ID   D7PCC8_WHEAT            Unreviewed;      1414 AA.
AC   D7PCC8;
DT   10-AUG-2010, integrated into UniProtKB/TrEMBL.
DT   10-AUG-2010, sequence version 1.
DT   27-MAR-2024, entry version 44.
DE   SubName: Full=Pm3 {ECO:0000313|EMBL:ADH04483.1};
GN   Name=Pm3 {ECO:0000313|EMBL:ADH04483.1};
OS   Triticum aestivum (Wheat).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC   Pooideae; Triticodae; Triticeae; Triticinae; Triticum.
OX   NCBI_TaxID=4565 {ECO:0000313|EMBL:ADH04483.1};
RN   [1] {ECO:0000313|EMBL:ADH04483.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=20470444; DOI=10.1186/1471-2229-10-88;
RA   Bhullar N.K., Zhang Z., Wicker T., Keller B.;
RT   "Wheat gene bank accessions as a source of new alleles of the powdery
RT   mildew resistance gene Pm3: a large scale allele mining project.";
RL   BMC Plant Biol. 10:88-88(2010).
CC   -!- SIMILARITY: Belongs to the disease resistance NB-LRR family.
CC       {ECO:0000256|ARBA:ARBA00008894}.
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DR   EMBL; GU230854; ADH04483.1; -; Genomic_DNA.
DR   ExpressionAtlas; D7PCC8; baseline and differential.
DR   GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR   GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR   GO; GO:0051707; P:response to other organism; IEA:UniProt.
DR   Gene3D; 1.20.5.4130; -; 1.
DR   Gene3D; 1.10.8.430; Helical domain of apoptotic protease-activating factors; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 4.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   InterPro; IPR042197; Apaf_helical.
DR   InterPro; IPR044974; Disease_R_plants.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   InterPro; IPR002182; NB-ARC.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR041118; Rx_N.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   PANTHER; PTHR23155; DISEASE RESISTANCE PROTEIN RP; 1.
DR   PANTHER; PTHR23155:SF1188; OS01G0359800 PROTEIN; 1.
DR   Pfam; PF00931; NB-ARC; 1.
DR   Pfam; PF18052; Rx_N; 1.
DR   PRINTS; PR00364; DISEASERSIST.
DR   SUPFAM; SSF52058; L domain-like; 2.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW   Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW   Plant defense {ECO:0000256|ARBA:ARBA00022821}.
FT   DOMAIN          14..99
FT                   /note="Disease resistance N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF18052"
FT   DOMAIN          182..398
FT                   /note="NB-ARC"
FT                   /evidence="ECO:0000259|Pfam:PF00931"
SQ   SEQUENCE   1414 AA;  158903 MW;  2368E5A13D60A26F CRC64;
     MAERVVTMAI GPLVSMLKDK ASSYLLDQYK VMEGMEEQHK ILKRKLPAIL DVITDVEEQA
     MAQREGAKAW LQELRTVAYV ANEVFDEFKY EALRREAKKN GHYIKLGFDV IKLFPTHNRV
     AFRYKMGRKL CLILQAVEVL IAEMQVFGFK YQPQPPVSKE WRHTDYVSID PQEIASRSRH
     EDKKNIIGIL VDEASNADLT VVPVVAMGGL GKTTLAQLIY NDPEIQKHFQ LLLWVCVSDT
     FDVNSLAKSI VEASPNKNVD TDKPPLDRLQ KLVSGQRYLL VLDDVWDNKE LRKWERLKVC
     LQHGGMGSAV LTTTRDKRVS EIMGADRAAY NLNALEDHFI KEIIEARAFS SKKEKPIELV
     EVVDEIVKRC CGSPLAATAL GSVLCTKTSV KEWKAVSSGT SVCTDETGIL PILKLSYNDL
     PAHMKQCFAF CAVFPKDYKI NVEKLIQLWI ANGFIPEHKE DSPETFGKHI FDELVSRSFF
     LDLEESKDYS GYYSSTCKIH DLMHDIAMSV MGKECVVAIK EPSQIEWLSD TARHLFLSCK
     GTEGILNASL EKRSPAIQTL ICDSPMQSSL KHLSKYNSLH ALKLCIRGTE SFLLKPMYLH
     HLRYLDLSES SIKALPEDIS ILYNLQVLDL SYCNYLDRLP RQMKYMTSLC HLYTHGCRNL
     KSMPPGLENL TKLQTLTVFV AGVPGPDCAD VGELHGLNIG GRLELCQVEN VEKAEAEVAN
     LGGQLELQHL NLGDQLELRR VENVKKAEAK VANLGNKKDL RELTLRWTEV GDSKVLDKFE
     PHGGLQVLKI YKYGGKCMGM LQNMVEIHLS GCERLQVLFS CGTSFTFPKL KVLTLEHLLD
     FERWWEINEA QEEQIIFPLL EKLFIRHCGK LIALPEAPLL GEPSRGGNRL VCTPFSLLEN
     LFIWYCGKLV PLREAPLVHE SCSGGYRLVQ SAFPALKVLA LEDLGSFQKW DAAVEGEPIL
     FPQLETLSVQ KCPKLVDLPE APKLSVLVIE DGKQEVFHFV DRYLSSLTNL TLRLEHRETT
     SEAECTSIVP VDSKEKWNQK SPLTVLELGC CNSFFGPGAL EPWDYFVHLE KLEIDRCDVL
     VHWPENVFQS LVSLRTLLIR NCKNLTGYAQ APLEPLASER SQHPRGLESL CLRNCPSLVE
     MFNVPASLKK MTIGGCIKLE SIFGKQQGMA ELVQVSSSSE AIMPATVSEL PSTPMNHFCP
     CLEDLCLSAC GSLPAVLNLP PSLKTLEMDR CSSIQVLSCQ LGGLQKPEAT TSRSRSPIMP
     QPLAAATAPA AREHLLPPHL EYLTILNCAG MLGGTLRLPA PLKRLFIMGN SGLTSLECLS
     GEHPPSLESL WLERCSTLAS LPNEPQVYRS LWSLEITGCP AIKKLPRCLQ QQLGSIKRKW
     LDARYEVTEF KPLKPKTWKE IPRLVRERRQ ACRS
//