ID D8JUG2_HYPDA Unreviewed; 463 AA.
AC D8JUG2;
DT 05-OCT-2010, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2010, sequence version 1.
DT 27-MAR-2024, entry version 59.
DE SubName: Full=Efflux transporter, RND family, MFP subunit {ECO:0000313|EMBL:ADJ22752.1};
GN OrderedLocusNames=Hden_0938 {ECO:0000313|EMBL:ADJ22752.1};
OS Hyphomicrobium denitrificans (strain ATCC 51888 / DSM 1869 / NCIMB 11706 /
OS TK 0415).
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Hyphomicrobiales;
OC Hyphomicrobiaceae; Hyphomicrobium.
OX NCBI_TaxID=582899 {ECO:0000313|EMBL:ADJ22752.1, ECO:0000313|Proteomes:UP000002033};
RN [1] {ECO:0000313|Proteomes:UP000002033}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 51888 / DSM 1869 / NCIB 11706 / TK 0415
RC {ECO:0000313|Proteomes:UP000002033};
RX PubMed=21705585; DOI=10.1128/JB.05453-11;
RG US DOE Joint Genome Institute;
RA Brown P.J., Kysela D.T., Buechlein A., Hemmerich C., Brun Y.V.;
RT "Genome sequences of eight morphologically diverse alphaproteobacteria.";
RL J. Bacteriol. 193:4567-4568(2011).
CC -!- SIMILARITY: Belongs to the membrane fusion protein (MFP) (TC 8.A.1)
CC family. {ECO:0000256|ARBA:ARBA00009477}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CP002083; ADJ22752.1; -; Genomic_DNA.
DR AlphaFoldDB; D8JUG2; -.
DR STRING; 582899.Hden_0938; -.
DR KEGG; hdn:Hden_0938; -.
DR eggNOG; COG0845; Bacteria.
DR HOGENOM; CLU_018816_2_0_5; -.
DR OrthoDB; 8435523at2; -.
DR Proteomes; UP000002033; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR Gene3D; 2.40.30.170; -; 1.
DR Gene3D; 2.40.420.20; -; 1.
DR Gene3D; 2.40.50.100; -; 1.
DR Gene3D; 1.10.287.470; Helix hairpin bin; 1.
DR InterPro; IPR032317; HlyD_D23.
DR InterPro; IPR006143; RND_pump_MFP.
DR NCBIfam; TIGR01730; RND_mfp; 1.
DR PANTHER; PTHR30469; MULTIDRUG RESISTANCE PROTEIN MDTA; 1.
DR PANTHER; PTHR30469:SF12; MULTIDRUG RESISTANCE PROTEIN MDTA; 1.
DR Pfam; PF16576; HlyD_D23; 1.
DR SUPFAM; SSF111369; HlyD-like secretion proteins; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002033};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 7..24
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 72..291
FT /note="RND efflux pump membrane fusion protein barrel-
FT sandwich"
FT /evidence="ECO:0000259|Pfam:PF16576"
FT REGION 369..463
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 398..463
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 463 AA; 48464 MW; FE4CB8555B15984E CRC64;
MKLMRSIFTL LVIGAIGGGV YYVMQSGSPG GTAKPRFGRD GGGGPVAVIA KPAETADVPI
YLEGVGSVRA LNLATVRAQV DGILLSVNFK EGQDVKRGDV LAKIDPVTYQ AQLDQAIAKK
ALDEALLANT KRDLERYQKV GTLAISQQQI DTQKALAQQQ EAQIKSDTAA IENATAILGY
TTIVAPFDGR TGIRIVDQGN LVHAGDTGGI VVITQIQPIS VVFTLPQQDL PALTGATGKL
TAQALSTNSQ TELDSGLLEV IDNQVDQQTG TIRLKANFPN DRRQLWPGQF VNVRVLVDTM
KNVVVAPTEA IQRGPDGDYV YVVQADKTVA MRAVKIARQD EKQAVIAEGV KSGDTLVVNG
FGRLKDGATV AVSDGKTPPA SADAPAKQRH RQGGKAAGDT SDRQQSSASQ SGAPSGAQSG
AQASAPLITG SNTEPTRTVD SSKPGTRPDQ QPRGNAKDGG TSP
//
