ID D7R4L2_9CRUS Unreviewed; 1050 AA.
AC D7R4L2;
DT 10-AUG-2010, integrated into UniProtKB/TrEMBL.
DT 10-AUG-2010, sequence version 1.
DT 27-MAR-2024, entry version 57.
DE SubName: Full=Hypoxia-inducible factor 1 alpha {ECO:0000313|EMBL:ADH01740.1};
GN Name=HIF-1a {ECO:0000313|EMBL:ADH01740.1};
OS Oratosquilla oratoria.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Crustacea; Multicrustacea;
OC Malacostraca; Eumalacostraca; Hoplocarida; Stomatopoda; Squillidae;
OC Oratosquilla.
OX NCBI_TaxID=337810 {ECO:0000313|EMBL:ADH01740.1};
RN [1] {ECO:0000313|EMBL:ADH01740.1}
RP NUCLEOTIDE SEQUENCE.
RA Kodama K., Rahman M.S., Lee J.H., Horiguchi T., Thomas P.;
RL Submitted (MAR-2010) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; HM032914; ADH01740.1; -; mRNA.
DR AlphaFoldDB; D7R4L2; -.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:UniProt.
DR CDD; cd11433; bHLH-PAS_HIF; 1.
DR CDD; cd00130; PAS; 2.
DR Gene3D; 3.30.450.20; PAS domain; 2.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR014887; HIF-1_CTAD.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR InterPro; IPR000014; PAS.
DR InterPro; IPR035965; PAS-like_dom_sf.
DR InterPro; IPR013767; PAS_fold.
DR NCBIfam; TIGR00229; sensory_box; 1.
DR PANTHER; PTHR23043; HYPOXIA-INDUCIBLE FACTOR 1 ALPHA; 1.
DR PANTHER; PTHR23043:SF17; PROTEIN SIMILAR; 1.
DR Pfam; PF08778; HIF-1a_CTAD; 1.
DR Pfam; PF00989; PAS; 1.
DR Pfam; PF14598; PAS_11; 1.
DR SMART; SM00353; HLH; 1.
DR SMART; SM00091; PAS; 2.
DR SUPFAM; SSF47459; HLH, helix-loop-helix DNA-binding domain; 1.
DR SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 2.
DR PROSITE; PS50888; BHLH; 1.
DR PROSITE; PS50112; PAS; 2.
PE 2: Evidence at transcript level;
FT DOMAIN 27..80
FT /note="BHLH"
FT /evidence="ECO:0000259|PROSITE:PS50888"
FT DOMAIN 101..164
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT DOMAIN 244..295
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT REGION 1..38
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 364..391
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 836..865
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 13..38
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 364..379
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1050 AA; 113556 MW; 23DF2B0EAF999208 CRC64;
MCLQTQLPSL ERPAEQRRQK TPKNSEKRKE KSRDAARCRR GKETEIFTEL ASALPLPQKT
IAQLDKASVM RLTIAFLKTR ALCEKGVLRK VKEMGDGSKI DAEMDSSLLK ALDGFVVILS
MEGDIVYLSD NVSTHLGVSQ VEMMGQLLTD YTHPCDHEEA RELLSLKCST DHRFAFLRLK
CTLAAKGRNV NLKSATYKVV QVSGEIVHSD GGVDSWFVAL ASPVPNPANV EFPLDKQTFV
SRHSLDMKFT YVDDSICEFL GYGPEELVGQ SAYALHHALD AQIVKESFKT LLVKGQVETS
RYRFLARGGG YAWVVTQATR ITGPKDHKPQ CIVCLNYVVS GIETPELILS DLQLLYKKSD
AKGSSKNKIE DEKKPRLAVK SSSLPESSHC VPKTVRVNTG RSAPIPPPTP VAATVKIFAP
RTEDMNKGFL TFSKEDPEGT ILKEEPEDLT RLAPSGGEDC WPLNDPFFPE LNDVFDLGQI
DSGFEDTSSL LNASGQLDKN NAEGKLLVHK NLVDSLASKS AASLINKLIK TEDGQYVQIN
DLQKPVFEIR SEPQVKQDAP VGTIISGGGS IFLGGELKGG GTKDQRAIKA RCSDGTSFLN
VAKTPRLATQ KKESTSVPQP SRPVATTASL FTTLGEITSN KPTSVTESLF EPGEDLGIRK
PTGQTATFLS PLGDSQVTNS TMDVFTSSEY KTNEPDCEDL HRAPYIPPKD EVLLLRSEDL
MWGPQFEGLN SPPEIQASSP SGCEDLPLDE NSSSLARLLQ DRGTLESLPL ESDFKLGIGT
NSRQPKFIES GGSFVDPNKV LPGHYINKDA LGGSFLQIFN TNSSDPPTSI IQECEEPPPL
NKESGGVKRS HSPMVSPPAS PKKFCQNTEA RSTPLLTPYA PTMQQLLVSK DPIPVPKRGY
VGANSDAGDG GGGGGSGGGV GNHSVLLNLL NTRVVPISVT LGNGAPMARA LLSTAGCKTP
SPLASLNPTG GFPQGLKLVK PGHLNGPRVE AAKNERVLPR RQDPFLLLSP DQTIPNLLDL
TQLDYEVNAP TASTNLLQGS DLLTALDQSL
//
