ID D8F4L6_9DELT Unreviewed; 827 AA.
AC D8F4L6;
DT 05-OCT-2010, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2010, sequence version 1.
DT 27-MAR-2024, entry version 45.
DE RecName: Full=endopeptidase La {ECO:0000256|PROSITE-ProRule:PRU01122};
DE EC=3.4.21.53 {ECO:0000256|PROSITE-ProRule:PRU01122};
GN ORFNames=NPH_3406 {ECO:0000313|EMBL:EFK09303.1};
OS delta proteobacterium NaphS2.
OC Bacteria; Deltaproteobacteria.
OX NCBI_TaxID=88274 {ECO:0000313|EMBL:EFK09303.1, ECO:0000313|Proteomes:UP000003834};
RN [1] {ECO:0000313|EMBL:EFK09303.1, ECO:0000313|Proteomes:UP000003834}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NaphS2 {ECO:0000313|EMBL:EFK09303.1,
RC ECO:0000313|Proteomes:UP000003834};
RX PubMed=21124915; DOI=10.1371/journal.pone.0014072;
RA Didonato R.J., Young N.D., Butler J.E., Chin K.J., Hixson K.K., Mouser P.,
RA Lipton M.S., Deboy R., Methe B.A.;
RT "Genome Sequence of the Deltaproteobacterial Strain NaphS2 and Analysis of
RT Differential Gene Expression during Anaerobic Growth on Naphthalene.";
RL PLoS ONE 5:E14072-E14072(2010).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Hydrolysis of proteins in presence of ATP.; EC=3.4.21.53;
CC Evidence={ECO:0000256|PROSITE-ProRule:PRU01122};
CC -!- SIMILARITY: Belongs to the peptidase S16 family. {ECO:0000256|PROSITE-
CC ProRule:PRU01122}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EFK09303.1}.
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DR EMBL; ADZZ01000305; EFK09303.1; -; Genomic_DNA.
DR AlphaFoldDB; D8F4L6; -.
DR OrthoDB; 9758568at2; -.
DR Proteomes; UP000003834; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0004176; F:ATP-dependent peptidase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0030163; P:protein catabolic process; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 1.10.8.60; -; 1.
DR Gene3D; 3.30.230.10; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR041699; AAA_32.
DR InterPro; IPR046844; Lon-like_helical.
DR InterPro; IPR008269; Lon_proteolytic.
DR InterPro; IPR027065; Lon_Prtase.
DR InterPro; IPR046843; LonB_AAA-LID.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR002885; Pentatricopeptide_rpt.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR PANTHER; PTHR10046:SF46; ARCHAEAL LON PROTEASE; 1.
DR PANTHER; PTHR10046; ATP DEPENDENT LON PROTEASE FAMILY MEMBER; 1.
DR Pfam; PF13654; AAA_32; 1.
DR Pfam; PF05362; Lon_C; 1.
DR Pfam; PF20436; LonB_AAA-LID; 1.
DR Pfam; PF20437; LonC_helical; 1.
DR PRINTS; PR00830; ENDOLAPTASE.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR PROSITE; PS51786; LON_PROTEOLYTIC; 1.
DR PROSITE; PS51375; PPR; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Hydrolase {ECO:0000256|PROSITE-ProRule:PRU01122};
KW Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|PROSITE-
KW ProRule:PRU01122}; Reference proteome {ECO:0000313|Proteomes:UP000003834};
KW Serine protease {ECO:0000256|PROSITE-ProRule:PRU01122}.
FT DOMAIN 578..773
FT /note="Lon proteolytic"
FT /evidence="ECO:0000259|PROSITE:PS51786"
FT COILED 222..256
FT /evidence="ECO:0000256|SAM:Coils"
FT ACT_SITE 668
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01122"
FT ACT_SITE 711
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01122"
SQ SEQUENCE 827 AA; 93076 MW; BC0320C74FADD757 CRC64;
MPKKTSHKEV PTDKLRWRLD PATLPFKSTD DLEPLDEIVG QKRAVEAFRF GLGIESHGYN
VFVTGLAGTG RMSTVRKLLE EMSRNERVPD DLCYINNFKN TEAPILLRLK GGEGAAFKKD
IHDFVELLKK QIPMLFESQE YINTKKELMA AYEARGKSFF KNLDEKVKEE GFTLVDVQVG
QIKRPEVMPL VDGNPIHIDQ VEAMVEKGRF PKDEFEQMKE KHGKLRERVE QIFIELRDLQ
KEVQEKIEEM DRLTFLNNAS DMAKPLTEKY DHPKIQAYLK AMLEDMGENL QIFNPQQQQA
QVPGLMIPMA SEGDRFQPYQ INLLVDNSEQ KSSPVIVEDY PTYRNIFGSI ERIVDRAGVW
RTDFSKIKAG SLLKAQGGYL VINLMDAIVE PGVWQALKRA LKSEKLEIQT YDPFYLFTTS
GLKPEPIDLD IKVVVVADAY LYHLLLFYDP DMSKVFKVRA DFDTAMDKNE ESIVQISRFI
KMKGDEEKLK PFDRTAVAVL VEQAVRMTGR QEKISTSFPQ LTDYLREASY LADQEKEKIV
RDHHVEKVLE SRKFRSGMVE EHIQEMIDRG TLMIDVAGEA VGQVNGLAVY SMGDYAFGKP
SRITCSTAMG RAGIINIERE ADLSGSTHNK GVLILGGYLR KKYAQDKPLT MSASIAFEQS
YGGVDGDSAS STEIYALLSS LSEVPIKQYI AVTGSVNQNG QVQAIGGVNE KIEGFFDCCR
KKGADKSQGV MIPESNVKDL MLRQDVVNAV KDGKFHIYPV STIDEGIEIL TGKKAGKRKA
DGTYTKGSIN QLVDDKLKSL AEGLKNFAGD KEEGNKESKK KGCAQCS
//
