ID   D8LYD6_BLAHO            Unreviewed;       861 AA.
AC   D8LYD6;
DT   05-OCT-2010, integrated into UniProtKB/TrEMBL.
DT   05-OCT-2010, sequence version 1.
DT   13-SEP-2023, entry version 41.
DE   RecName: Full=Upf1 domain-containing protein {ECO:0000259|PROSITE:PS51997};
GN   ORFNames=GSBLH_T00000896001 {ECO:0000313|EMBL:CBK20591.2};
OS   Blastocystis hominis.
OC   Eukaryota; Sar; Stramenopiles; Bigyra; Opalozoa; Opalinata; Blastocystidae;
OC   Blastocystis.
OX   NCBI_TaxID=12968 {ECO:0000313|EMBL:CBK20591.2};
RN   [1] {ECO:0000313|EMBL:CBK20591.2}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Singapore isolate B {ECO:0000313|EMBL:CBK20591.2};
RA   Wincker P.;
RT   "Sequencing and annotation of the Blastocystis hominis genome.";
RL   Submitted (FEB-2010) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|PROSITE-ProRule:PRU01341}.
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DR   EMBL; FN668639; CBK20591.2; -; Genomic_DNA.
DR   RefSeq; XP_012894639.1; XM_013039185.1.
DR   AlphaFoldDB; D8LYD6; -.
DR   EnsemblProtists; CBK20591; CBK20591; GSBLH_T00000896001.
DR   GeneID; 24918183; -.
DR   InParanoid; D8LYD6; -.
DR   OMA; VRSNDNQ; -.
DR   OrthoDB; 170190at2759; -.
DR   Proteomes; UP000008312; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR   GO; GO:0003724; F:RNA helicase activity; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0000184; P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; IEA:InterPro.
DR   CDD; cd18039; DEXXQc_UPF1; 1.
DR   CDD; cd18808; SF1_C_Upf1; 1.
DR   CDD; cd21400; ZBD_UPF1-like; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR   InterPro; IPR045055; DNA2/NAM7-like.
DR   InterPro; IPR041679; DNA2/NAM7-like_C.
DR   InterPro; IPR041677; DNA2/NAM7_AAA_11.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR047187; SF1_C_Upf1.
DR   InterPro; IPR018999; UPF1_CH/ZBD.
DR   PANTHER; PTHR10887; DNA2/NAM7 HELICASE FAMILY; 1.
DR   PANTHER; PTHR10887:SF364; REGULATOR OF NONSENSE TRANSCRIPTS 1; 1.
DR   Pfam; PF13086; AAA_11; 2.
DR   Pfam; PF13087; AAA_12; 1.
DR   Pfam; PF09416; UPF1_Zn_bind; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS51997; UPF1_CH_RICH; 1.
PE   4: Predicted;
KW   Metal-binding {ECO:0000256|PROSITE-ProRule:PRU01341};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008312};
KW   Zinc {ECO:0000256|PROSITE-ProRule:PRU01341};
KW   Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU01341}.
FT   DOMAIN          15..167
FT                   /note="Upf1"
FT                   /evidence="ECO:0000259|PROSITE:PS51997"
FT   REGION          23..55
FT                   /note="C3H"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU01341"
FT   REGION          37..65
FT                   /note="CC/SHH/C"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU01341"
SQ   SEQUENCE   861 AA;  98336 MW;  E83E2C7A7432FD74 CRC64;
     MAKKVKQDND AGEEIVEAST IQCDYCKNRT GSSLVFCRIC KRWFCNSTDV RQGSHIFLHM
     SYTRHYQALS HKESVLKGSR FKCSCGNSNI FDLYYRMVNG AVKIRCLPSC LSKNALEDKA
     FDMDLWKPIV DDRRLTPAIC TIPNVTEYCS ILSAQRISQY EHQRIANKSL RIEDVVVNDY
     SQVRHTQQEY DDSLAYYKVF EPLIRIEEYD QRQSSLVDGD KHVYVSFFRE HHKQGYHPVA
     VFEIHMTEYS RGITQWDNLE DLDQDQDDEY FEKKKSSQGS KCNRADEHEN LVEMMENQNQ
     LDEEILQTND YENLLTSRIE YTGKVKKIKS IRPEVNLFEC RLVITSKEIP RNVSAYKNGY
     YDVRLQEAGT SAARRLTAIK LLDDEKAISQ HIYNIFLGNK SMMNKREFYV SHRDREVSFD
     APNLRPLNRS QHDAIAYALQ SEFTLIQGPP GTGKTAYRND PKHLWRFKTP GPVLVCTPSN
     VAADEICARI HRTGVNVVRL MAVSKESMES PVQELCVHIK ARELMKAEAS ELLAIQTRHD
     DGEEIEEADW RHFMKESGKY KRRVIQSADV VVSTCDSAGS PLLSGCVFNS VLVDEASQAT
     ECETLIPIVH GAHRVVLVGD QKQLQPVVLS AVCKRAGYDV SLFERLIDSG MEPQLLCVQY
     RMHPALSVFS NHKFYEGRLE DGIGEANRPL IKFCYPNTKV PLLFWNVKGR ESIGNTGSSF
     LNVQEATAVV NIVKELMQCG IKEKKIGVIT SYTGQKVLLK NLLQQSRLGK VECASVNTFQ
     GREMDYIVLS CVRSNPMRII GFLKDPKRLN VALTRARFGM IIVGDTSVLK YNDLWKEYLS
     YHQALNTLVD GSIGHWQVSA L
//