ID D7MRD3_ARALL Unreviewed; 1113 AA.
AC D7MRD3;
DT 10-AUG-2010, integrated into UniProtKB/TrEMBL.
DT 10-AUG-2010, sequence version 1.
DT 27-MAR-2024, entry version 53.
DE RecName: Full=ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase {ECO:0000256|ARBA:ARBA00011982};
DE EC=3.2.2.6 {ECO:0000256|ARBA:ARBA00011982};
GN ORFNames=ARALYDRAFT_683347 {ECO:0000313|EMBL:EFH41438.1};
OS Arabidopsis lyrata subsp. lyrata (Lyre-leaved rock-cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=81972 {ECO:0000313|Proteomes:UP000008694};
RN [1] {ECO:0000313|Proteomes:UP000008694}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. MN47 {ECO:0000313|Proteomes:UP000008694};
RX PubMed=21478890; DOI=10.1038/ng.807;
RA Hu T.T., Pattyn P., Bakker E.G., Cao J., Cheng J.-F., Clark R.M.,
RA Fahlgren N., Fawcett J.A., Grimwood J., Gundlach H., Haberer G.,
RA Hollister J.D., Ossowski S., Ottilar R.P., Salamov A.A., Schneeberger K.,
RA Spannagl M., Wang X., Yang L., Nasrallah M.E., Bergelson J.,
RA Carrington J.C., Gaut B.S., Schmutz J., Mayer K.F.X., Van de Peer Y.,
RA Grigoriev I.V., Nordborg M., Weigel D., Guo Y.-L.;
RT "The Arabidopsis lyrata genome sequence and the basis of rapid genome size
RT change.";
RL Nat. Genet. 43:476-481(2011).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + NAD(+) = ADP-D-ribose + H(+) + nicotinamide;
CC Xref=Rhea:RHEA:16301, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:17154, ChEBI:CHEBI:57540, ChEBI:CHEBI:57967; EC=3.2.2.6;
CC Evidence={ECO:0000256|ARBA:ARBA00000404};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:16302;
CC Evidence={ECO:0000256|ARBA:ARBA00000404};
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DR EMBL; GL348720; EFH41438.1; -; Genomic_DNA.
DR RefSeq; XP_002865179.1; XM_002865133.1.
DR AlphaFoldDB; D7MRD3; -.
DR STRING; 81972.D7MRD3; -.
DR EnsemblPlants; Al_scaffold_0008_167; Al_scaffold_0008_167; Al_scaffold_0008_167.
DR Gramene; Al_scaffold_0008_167; Al_scaffold_0008_167; Al_scaffold_0008_167.
DR eggNOG; ENOG502QQ7T; Eukaryota.
DR HOGENOM; CLU_001561_0_1_1; -.
DR Proteomes; UP000008694; Unassembled WGS sequence.
DR GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR GO; GO:0006952; P:defense response; IEA:InterPro.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR Gene3D; 1.10.8.430; Helical domain of apoptotic protease-activating factors; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 3.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR InterPro; IPR042197; Apaf_helical.
DR InterPro; IPR045344; C-JID.
DR InterPro; IPR044974; Disease_R_plants.
DR InterPro; IPR011713; Leu-rich_rpt_3.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR002182; NB-ARC.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR11017:SF364; ADP-RIBOSYL CYCLASE_CYCLIC ADP-RIBOSE HYDROLASE-RELATED; 1.
DR PANTHER; PTHR11017; LEUCINE-RICH REPEAT-CONTAINING PROTEIN; 1.
DR Pfam; PF20160; C-JID; 1.
DR Pfam; PF07725; LRR_3; 1.
DR Pfam; PF00931; NB-ARC; 1.
DR Pfam; PF01582; TIR; 1.
DR PRINTS; PR00364; DISEASERSIST.
DR SMART; SM00255; TIR; 1.
DR SUPFAM; SSF52058; L domain-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS50104; TIR; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000008694}.
FT DOMAIN 5..169
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
SQ SEQUENCE 1113 AA; 126564 MW; 1925C5EE1A8BBD07 CRC64;
MSRIWQYDVF ISFRGDDLRH NFLAHFRKEL DRKLIRTFND MEIEKGESLD PVLTQAIRGS
KIAVVLFSKN YASSGWCLNE LLEIVKCKKE IGQLVIPIFH GVDPSHVRHQ IGDFGSIFEK
TCRRHSEEVK NQWKKALTEV ANMVGTHLQN WDNEAKQIEY IVNDLLGTVI LTPSKDFEDT
VGIEDHIAKI SLILDLKFES KEVRRVGIWG PSGIGKTTIA RALYSQHSHV FDVCVFLDIH
FVSKSTKNYR KGNPDDYNMK LCLQKSFLSK ILDQKDIEVE HLGVIEERLK HQKVLIVLDD
LDDQMVLDTL VGKDEWFGCG SRIIVITKDK RLLEAHGINH IYEVGFPSEK QALEMFCHSA
FGQKSPDDGF VELATEVAAR AGGLPLGLKI LGKVMKNRKV EEWKGELLSL QKNQNGDIGK
TLKVSYDKID IQKHRAIFRH IACFFNGAEI DNIKLMLPEL DVETGVRHLV EKSLISSKSS
WNNTCTVDMH CLVQEMGKQL VRAQSEEPGE REFLFDSDDV CNVLGGTNGT NKVIGISLDL
NEIDELEIHK KAFKNMHNLR FLRFHINSWE REKEVEWNLP KKIDAFPPKL KLLNWPGYPM
KQLPAEFRPD KLVELRMPNS KILEKLWEGD KSLKFLKDMD LSGSLNLKEI PDLSKATNLE
TLNLNGCSSL VELPSSILNL NKLTDLNMAG CTNLEALPTG KLESLIHLNL AGCSRLKIFP
DISNKISELI INKTAFEIFP SQLRLENLVE LSLEHTMSER LWEGVQPLTN LKTIKLLGSE
NLKELPNLSM ATSLETLNLN NCSSLVELTL STIQNLNKLT SLDMIGCSSL ETLPIGINLK
SLYRLNLNGC SQLRGFPDIS NNITFLFLNQ TAIEEVPSHI NNFSSLEALE MMGCKELKWI
SPGLFELKDL DEVFFSDCKK LGEVKWSEKA EDTKLSVISF TNCFYINQEI FIHQSASNYM
ILPGEVPPYF THRSTGNSLT IPLHHSSLSQ QPFLDFKACV VVSDLVVGSE AVVKKLCFMD
IEVHCHFIDK HGNYFEPAER KDLSVHQKYN HQIIFDCRFP LNLDCDQVQI KFLLPNERLK
LKRCGVRLSD DSTPFSAIQN QGYETALDED ECT
//
