ID D8PLR2_SCHCM Unreviewed; 2228 AA.
AC D8PLR2;
DT 05-OCT-2010, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2010, sequence version 1.
DT 27-MAR-2024, entry version 69.
DE RecName: Full=histidine kinase {ECO:0000256|ARBA:ARBA00012438};
DE EC=2.7.13.3 {ECO:0000256|ARBA:ARBA00012438};
GN ORFNames=SCHCODRAFT_13877 {ECO:0000313|EMBL:EFJ04101.1};
OS Schizophyllum commune (strain H4-8 / FGSC 9210) (Split gill fungus).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC Agaricomycetidae; Agaricales; Schizophyllaceae; Schizophyllum.
OX NCBI_TaxID=578458 {ECO:0000313|Proteomes:UP000007431};
RN [1] {ECO:0000313|EMBL:EFJ04101.1, ECO:0000313|Proteomes:UP000007431}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=H4-8 / FGSC 9210 {ECO:0000313|Proteomes:UP000007431};
RX PubMed=20622885; DOI=10.1038/nbt.1643;
RA Ohm R.A., de Jong J.F., Lugones L.G., Aerts A., Kothe E., Stajich J.E.,
RA de Vries R.P., Record E., Levasseur A., Baker S.E., Bartholomew K.A.,
RA Coutinho P.M., Erdmann S., Fowler T.J., Gathman A.C., Lombard V.,
RA Henrissat B., Knabe N., Kuees U., Lilly W.W., Lindquist E., Lucas S.,
RA Magnuson J.K., Piumi F., Raudaskoski M., Salamov A., Schmutz J.,
RA Schwarze F.W.M.R., vanKuyk P.A., Horton J.S., Grigoriev I.V.,
RA Woesten H.A.B.;
RT "Genome sequence of the model mushroom Schizophyllum commune.";
RL Nat. Biotechnol. 28:957-963(2010).
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DR EMBL; GL377302; EFJ04101.1; -; Genomic_DNA.
DR RefSeq; XP_003039003.1; XM_003038957.1.
DR STRING; 578458.D8PLR2; -.
DR VEuPathDB; FungiDB:SCHCODRAFT_02140343; -.
DR eggNOG; KOG0519; Eukaryota.
DR HOGENOM; CLU_000400_0_0_1; -.
DR InParanoid; D8PLR2; -.
DR OMA; FAIQATH; -.
DR OrthoDB; 1222064at2759; -.
DR Proteomes; UP000007431; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR CDD; cd16922; HATPase_EvgS-ArcB-TorS-like; 1.
DR CDD; cd00082; HisKA; 1.
DR CDD; cd17546; REC_hyHK_CKI1_RcsC-like; 1.
DR Gene3D; 1.10.287.130; -; 1.
DR Gene3D; 3.30.450.40; -; 1.
DR Gene3D; 3.40.50.2300; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR041664; AAA_16.
DR InterPro; IPR011006; CheY-like_superfamily.
DR InterPro; IPR003018; GAF.
DR InterPro; IPR029016; GAF-like_dom_sf.
DR InterPro; IPR003594; HATPase_C.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR005467; His_kinase_dom.
DR InterPro; IPR003661; HisK_dim/P.
DR InterPro; IPR036097; HisK_dim/P_sf.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR004358; Sig_transdc_His_kin-like_C.
DR InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR PANTHER; PTHR43719:SF28; PEROXIDE STRESS-ACTIVATED HISTIDINE KINASE MAK2; 1.
DR PANTHER; PTHR43719; TWO-COMPONENT HISTIDINE KINASE; 1.
DR Pfam; PF13191; AAA_16; 1.
DR Pfam; PF13185; GAF_2; 1.
DR Pfam; PF02518; HATPase_c; 1.
DR Pfam; PF00512; HisKA; 1.
DR Pfam; PF00072; Response_reg; 1.
DR PRINTS; PR00344; BCTRLSENSOR.
DR SMART; SM00065; GAF; 1.
DR SMART; SM00387; HATPase_c; 1.
DR SMART; SM00388; HisKA; 1.
DR SMART; SM00448; REC; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF52172; CheY-like; 1.
DR SUPFAM; SSF55781; GAF domain-like; 1.
DR SUPFAM; SSF47384; Homodimeric domain of signal transducing histidine kinase; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS50109; HIS_KIN; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS50110; RESPONSE_REGULATORY; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:EFJ04101.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553, ECO:0000256|PROSITE-
KW ProRule:PRU00169}; Reference proteome {ECO:0000313|Proteomes:UP000007431};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Two-component regulatory system {ECO:0000256|ARBA:ARBA00023012}.
