ID D8FG69_9DELT Unreviewed; 481 AA.
AC D8FG69;
DT 05-OCT-2010, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2010, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE SubName: Full=Putative gamma-aminobutyrate metabolism dehydratase/isomerase {ECO:0000313|EMBL:EFK05221.1};
GN ORFNames=NPH_0317 {ECO:0000313|EMBL:EFK05221.1};
OS delta proteobacterium NaphS2.
OC Bacteria; Deltaproteobacteria.
OX NCBI_TaxID=88274 {ECO:0000313|EMBL:EFK05221.1, ECO:0000313|Proteomes:UP000003834};
RN [1] {ECO:0000313|EMBL:EFK05221.1, ECO:0000313|Proteomes:UP000003834}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NaphS2 {ECO:0000313|EMBL:EFK05221.1,
RC ECO:0000313|Proteomes:UP000003834};
RX PubMed=21124915; DOI=10.1371/journal.pone.0014072;
RA Didonato R.J., Young N.D., Butler J.E., Chin K.J., Hixson K.K., Mouser P.,
RA Lipton M.S., Deboy R., Methe B.A.;
RT "Genome Sequence of the Deltaproteobacterial Strain NaphS2 and Analysis of
RT Differential Gene Expression during Anaerobic Growth on Naphthalene.";
RL PLoS ONE 5:E14072-E14072(2010).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EFK05221.1}.
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DR EMBL; ADZZ01000803; EFK05221.1; -; Genomic_DNA.
DR AlphaFoldDB; D8FG69; -.
DR OrthoDB; 7233724at2; -.
DR Proteomes; UP000003834; Unassembled WGS sequence.
DR GO; GO:0016853; F:isomerase activity; IEA:UniProtKB-KW.
DR GO; GO:0016627; F:oxidoreductase activity, acting on the CH-CH group of donors; IEA:InterPro.
DR Gene3D; 1.10.3140.10; 4-hydroxybutyryl-coa dehydratase, domain 1; 1.
DR Gene3D; 2.40.110.10; Butyryl-CoA Dehydrogenase, subunit A, domain 2; 1.
DR Gene3D; 1.20.140.10; Butyryl-CoA Dehydrogenase, subunit A, domain 3; 1.
DR InterPro; IPR046373; Acyl-CoA_Oxase/DH_mid-dom_sf.
DR InterPro; IPR036250; AcylCo_DH-like_C.
DR InterPro; IPR009100; AcylCoA_DH/oxidase_NM_dom_sf.
DR InterPro; IPR004925; HpaB/PvcC/4-BUDH.
DR InterPro; IPR024719; HpaB/PvcC/4-BUDH_C.
DR InterPro; IPR024674; HpaB/PvcC/4-BUDH_N.
DR PANTHER; PTHR36117; 4-HYDROXYPHENYLACETATE 3-MONOOXYGENASE-RELATED; 1.
DR PANTHER; PTHR36117:SF3; 4-HYDROXYPHENYLACETATE 3-MONOOXYGENASE-RELATED; 1.
DR Pfam; PF03241; HpaB; 1.
DR Pfam; PF11794; HpaB_N; 1.
DR PIRSF; PIRSF000331; HpaA_HpaB; 1.
DR SUPFAM; SSF47203; Acyl-CoA dehydrogenase C-terminal domain-like; 1.
DR SUPFAM; SSF56645; Acyl-CoA dehydrogenase NM domain-like; 1.
PE 4: Predicted;
KW FAD {ECO:0000256|PIRSR:PIRSR000331-2};
KW Flavoprotein {ECO:0000256|ARBA:ARBA00022630};
KW Isomerase {ECO:0000313|EMBL:EFK05221.1};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000003834}.
FT DOMAIN 5..275
FT /note="HpaB/PvcC/4-BUDH N-terminal"
FT /evidence="ECO:0000259|Pfam:PF11794"
FT DOMAIN 283..477
FT /note="HpaB/PvcC/4-BUDH C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03241"
FT BINDING 190
FT /ligand="FAD"
FT /ligand_id="ChEBI:CHEBI:57692"
FT /evidence="ECO:0000256|PIRSR:PIRSR000331-2"
SQ SEQUENCE 481 AA; 53267 MW; 950B6145DEE25CB8 CRC64;
MAIKTEKEYR ERVGKLKPRL FMGGKKVENL MEHPVTRAVI DATARVYGLT MDPAHADVMT
AESHLTGETI SRALHIHQSK EDLFKRLDMA RLSSQKLGTC NYRCPGNEML PSLAATTWEI
DHDKGTQYHG RFNDYMRYAQ EHDLVVSGSV TDPKGDRSKR PLEQDPDLYI RVVEKRSDGI
IVNGAKQHAT GAYAADETLV LPGISSRAGE EDYAVAFVVP NGTPGVTYIG QYNPFSAERE
CETDIRFLGN PAYGQRETCL VVFDHVFVPW DRVFMCGEVE YTQKFITRFA KTHRMNCGGA
CKVGFMDLII GAAKLMAEYN GLTNASHIAQ KITRMLQLND TSLACATAAA YFGKEEPEGS
GVFMPDETMG NIAKLNTNDG FWEVLALAGD ISGGIPATMP SEKELENPEV KAYVAKYLKA
AAPAEKRMRI SRFLQNWVAG LHGLGTYQGS GPSQSQYVSI YRVADLESKK RMALDLANMV
S
//
