ID D7LR49_ARALL Unreviewed; 477 AA.
AC D7LR49;
DT 10-AUG-2010, integrated into UniProtKB/TrEMBL.
DT 10-AUG-2010, sequence version 1.
DT 27-MAR-2024, entry version 55.
DE SubName: Full=Methyltransferase/ nucleic acid binding protein {ECO:0000313|EMBL:EFH53229.1};
GN ORFNames=ARALYDRAFT_484403 {ECO:0000313|EMBL:EFH53229.1};
OS Arabidopsis lyrata subsp. lyrata (Lyre-leaved rock-cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=81972 {ECO:0000313|Proteomes:UP000008694};
RN [1] {ECO:0000313|Proteomes:UP000008694}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. MN47 {ECO:0000313|Proteomes:UP000008694};
RX PubMed=21478890; DOI=10.1038/ng.807;
RA Hu T.T., Pattyn P., Bakker E.G., Cao J., Cheng J.-F., Clark R.M.,
RA Fahlgren N., Fawcett J.A., Grimwood J., Gundlach H., Haberer G.,
RA Hollister J.D., Ossowski S., Ottilar R.P., Salamov A.A., Schneeberger K.,
RA Spannagl M., Wang X., Yang L., Nasrallah M.E., Bergelson J.,
RA Carrington J.C., Gaut B.S., Schmutz J., Mayer K.F.X., Van de Peer Y.,
RA Grigoriev I.V., Nordborg M., Weigel D., Guo Y.-L.;
RT "The Arabidopsis lyrata genome sequence and the basis of rapid genome size
RT change.";
RL Nat. Genet. 43:476-481(2011).
CC -!- FUNCTION: Catalytic subunit of an S-adenosyl-L-methionine-dependent
CC tRNA methyltransferase complex that mediates the methylation of the
CC guanosine nucleotide at position 10 (m2G10) in tRNAs.
CC {ECO:0000256|ARBA:ARBA00002425}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; GL348717; EFH53229.1; -; Genomic_DNA.
DR RefSeq; XP_002876970.1; XM_002876924.1.
DR AlphaFoldDB; D7LR49; -.
DR STRING; 81972.D7LR49; -.
DR EnsemblPlants; fgenesh2_kg.5__395__AT3G26410.1; fgenesh2_kg.5__395__AT3G26410.1; fgenesh2_kg.5__395__AT3G26410.1.
DR GeneID; 9311386; -.
DR Gramene; fgenesh2_kg.5__395__AT3G26410.1; fgenesh2_kg.5__395__AT3G26410.1; fgenesh2_kg.5__395__AT3G26410.1.
DR KEGG; aly:9311386; -.
DR eggNOG; KOG2671; Eukaryota.
DR HOGENOM; CLU_029646_4_0_1; -.
DR OrthoDB; 5488599at2759; -.
DR Proteomes; UP000008694; Unassembled WGS sequence.
DR GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0080180; P:2-methylguanosine metabolic process; IEA:EnsemblPlants.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR GO; GO:0006400; P:tRNA modification; IEA:EnsemblPlants.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR002052; DNA_methylase_N6_adenine_CS.
DR InterPro; IPR000241; RlmKL-like_Mtase.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR016691; tRNA_mtfrase_TRM11.
DR PANTHER; PTHR13370; RNA METHYLASE-RELATED; 1.
DR PANTHER; PTHR13370:SF3; TRNA (GUANINE(10)-N2)-METHYLTRANSFERASE HOMOLOG; 1.
DR Pfam; PF01170; UPF0020; 1.
DR PIRSF; PIRSF017259; tRNA_mtfrase_TRM11; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS00092; N6_MTASE; 1.
DR PROSITE; PS51627; SAM_MT_TRM11; 1.
PE 4: Predicted;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000313|EMBL:EFH53229.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000008694};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022555};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:EFH53229.1};
KW tRNA-binding {ECO:0000256|ARBA:ARBA00022555}.
FT DOMAIN 193..314
FT /note="UPF0020"
FT /evidence="ECO:0000259|Pfam:PF01170"
SQ SEQUENCE 477 AA; 54661 MW; 3D52630D8B79E1C0 CRC64;
MWFLCVFYHR LLDFRKPEVE ALAELFGEEI AENESLQWRL PEHHHNDTPF HFVQLSSEEI
ARNIAKRSIL VKGMYELWGE GTCYEELKDS IQSYPDSRKL PFLTSDSTFR ISVETFGKAL
TFEEQKDRIQ SLTYIPFEGR VDLKNPDHNF FLMEMIESEE NNGLQPILQR RIFFGREVGF
ADRKLLPTFQ LKSRTYLGPT AMDAEMAFLM ANQAKATSGK LVYDPFVGTG SILVSAARFG
AMTMGADIDI RVVRDGRGPD CNVWSNFKQY GLPTPVALLR MDNNVPPWRS GLKEIFDAII
CDPPYGVRAG GRKSGGRKIL RGTVDPYTVP DDKRTDHIPS TGAYSLVECV HDLLHLAARM
LVMKGRLVFF FPVLRDETGS EVKFPEHPCF KLVAVSEQIL SSRYSRVLLT MVKVEPYSED
IEEAARLMHL EFRENHLKWL EDGNIHSSVF KPIDSSQIHT DPKTFKDPKP KYRGKYV
//
