ID D7L0N4_ARALL Unreviewed; 660 AA.
AC D7L0N4;
DT 10-AUG-2010, integrated into UniProtKB/TrEMBL.
DT 10-AUG-2010, sequence version 1.
DT 27-MAR-2024, entry version 66.
DE SubName: Full=CBS domain-containing protein {ECO:0000313|EMBL:EFH61199.1};
GN ORFNames=ARALYDRAFT_478681 {ECO:0000313|EMBL:EFH61199.1};
OS Arabidopsis lyrata subsp. lyrata (Lyre-leaved rock-cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=81972 {ECO:0000313|Proteomes:UP000008694};
RN [1] {ECO:0000313|Proteomes:UP000008694}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. MN47 {ECO:0000313|Proteomes:UP000008694};
RX PubMed=21478890; DOI=10.1038/ng.807;
RA Hu T.T., Pattyn P., Bakker E.G., Cao J., Cheng J.-F., Clark R.M.,
RA Fahlgren N., Fawcett J.A., Grimwood J., Gundlach H., Haberer G.,
RA Hollister J.D., Ossowski S., Ottilar R.P., Salamov A.A., Schneeberger K.,
RA Spannagl M., Wang X., Yang L., Nasrallah M.E., Bergelson J.,
RA Carrington J.C., Gaut B.S., Schmutz J., Mayer K.F.X., Van de Peer Y.,
RA Grigoriev I.V., Nordborg M., Weigel D., Guo Y.-L.;
RT "The Arabidopsis lyrata genome sequence and the basis of rapid genome size
RT change.";
RL Nat. Genet. 43:476-481(2011).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; GL348715; EFH61199.1; -; Genomic_DNA.
DR RefSeq; XP_002884940.1; XM_002884894.1.
DR AlphaFoldDB; D7L0N4; -.
DR STRING; 81972.D7L0N4; -.
DR EnsemblPlants; fgenesh2_kg.3__1382__AT3G13070.1; fgenesh2_kg.3__1382__AT3G13070.1; fgenesh2_kg.3__1382__AT3G13070.1.
DR GeneID; 9318872; -.
DR Gramene; fgenesh2_kg.3__1382__AT3G13070.1; fgenesh2_kg.3__1382__AT3G13070.1; fgenesh2_kg.3__1382__AT3G13070.1.
DR KEGG; aly:9318872; -.
DR eggNOG; KOG2118; Eukaryota.
DR HOGENOM; CLU_015237_4_4_1; -.
DR OrthoDB; 1256at2759; -.
DR Proteomes; UP000008694; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.
DR CDD; cd04590; CBS_pair_CorC_HlyC_assoc; 1.
DR Gene3D; 3.30.465.10; -; 1.
DR Gene3D; 3.10.580.10; CBS-domain; 1.
DR InterPro; IPR000644; CBS_dom.
DR InterPro; IPR046342; CBS_dom_sf.
DR InterPro; IPR002550; CNNM.
DR InterPro; IPR036318; FAD-bd_PCMH-like_sf.
DR InterPro; IPR016169; FAD-bd_PCMH_sub2.
DR InterPro; IPR044751; Ion_transp-like_CBS.
DR InterPro; IPR005170; Transptr-assoc_dom.
DR PANTHER; PTHR22777; HEMOLYSIN-RELATED; 1.
DR PANTHER; PTHR22777:SF17; UPF0053 INNER MEMBRANE PROTEIN YFJD; 1.
DR Pfam; PF00571; CBS; 2.
DR Pfam; PF01595; CNNM; 1.
DR Pfam; PF03471; CorC_HlyC; 1.
DR SMART; SM00116; CBS; 2.
DR SMART; SM01091; CorC_HlyC; 1.
DR SUPFAM; SSF54631; CBS-domain pair; 1.
DR SUPFAM; SSF56176; FAD-binding/transporter-associated domain-like; 1.
DR PROSITE; PS51371; CBS; 2.
DR PROSITE; PS51846; CNNM; 1.
PE 4: Predicted;
KW CBS domain {ECO:0000256|ARBA:ARBA00023122, ECO:0000256|PROSITE-
KW ProRule:PRU00703};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PROSITE-
KW ProRule:PRU01193}; Reference proteome {ECO:0000313|Proteomes:UP000008694};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|PROSITE-
KW ProRule:PRU01193};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, ECO:0000256|PROSITE-
KW ProRule:PRU01193}.
FT TRANSMEM 163..186
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 213..232
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 238..262
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 283..305
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 154..340
FT /note="CNNM transmembrane"
FT /evidence="ECO:0000259|PROSITE:PS51846"
FT DOMAIN 359..420
FT /note="CBS"
FT /evidence="ECO:0000259|PROSITE:PS51371"
FT DOMAIN 426..484
FT /note="CBS"
FT /evidence="ECO:0000259|PROSITE:PS51371"
FT REGION 559..579
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 627..660
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 643..660
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 660 AA; 73658 MW; 78958C704F14635B CRC64;
MTGMALELSV LGRSVIDSKT LNLKRYGQKS KLSGRFLPRA ELHCPVALSS SKSSNLSFRF
RRSCEFSYRS RFMLFSSSQC HEGSQQNSES GEKELESIKV LLKRGIVLGA VVCGVFLYGC
QKVLASAGVM EAGYEVFGQS VVLFKNALPK IYQVLRVLRE QGLILAALLS LSAFFSMAET
SITTLWPWKV RELAEKEPEN GVFRMLRSDV TRFLTTILIG TTVVNIAATA LVTEAATAIF
GEAGVSAATG LMTVAILLLT EITPKSVAVH NAQEVARIVV RPVAWLSLIL YPVGRIVTYL
SMGILKILGL KGRSEPYVTE DELKLMLRGA ELSGAIEEEE QDMIENVLEI KDTHVREVMT
PLVDVVAIDA SASLVEFHSM WVTHQYSRVP VFEQRIDNIV GIAYAMDLLD YVQKGDLLES
TSVGDMAHKP AYFVPDSMSV WNLLREFRIR KVHMAVVLNE YGGTIGIVTL EDVVEEIVGE
IFDENDSKEE IQKKTGYIVM RDEGIYDVDA NTSIDQLSEE LNMKMPEGIQ YETVSGFVCE
AFGYIPKTGE SVKVVLEKES WEEDGDEEEG KQERQEPKEK NQIYRVEILA GNARKVSAVR
FERVNDMDQV SEARDVKSMV PKFVRKWSSE EDDGNLSNDD QSEDAVLDEH VLADNSKKQQ
//
