ID D8LJQ2_ECTSI Unreviewed; 547 AA.
AC D8LJQ2;
DT 05-OCT-2010, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2010, sequence version 1.
DT 27-MAR-2024, entry version 49.
DE SubName: Full=Sulfotransferase {ECO:0000313|EMBL:CBN77079.1};
DE EC=2.8.2.- {ECO:0000313|EMBL:CBN77079.1};
GN ORFNames=Esi_0026_0167 {ECO:0000313|EMBL:CBN77079.1};
OS Ectocarpus siliculosus (Brown alga) (Conferva siliculosa).
OC Eukaryota; Sar; Stramenopiles; Ochrophyta; PX clade; Phaeophyceae;
OC Ectocarpales; Ectocarpaceae; Ectocarpus.
OX NCBI_TaxID=2880 {ECO:0000313|EMBL:CBN77079.1, ECO:0000313|Proteomes:UP000002630};
RN [1] {ECO:0000313|EMBL:CBN77079.1, ECO:0000313|Proteomes:UP000002630}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Ec32 / CCAP1310/4 {ECO:0000313|Proteomes:UP000002630};
RX PubMed=20520714; DOI=10.1038/nature09016;
RA Cock J.M., Sterck L., Rouze P., Scornet D., Allen A.E., Amoutzias G.,
RA Anthouard V., Artiguenave F., Aury J.M., Badger J.H., Beszteri B.,
RA Billiau K., Bonnet E., Bothwell J.H., Bowler C., Boyen C., Brownlee C.,
RA Carrano C.J., Charrier B., Cho G.Y., Coelho S.M., Collen J., Corre E.,
RA Da Silva C., Delage L., Delaroque N., Dittami S.M., Doulbeau S., Elias M.,
RA Farnham G., Gachon C.M., Gschloessl B., Heesch S., Jabbari K., Jubin C.,
RA Kawai H., Kimura K., Kloareg B., Kupper F.C., Lang D., Le Bail A.,
RA Leblanc C., Lerouge P., Lohr M., Lopez P.J., Martens C., Maumus F.,
RA Michel G., Miranda-Saavedra D., Morales J., Moreau H., Motomura T.,
RA Nagasato C., Napoli C.A., Nelson D.R., Nyvall-Collen P., Peters A.F.,
RA Pommier C., Potin P., Poulain J., Quesneville H., Read B., Rensing S.A.,
RA Ritter A., Rousvoal S., Samanta M., Samson G., Schroeder D.C., Segurens B.,
RA Strittmatter M., Tonon T., Tregear J.W., Valentin K., von Dassow P.,
RA Yamagishi T., Van de Peer Y., Wincker P.;
RT "The Ectocarpus genome and the independent evolution of multicellularity in
RT brown algae.";
RL Nature 465:617-621(2010).
CC -!- SIMILARITY: Belongs to the aspartyl/asparaginyl beta-hydroxylase
CC family. {ECO:0000256|ARBA:ARBA00007730}.
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DR EMBL; FN648442; CBN77079.1; -; Genomic_DNA.
DR AlphaFoldDB; D8LJQ2; -.
DR EnsemblProtists; CBN77079; CBN77079; Esi_0026_0167.
DR eggNOG; ENOG502QU6N; Eukaryota.
DR InParanoid; D8LJQ2; -.
DR OMA; FEQINIP; -.
DR OrthoDB; 89741at2759; -.
DR Proteomes; UP000002630; Chromosome LG12.
DR GO; GO:0008146; F:sulfotransferase activity; IEA:InterPro.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR007803; Asp/Arg/Pro-Hydrxlase.
DR InterPro; IPR027443; IPNS-like_sf.
DR InterPro; IPR037359; NST/OST.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000863; Sulfotransferase_dom.
DR PANTHER; PTHR10605:SF56; BIFUNCTIONAL HEPARAN SULFATE N-DEACETYLASE_N-SULFOTRANSFERASE; 1.
DR PANTHER; PTHR10605; HEPARAN SULFATE SULFOTRANSFERASE; 1.
DR Pfam; PF05118; Asp_Arg_Hydrox; 1.
DR Pfam; PF00685; Sulfotransfer_1; 1.
DR SUPFAM; SSF51197; Clavaminate synthase-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000002630};
KW Transferase {ECO:0000313|EMBL:CBN77079.1}.
FT DOMAIN 138..229
FT /note="Aspartyl/asparaginy/proline hydroxylase"
FT /evidence="ECO:0000259|Pfam:PF05118"
FT DOMAIN 265..480
FT /note="Sulfotransferase"
FT /evidence="ECO:0000259|Pfam:PF00685"
FT REGION 498..517
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 274
FT /note="For sulfotransferase activity"
FT /evidence="ECO:0000256|PIRSR:PIRSR637359-1"
FT BINDING 370
FT /ligand="3'-phosphoadenylyl sulfate"
FT /ligand_id="ChEBI:CHEBI:58339"
FT /evidence="ECO:0000256|PIRSR:PIRSR637359-2"
FT BINDING 378
FT /ligand="3'-phosphoadenylyl sulfate"
FT /ligand_id="ChEBI:CHEBI:58339"
FT /evidence="ECO:0000256|PIRSR:PIRSR637359-2"
SQ SEQUENCE 547 AA; 61918 MW; B604C6F929D34A10 CRC64;
MMAAMVSAAP RNVGGEILVP PSGQVKLKDK TTPVIEQVAK EQLDPEARPL VFTRGRADLS
LLKLLLSSRG ASIWTDEEHD RTNVKMTRPA HDKWGISKIV LVFCDDFLKR VYTFPWYHEP
EWKEALQPVL DVLGIPEEKM VRCLLASMPP GCVIPVHHDT GHWVQHTHRV HVAVVTDVSE
VDFLVGPDPK HMRKVMFDEG RVVEFNNQAK HAVTNRWSRN RVHLILDYVD EYPLDFVRLA
PGSKLVQTRR SIDVEGLVTR QGPDPAFVVL GGQKCGTTLL YECLNQHPLV ARGRRRETHF
FDWAWPAKGE SLTVDQLRES YMAFFYAEEL KSHPSIVTGE STPSYLLRGD LVIPRLKNVA
GKTRLLVMLR DPVKRAYSHY HMAVDPEGTP AQLRSRGGGG WTSKTFEQVV EEERAVLEKA
GVGPATSPGD FARDYLSTRP NGYGGHSLLG RGLYALQLQP WLEAFGRDQI KVLFLEEVVK
SEDSLQEAMD GVFEHVGLPP SPVEDKAPKN HRDYPPMDEG VRRRLRDFYA PYDAALRQLL
RRDSLPW
//
