ID D7LGP6_ARALL Unreviewed; 448 AA.
AC D7LGP6;
DT 10-AUG-2010, integrated into UniProtKB/TrEMBL.
DT 10-AUG-2010, sequence version 1.
DT 27-MAR-2024, entry version 56.
DE SubName: Full=Photolyase/blue-light receptor 2 {ECO:0000313|EMBL:EFH56573.1};
GN Name=PHR2 {ECO:0000313|EMBL:EFH56573.1};
GN ORFNames=ARALYDRAFT_483939 {ECO:0000313|EMBL:EFH56573.1};
OS Arabidopsis lyrata subsp. lyrata (Lyre-leaved rock-cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=81972 {ECO:0000313|Proteomes:UP000008694};
RN [1] {ECO:0000313|Proteomes:UP000008694}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. MN47 {ECO:0000313|Proteomes:UP000008694};
RX PubMed=21478890; DOI=10.1038/ng.807;
RA Hu T.T., Pattyn P., Bakker E.G., Cao J., Cheng J.-F., Clark R.M.,
RA Fahlgren N., Fawcett J.A., Grimwood J., Gundlach H., Haberer G.,
RA Hollister J.D., Ossowski S., Ottilar R.P., Salamov A.A., Schneeberger K.,
RA Spannagl M., Wang X., Yang L., Nasrallah M.E., Bergelson J.,
RA Carrington J.C., Gaut B.S., Schmutz J., Mayer K.F.X., Van de Peer Y.,
RA Grigoriev I.V., Nordborg M., Weigel D., Guo Y.-L.;
RT "The Arabidopsis lyrata genome sequence and the basis of rapid genome size
RT change.";
RL Nat. Genet. 43:476-481(2011).
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|PIRSR:PIRSR602081-1};
CC Note=Binds 1 FAD per subunit. {ECO:0000256|PIRSR:PIRSR602081-1};
CC -!- SIMILARITY: Belongs to the DNA photolyase class-1 family.
CC {ECO:0000256|ARBA:ARBA00005862}.
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DR EMBL; GL348716; EFH56573.1; -; Genomic_DNA.
DR RefSeq; XP_002880314.1; XM_002880268.1.
DR AlphaFoldDB; D7LGP6; -.
DR STRING; 81972.D7LGP6; -.
DR EnsemblPlants; fgenesh2_kg.4__2999__AT2G47590.1; fgenesh2_kg.4__2999__AT2G47590.1; fgenesh2_kg.4__2999__AT2G47590.1.
DR Gramene; fgenesh2_kg.4__2999__AT2G47590.1; fgenesh2_kg.4__2999__AT2G47590.1; fgenesh2_kg.4__2999__AT2G47590.1.
DR eggNOG; KOG0133; Eukaryota.
DR HOGENOM; CLU_010348_0_0_1; -.
DR OrthoDB; 124765at2759; -.
DR Proteomes; UP000008694; Unassembled WGS sequence.
DR GO; GO:0016829; F:lyase activity; IEA:UniProtKB-KW.
DR GO; GO:0051716; P:cellular response to stimulus; IEA:UniProt.
DR GO; GO:0006139; P:nucleobase-containing compound metabolic process; IEA:UniProt.
DR GO; GO:0006950; P:response to stress; IEA:UniProt.
DR Gene3D; 1.25.40.80; -; 1.
DR Gene3D; 3.40.50.620; HUPs; 1.
DR InterPro; IPR036134; Crypto/Photolyase_FAD-like_sf.
DR InterPro; IPR036155; Crypto/Photolyase_N_sf.
DR InterPro; IPR002081; Cryptochrome/DNA_photolyase_1.
DR InterPro; IPR006050; DNA_photolyase_N.
DR InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR PANTHER; PTHR11455:SF2; BLUE-LIGHT PHOTORECEPTOR PHR2; 1.
DR PANTHER; PTHR11455; CRYPTOCHROME; 1.
DR Pfam; PF00875; DNA_photolyase; 1.
DR SUPFAM; SSF48173; Cryptochrome/photolyase FAD-binding domain; 1.
DR SUPFAM; SSF52425; Cryptochrome/photolyase, N-terminal domain; 1.
DR PROSITE; PS51645; PHR_CRY_ALPHA_BETA; 1.
PE 3: Inferred from homology;
KW FAD {ECO:0000256|PIRSR:PIRSR602081-1};
KW Flavoprotein {ECO:0000256|PIRSR:PIRSR602081-1};
KW Lyase {ECO:0000313|EMBL:EFH56573.1};
KW Receptor {ECO:0000313|EMBL:EFH56573.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000008694}.
FT DOMAIN 116..250
FT /note="Photolyase/cryptochrome alpha/beta"
FT /evidence="ECO:0000259|PROSITE:PS51645"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..15
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 365..369
FT /ligand="FAD"
FT /ligand_id="ChEBI:CHEBI:57692"
FT /evidence="ECO:0000256|PIRSR:PIRSR602081-1"
FT BINDING 414..421
FT /ligand="FAD"
FT /ligand_id="ChEBI:CHEBI:57692"
FT /evidence="ECO:0000256|PIRSR:PIRSR602081-1"
SQ SEQUENCE 448 AA; 49014 MW; E5710086B322C831 CRC64;
MDSNLEEKNL NPETKSAEEE NPLAIIHSSL PIASLSLTLF PTSTQFLKLF SHHPNKVKIP
TQASSLTHLS LSSSPVSPLP SRISFKSTIA ANPLHSPLSI VPRRPVDPSS AAALRRAAVV
WFRNDLRVHD NECLNSANDE CVSVLPVYCF DPRDYGKSSS GFDKTGPFRA QFLIESVSEL
RKNLQARGSN LVVRVGKPEA VLVELAKEIG ADAVYAHREV SHDEVKAEGK IESAMKEEGV
EVKYFWGSTL YHLDDLPFKI EDLPSNYGAF KDKVHKLEIR KTIAALDQLK SLPSRGDVEL
GDIPSLLDLG ISPTARTSQE GKPTMVGGET EALTRLKSFA ADCQARLSKG NQKGGNNSVF
GANFSCKISP WLAMGSISPR SMFDELKKTI SASTTTTTPR NGPGDTGLNW LMYELLWRDF
FRFITKKYSS AKTQVEAGPA TACTGAFV
//
