ID D8ABQ6_ECOMS Unreviewed; 438 AA.
AC D8ABQ6;
DT 05-OCT-2010, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2010, sequence version 1.
DT 24-JAN-2024, entry version 45.
DE SubName: Full=Dual specificity phosphatase, catalytic domain protein {ECO:0000313|EMBL:EFK19433.1};
GN ORFNames=HMPREF9530_03993 {ECO:0000313|EMBL:EFK19433.1};
OS Escherichia coli (strain MS 21-1).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=749527 {ECO:0000313|EMBL:EFK19433.1, ECO:0000313|Proteomes:UP000005688};
RN [1] {ECO:0000313|EMBL:EFK19433.1, ECO:0000313|Proteomes:UP000005688}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MS 21-1 {ECO:0000313|EMBL:EFK19433.1,
RC ECO:0000313|Proteomes:UP000005688};
RA Weinstock G., Sodergren E., Clifton S., Fulton L., Fulton B., Courtney L.,
RA Fronick C., Harrison M., Strong C., Farmer C., Delahaunty K., Markovic C.,
RA Hall O., Minx P., Tomlinson C., Mitreva M., Hou S., Chen J., Wollam A.,
RA Pepin K.H., Johnson M., Bhonagiri V., Zhang X., Suruliraj S., Warren W.,
RA Chinwalla A., Mardis E.R., Wilson R.K.;
RL Submitted (JUN-2010) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EFK19433.1}.
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DR EMBL; ADTR01000365; EFK19433.1; -; Genomic_DNA.
DR AlphaFoldDB; D8ABQ6; -.
DR HOGENOM; CLU_031173_0_0_6; -.
DR Proteomes; UP000005688; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0008138; F:protein tyrosine/serine/threonine phosphatase activity; IEA:InterPro.
DR GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR CDD; cd14527; DSP_bac; 1.
DR CDD; cd03386; PAP2_Aur1_like; 1.
DR Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 1.
DR InterPro; IPR000340; Dual-sp_phosphatase_cat-dom.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR016130; Tyr_Pase_AS.
DR InterPro; IPR003595; Tyr_Pase_cat.
DR InterPro; IPR000387; Tyr_Pase_dom.
DR InterPro; IPR020422; TYR_PHOSPHATASE_DUAL_dom.
DR PANTHER; PTHR47216; -; 1.
DR PANTHER; PTHR47216:SF4; OS01G0859400 PROTEIN; 1.
DR Pfam; PF00782; DSPc; 1.
DR SMART; SM00195; DSPc; 1.
DR SMART; SM00404; PTPc_motif; 1.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 1.
DR PROSITE; PS00383; TYR_PHOSPHATASE_1; 1.
DR PROSITE; PS50056; TYR_PHOSPHATASE_2; 1.
DR PROSITE; PS50054; TYR_PHOSPHATASE_DUAL; 1.
PE 4: Predicted;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Protein phosphatase {ECO:0000256|ARBA:ARBA00022912};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..30
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 57..80
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 92..113
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 133..150
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 157..177
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 183..201
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 221..244
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 250..269
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 305..438
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50054"
FT DOMAIN 364..430
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
SQ SEQUENCE 438 AA; 50597 MW; A32293E53FFA73D2 CRC64;
MITERRNVLL QGAGWLLLLA PFFFFTYGFL NQFTATQHLN NHDIPSQVFG WETAIPFLPW
TIVPYWSLDL LYGFSLFVCS STFEQRRLVH RLILATVMAC CGFFLYPLKF SFIRPEVSGV
TGWLFSQLEL FDLPYNQSPS LHIILCWLLW RHFRQHLAVR LRKVCGGWFL LIAISTLTTW
QHHFIDVITG LAVGMLIDWM VPVDRRWNYQ KPDQRRIKIA LPYVVGACSC IVLMELMIML
QLWWSVWLCW PVLSLLIIGR GYGGLGAITT GKDSQGKLPP AVYWLTLPWR IGMWLSMRWF
CLRLEPVSKI TAGVYLGAFP QHIPAQNAVL DVTFEFPRGR ATKDQLYFCV PMLDLVVPEE
GELRQAVAML ETLREEQGGV LVHCALGLSR SALVVAAWLL CYGHCKTVDE AISYIRARRS
RIVLKEEHKA MLRLWENR
//
