ID D8K4X5_NITWC Unreviewed; 742 AA.
AC D8K4X5;
DT 05-OCT-2010, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2010, sequence version 1.
DT 27-MAR-2024, entry version 54.
DE SubName: Full=Peptidase S8 and S53 subtilisin kexin sedolisin {ECO:0000313|EMBL:ADJ27952.1};
GN OrderedLocusNames=Nwat_1010 {ECO:0000313|EMBL:ADJ27952.1};
OS Nitrosococcus watsoni (strain C-113).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Chromatiales; Chromatiaceae;
OC Nitrosococcus.
OX NCBI_TaxID=105559 {ECO:0000313|EMBL:ADJ27952.1, ECO:0000313|Proteomes:UP000000393};
RN [1] {ECO:0000313|EMBL:ADJ27952.1, ECO:0000313|Proteomes:UP000000393}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C-113 {ECO:0000313|EMBL:ADJ27952.1,
RC ECO:0000313|Proteomes:UP000000393};
RG US DOE Joint Genome Institute;
RA Lucas S., Copeland A., Lapidus A., Cheng J.-F., Bruce D., Goodwin L.,
RA Pitluck S., Malfatti S.A., Chain P.S.G., Land M., Hauser L., Kyrpides N.,
RA Ivanova N., Cambell M.A., Heidelberg J.F., Klotz M.G., Woyke T.;
RT "Complete sequence of chromosome of Nitrosococcus watsoni C-113.";
RL Submitted (JUN-2010) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the peptidase S8 family.
CC {ECO:0000256|ARBA:ARBA00011073, ECO:0000256|PROSITE-ProRule:PRU01240,
CC ECO:0000256|RuleBase:RU003355}.
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DR EMBL; CP002086; ADJ27952.1; -; Genomic_DNA.
DR RefSeq; WP_013220054.1; NC_014315.1.
DR AlphaFoldDB; D8K4X5; -.
DR STRING; 105559.Nwat_1010; -.
DR KEGG; nwa:Nwat_1010; -.
DR eggNOG; COG1404; Bacteria.
DR HOGENOM; CLU_374219_0_0_6; -.
DR OrthoDB; 9790784at2; -.
DR Proteomes; UP000000393; Chromosome.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd07496; Peptidases_S8_13; 1.
DR Gene3D; 3.40.50.200; Peptidase S8/S53 domain; 1.
DR InterPro; IPR043708; DUF5648.
DR InterPro; IPR000209; Peptidase_S8/S53_dom.
DR InterPro; IPR036852; Peptidase_S8/S53_dom_sf.
DR InterPro; IPR023827; Peptidase_S8_Asp-AS.
DR InterPro; IPR022398; Peptidase_S8_His-AS.
DR InterPro; IPR023828; Peptidase_S8_Ser-AS.
DR InterPro; IPR015500; Peptidase_S8_subtilisin-rel.
DR InterPro; IPR034176; Peptidases_S8_13.
DR PANTHER; PTHR43806:SF59; CEREVISIN-RELATED; 1.
DR PANTHER; PTHR43806; PEPTIDASE S8; 1.
DR Pfam; PF18885; DUF5648; 1.
DR Pfam; PF00082; Peptidase_S8; 1.
DR PRINTS; PR00723; SUBTILISIN.
DR SUPFAM; SSF52743; Subtilisin-like; 1.
DR PROSITE; PS51892; SUBTILASE; 1.
DR PROSITE; PS00136; SUBTILASE_ASP; 1.
DR PROSITE; PS00137; SUBTILASE_HIS; 1.
DR PROSITE; PS00138; SUBTILASE_SER; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU01240};
KW Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|PROSITE-
KW ProRule:PRU01240};
KW Serine protease {ECO:0000256|ARBA:ARBA00022825, ECO:0000256|PROSITE-
KW ProRule:PRU01240}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..742
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003116632"
FT DOMAIN 239..527
FT /note="Peptidase S8/S53"
FT /evidence="ECO:0000259|Pfam:PF00082"
FT REGION 58..91
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 274..303
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 58..74
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 246
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01240"
FT ACT_SITE 305
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01240"
FT ACT_SITE 503
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01240"
SQ SEQUENCE 742 AA; 80668 MW; 5D16F7692268E9B9 CRC64;
MFKIRIYLGA CIFFSLILST TIATEQSLEK KGPSASKNEA LSRLMEKLLR EKSPLPLNLN
INHDTSTGNE ATVKSTEHTD SRADTPSSQA PQLPPAIAVG VIVRFKSPEI QALARDNLPP
PPEMVAELEA ALGEKLIFER ATVNEAYVFS FLAPKEGKEA IDAFLQPARE LPSIDWIEAN
QRVQMQSSSV RAQPSIAQAQ SFSNDPNFGD QWNMMSESEG VIGGIDAVHA WDITHGSPDT
IVAVVDTGVL SHPEFADRLL PGYDFVSNPF HANDGDGRDS DASDPGDWVN KGECSRNHDE
PSSWHGTHVA GIIAASGDDG YGIAGVNWKT RILPVRVLGT CNGTDGDIIE GMMWAAGLPV
PGVPDNPNPA QVINLSVGGP GLSCPFSYSQ AIDKIVSRGV SIIVAAGNKG FREDNSNALY
SVPANCFDVF VVVATNPSGE PAGYTYKQPF YNISTAISAP GGDMGEWIEG IGYTHKEDGI
LSTIGLGAKE PQGYDYQWYH GTSMAAPHVS GIASLVLAVN PNLSGIELYP LLRFASRPFS
EGGSCDDYGT SMCGSGIADA YRSVEFAEVL KNYRLVYEFS NVISDHYMLT ASKEDVALLY
QGGEGLEGWY NTRKYSYAWS GPEEGAVPVC RFYTLGANSH FYTANAEDCA YLKTLNPDNI
YADDKWTYED IAFYAKLPTN GICPADSAPI YRVYNNRWMY NDSNHRFVSS DSMRRVMLDK
GWVDEGVAFC AAFVQDSLTF LD
//
