ID D8JS23_HYPDA Unreviewed; 453 AA.
AC D8JS23;
DT 05-OCT-2010, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2010, sequence version 1.
DT 27-MAR-2024, entry version 65.
DE SubName: Full=Transcriptional regulator, GntR family with aminotransferase domain protein {ECO:0000313|EMBL:ADJ22282.1};
GN OrderedLocusNames=Hden_0461 {ECO:0000313|EMBL:ADJ22282.1};
OS Hyphomicrobium denitrificans (strain ATCC 51888 / DSM 1869 / NCIMB 11706 /
OS TK 0415).
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Hyphomicrobiales;
OC Hyphomicrobiaceae; Hyphomicrobium.
OX NCBI_TaxID=582899 {ECO:0000313|EMBL:ADJ22282.1, ECO:0000313|Proteomes:UP000002033};
RN [1] {ECO:0000313|Proteomes:UP000002033}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 51888 / DSM 1869 / NCIB 11706 / TK 0415
RC {ECO:0000313|Proteomes:UP000002033};
RX PubMed=21705585; DOI=10.1128/JB.05453-11;
RG US DOE Joint Genome Institute;
RA Brown P.J., Kysela D.T., Buechlein A., Hemmerich C., Brun Y.V.;
RT "Genome sequences of eight morphologically diverse alphaproteobacteria.";
RL J. Bacteriol. 193:4567-4568(2011).
CC -!- SIMILARITY: In the C-terminal section; belongs to the class-I
CC pyridoxal-phosphate-dependent aminotransferase family.
CC {ECO:0000256|ARBA:ARBA00005384}.
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DR EMBL; CP002083; ADJ22282.1; -; Genomic_DNA.
DR AlphaFoldDB; D8JS23; -.
DR STRING; 582899.Hden_0461; -.
DR KEGG; hdn:Hden_0461; -.
DR eggNOG; COG1167; Bacteria.
DR HOGENOM; CLU_017584_0_0_5; -.
DR Proteomes; UP000002033; Chromosome.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
DR GO; GO:0008483; F:transaminase activity; IEA:UniProtKB-KW.
DR GO; GO:0009058; P:biosynthetic process; IEA:InterPro.
DR CDD; cd00609; AAT_like; 1.
DR CDD; cd07377; WHTH_GntR; 1.
DR Gene3D; 3.90.1150.10; Aspartate Aminotransferase, domain 1; 1.
DR Gene3D; 3.40.640.10; Type I PLP-dependent aspartate aminotransferase-like (Major domain); 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR004839; Aminotransferase_I/II.
DR InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR InterPro; IPR015422; PyrdxlP-dep_Trfase_small.
DR InterPro; IPR000524; Tscrpt_reg_HTH_GntR.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR46577; HTH-TYPE TRANSCRIPTIONAL REGULATORY PROTEIN GABR; 1.
DR PANTHER; PTHR46577:SF1; HTH-TYPE TRANSCRIPTIONAL REGULATORY PROTEIN GABR; 1.
DR Pfam; PF00155; Aminotran_1_2; 1.
DR Pfam; PF00392; GntR; 1.
DR SMART; SM00345; HTH_GNTR; 1.
DR SUPFAM; SSF53383; PLP-dependent transferases; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS50949; HTH_GNTR; 1.
PE 3: Inferred from homology;
KW Aminotransferase {ECO:0000313|EMBL:ADJ22282.1};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Pyridoxal phosphate {ECO:0000256|ARBA:ARBA00022898};
KW Reference proteome {ECO:0000313|Proteomes:UP000002033};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Transferase {ECO:0000313|EMBL:ADJ22282.1}.
FT DOMAIN 6..74
FT /note="HTH gntR-type"
FT /evidence="ECO:0000259|PROSITE:PS50949"
SQ SEQUENCE 453 AA; 48358 MW; F26331517CBF86FD CRC64;
MAEGGELKSI GIVDALEADI RAGRVPPGSR LPPQRAIAKA LGVDLTTVTR AFNEARRRGL
IDGKVGSGTF VRRLESGGSE LFAAPAVDLS LNIPPQPAAA GLRHLIPETI ADLLASEQGM
LHLRYQESAG SVPDRAAGAI WLGDRIGDVK PSSLLLASGA QSALFAVCDC LVRPGETIAA
GLVTYPGLTA IAQQRGYVLQ PVAMDEDGII PESFSELCER AAPKALYVVP SIDNPTTATL
PEARRREIAR IAREYRVALI EDDPYSSLLK HAPASFADLA PELTWHIETL SKCATPALRI
AYVLAPSDAQ ALRLAGVLRA MNLMAPPLNA AVASRWITTG RLDDIRNAIR EEAAARQAIA
RSLLGRFVYQ SDPHGHHVWL TMPPYWRAVD LASHAERAGF AVVPSSEFAV SRTHPEAVRI
SLGVAGDRDS LTQALKLLAE LLAQPVLPSK AIV
//
