ID D7PM75_9NEIS Unreviewed; 259 AA.
AC D7PM75;
DT 10-AUG-2010, integrated into UniProtKB/TrEMBL.
DT 10-AUG-2010, sequence version 1.
DT 24-JAN-2024, entry version 24.
DE RecName: Full=Aminoglycoside (3'') (9) adenylyltransferase {ECO:0000256|ARBA:ARBA00035252};
DE EC=2.7.7.47 {ECO:0000256|ARBA:ARBA00035126};
GN Name=aadA1 {ECO:0000313|EMBL:ADI46753.1};
OS Laribacter hongkongensis.
OC Bacteria; Pseudomonadota; Betaproteobacteria; Neisseriales;
OC Aquaspirillaceae; Laribacter.
OX NCBI_TaxID=168471 {ECO:0000313|EMBL:ADI46753.1};
RN [1] {ECO:0000313|EMBL:ADI46753.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=LHW350 {ECO:0000313|EMBL:ADI46753.1};
RA Feng J., Chen Q., Hu J.;
RL Submitted (FEB-2010) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ADI46753.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=LHW350 {ECO:0000313|EMBL:ADI46753.1};
RX PubMed=21075469; DOI=10.1016/j.ijfoodmicro.2010.10.014;
RA Feng J.L., Yan H., Chowdhury N., Neogi S.B., Yamasaki S., Shi L., Hu J.,
RA Chen Q.;
RT "Identification and characterization of integron-associated antibiotic
RT resistant Laribacter hongkongensis isolated from aquatic products in
RT China.";
RL Int. J. Food Microbiol. 144:337-341(2011).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + spectinomycin = 9-O-adenylylspectinomycin + diphosphate;
CC Xref=Rhea:RHEA:63228, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019,
CC ChEBI:CHEBI:146260, ChEBI:CHEBI:146261;
CC Evidence={ECO:0000256|ARBA:ARBA00001672};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + streptomycin = 3''-O-adenylylstreptomycin + diphosphate;
CC Xref=Rhea:RHEA:20245, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019,
CC ChEBI:CHEBI:58007, ChEBI:CHEBI:58605; EC=2.7.7.47;
CC Evidence={ECO:0000256|ARBA:ARBA00035070};
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DR EMBL; GU726914; ADI46753.1; -; Genomic_DNA.
DR AlphaFoldDB; D7PM75; -.
DR SMR; D7PM75; -.
DR GO; GO:0070566; F:adenylyltransferase activity; IEA:InterPro.
DR GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
DR CDD; cd05403; NT_KNTase_like; 1.
DR Gene3D; 3.30.460.10; Beta Polymerase, domain 2; 1.
DR InterPro; IPR024172; AadA/Aad9.
DR InterPro; IPR025184; AadA_C.
DR InterPro; IPR043519; NT_sf.
DR InterPro; IPR002934; Polymerase_NTP_transf_dom.
DR Pfam; PF13427; AadA_C; 1.
DR Pfam; PF01909; NTP_transf_2; 1.
DR PIRSF; PIRSF000819; Streptomycin_3-adenylyltransf; 1.
DR SUPFAM; SSF81301; Nucleotidyltransferase; 1.
PE 4: Predicted;
KW Antibiotic resistance {ECO:0000256|ARBA:ARBA00023251};
KW Transferase {ECO:0000313|EMBL:ADI46753.1}.
FT DOMAIN 24..93
FT /note="Polymerase nucleotidyl transferase"
FT /evidence="ECO:0000259|Pfam:PF01909"
FT DOMAIN 149..250
FT /note="Adenylyltransferase AadA C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13427"
SQ SEQUENCE 259 AA; 29123 MW; 259A643BC501E75D CRC64;
MTIEISNQLS EVLSVIERHL ESTLLAVHLY GSAVDGGLKP YSDIDLLVTV AVKLDETTRR
ALLNDLMEAS AFPGESETLR AIEVTLVVHD DIIPWRYPAK RELQFGEWQR NDILAGIFEP
AMIDIDLAIL LTKAREHSVA LVGPAAEEFF DPVPEQDLFE ALRETLKLWN SQPDWAGDER
NVVLTLSRIW YSAITGKIAP KDVAADWAIK RLPAQYQPVL LEAKQAYLGQ KEDHLASRAD
HLEEFIRFVK GEIIKSVGK
//
