TKITETLLAE SDR
//