ID D8PGN0_9BACT Unreviewed; 731 AA.
AC D8PGN0;
DT 05-OCT-2010, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2010, sequence version 1.
DT 27-MAR-2024, entry version 59.
DE SubName: Full=Putative Tyrosine-protein kinase Etk {ECO:0000313|EMBL:CBK42417.1};
DE EC=2.7.10.- {ECO:0000313|EMBL:CBK42417.1};
GN ORFNames=NIDE2711 {ECO:0000313|EMBL:CBK42417.1};
OS Nitrospira defluvii.
OC Bacteria; Nitrospirota; Nitrospiria; Nitrospirales; Nitrospiraceae;
OC Nitrospira.
OX NCBI_TaxID=330214 {ECO:0000313|EMBL:CBK42417.1, ECO:0000313|Proteomes:UP000001660};
RN [1] {ECO:0000313|EMBL:CBK42417.1, ECO:0000313|Proteomes:UP000001660}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20624973; DOI=10.1073/pnas.1003860107;
RA Lucker S., Wagner M., Maixner F., Pelletier E., Koch H., Vacherie B.,
RA Rattei T., Sinninghe Damste J., Spieck E., Le Paslier D., Daims H.;
RT "A Nitrospira metagenome illuminates the physiology and evolution of
RT globally important nitrite-oxidizing bacteria.";
RL Proc. Natl. Acad. Sci. U.S.A. 0:13479-13484(2010).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-
CC [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620, ChEBI:CHEBI:456216;
CC Evidence={ECO:0000256|ARBA:ARBA00001074};
CC -!- SUBCELLULAR LOCATION: Cell inner membrane
CC {ECO:0000256|ARBA:ARBA00004429}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004429}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the etk/wzc family.
CC {ECO:0000256|ARBA:ARBA00008883}.
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DR EMBL; FP929003; CBK42417.1; -; Genomic_DNA.
DR AlphaFoldDB; D8PGN0; -.
DR STRING; 330214.NIDE2711; -.
DR KEGG; nde:NIDE2711; -.
DR eggNOG; COG0489; Bacteria.
DR eggNOG; COG3206; Bacteria.
DR HOGENOM; CLU_009912_2_1_0; -.
DR Proteomes; UP000001660; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004713; F:protein tyrosine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0045226; P:extracellular polysaccharide biosynthetic process; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd05387; BY-kinase; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR025669; AAA_dom.
DR InterPro; IPR032807; GNVR.
DR InterPro; IPR003856; LPS_length_determ_N_term.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR005702; Wzc-like_C.
DR NCBIfam; TIGR01007; eps_fam; 1.
DR PANTHER; PTHR32309; TYROSINE-PROTEIN KINASE; 1.
DR PANTHER; PTHR32309:SF13; TYROSINE-PROTEIN KINASE ETK-RELATED; 1.
DR Pfam; PF13614; AAA_31; 1.
DR Pfam; PF13807; GNVR; 1.
DR Pfam; PF02706; Wzz; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Cell inner membrane {ECO:0000256|ARBA:ARBA00022519};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:CBK42417.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000001660};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:CBK42417.1};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW Tyrosine-protein kinase {ECO:0000256|ARBA:ARBA00023137}.
FT TRANSMEM 27..46
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 15..99
FT /note="Polysaccharide chain length determinant N-terminal"
FT /evidence="ECO:0000259|Pfam:PF02706"
FT DOMAIN 398..469
FT /note="Tyrosine kinase G-rich"
FT /evidence="ECO:0000259|Pfam:PF13807"
FT DOMAIN 551..685
FT /note="AAA"
FT /evidence="ECO:0000259|Pfam:PF13614"
SQ SEQUENCE 731 AA; 80566 MW; 393338606BB5EB27 CRC64;
MNAKAVMSDE SEHTLSEYAT ACWRHRWLIV LVVGCFGIGA AVWSFLQVPV FQAKATVVID
NPTPGGLDKD KSFYPDNSPE YFQTHFELMK SHFVLQRTAR LLDLAERPEY QPKPSAIKQF
LKSLLPDSVL AFVKPVKKEA VDSVDDAEEA LIKQFAQDIE IMPIRGARLA HVTANAIDPE
LAAQIANTLV SVYIERNQEL STNSKEQAAQ WFTGHLEELR QKVQNSQQAL YLFRAKHGLL
TGEERKTVAA HTLAELNSQL VKTEMAKAEA HSRFLQIRAV LNPQGAGTAG VDWSKLDSQI
QVLNSPLIQT LRAQEITVSA QVAELSEKYG ALHPKLAHMK AELQDLRQRI QQEVQKIYDS
VKHQYDMALA QDKAVKEAIT RYSSDKIRLE QNEIEHSMLE RDAETSQHLY DVFLKATKET
DLSSGLRANN VYLADPAAPS SVPSKPRTKL NIMLGLLAGL MSGVGLAIFV EGRSKKLMAP
ADVERYLPNV SLLGVVPLLS KSAAQEKALA PPNALTPVAE SFRIIRTSLL LSNPDMLPSR
ILITSPGENE GKTTLAVNLA MAMAQLEDTL VVLIDVDFRN QHIHPLYDVG SPEQPPKGLG
HLLRGEAGLD EVVHQTFVKN LSVIPHGGRP ANPTELLHSK SMAQLLKWGA TNRYHIILDC
PPVLPIADAA VLASKVDGVL LVVSAGETTR DACHLAVQRI KQAGGRLLGV VMQKAPVAES
SYYYGAYQQQ R
//