FT DOMAIN 24..328
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT DOMAIN 1710..1918
FT /note="Histidine kinase"
FT /evidence="ECO:0000259|PROSITE:PS50109"
FT DOMAIN 2099..2222
FT /note="Response regulatory"
FT /evidence="ECO:0000259|PROSITE:PS50110"
FT REGION 389..445
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 2151
FT /note="4-aspartylphosphate"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00169"
SQ SEQUENCE 2228 AA; 245965 MW; 1C32288453D9EA83 CRC64;
MKRKFGHSAP TLYFRDGILS IPGYTLEKAL PWKDTGSLTL LAEGSSLKDG SSVLAKIAPA
QSNGSMCLER EAHILAKMAT FPEGNTTTLR MIDFFTIPKD AGDVVVLLLA HPGLNLLSRH
LPSSKINDLL LSEVMPATTA FGDVYMMGIE EPDLEEIESL EIIDLASFLE AGVFHREVRA
NAFHLNSHSG LVRLVHFGNR AVSLENFGSP SALVINAFHE HEKLRVKEAL CYLAPEQTGS
YETMTQDHRT DLYSLGILFW TLLVGRGQMP FEGDPLELLH AIVQKTPMPV HEVRRDVPQV
LAAIVAKLLE KHPDDRYQSA YGLKEDLIEC QRRLLAAVAS ATNENAELIP FFEIAKQDRF
MEFSLPIALF GREKELSTIS GVVKSLTSSQ PMSASGGSVV HHSSSEHSPK MSSTSASRTS
PSHDVTTSAS GHAPTATSAT PSDLRRTALR TKARSVRTHT IVIVGPPGVG KSSMVLANQA
EWRRYGVWGQ AKFQNIDAAP FSALLSCLSS VLRQLRVFST DLHRFVTALR QRLGPQLNNI
PLLYQGAPEL RDILAMFNIV LELPHEARDS NELRVRFQSL VVNVLAVVAE TRLFALFLDD
VHEADDSALD LISTIVNSKN RMLVFMTMRS DRPDAIDRVR QMFSSRSRPT WLNVEPLSFS
AVSILIARTL RRPRDDVAAL SRFIYNASSG NAFSARSLLT ALQRRGHIKF DWDRNYWIYD
MASIEGTLSS QGSANPTDLS FLTTQLRSLP SEARRYLLWA ALLGETFKVT DVASMMDKEE
SSSSGSEEDT DDVWSAHKAA PVTAPGAGRG SMRGLQTALT EGWLIQRARD MCSFAHDRYR
LAAQAELDSL RPEALAKMSF RIILQMMQQP SPDLYRIAEY SKRCLPLLTN HPKRDELLVL
LVDAGEDAWA RGAHELAIRS FESARTLLGD DPWKTKEDKK AFGVMLRLAA LYNWKGDYTA
SDGIIRDTLA HLDEPEDKAN MIRIQARNQF LRGNFAAALD DTLEALRLLN VPLQAAPTEK
EATDMFERVK NEILAVGYDQ ILAIPHTSES RSELTVTLLN DAGLNAYWSP SHDTFSEVIG
LTTMQLALRN GIATGTALGF LWALGGAAER RGQYRLSVAL GNVALRLAER YGGSAEKCTA
QVLYTALVSG FANVHLRVNI AKLEEAIKYG YSAGDRLFTG YALIYTVQNK LYVCEHISEL
ITTAEDCVAD LKLWASSGSG DQIVLGKGIL NLIRALGGYT YAHSAETAFD TEDFNEHEYI
TEITRTSGNI EMVMNWWLVG YFCLGFIKEA CDLGFSIYET REMHPNHRHV RYALFFHTLA
MISRLRDNNL SEAEVIVYKK QIQTNKSFIL RWASPSPVNT TTWIALIDAE LSSLENSPDA
FRKYDKAVKL AVDYDWLLEE GWALYMQGSH FVRCGVEGLG TELQRRGIAR HRQWGARGIV
NYLTLTSTFS SQYSMKRSIF TASVAVQTES VVVGHGSHSQ PIYGPPTQMD TGEDHAANLS
AGDLAAILQW SKDLSRDINL SSALQRLTEI STETSGSLNT CVVITREVGD YTVATSMKAG
GPCLVHENAI SLRELDDPLQ VAILQHTLNS KERVYYEDAS TDPRFASEAT QTALRSVICL
PIFSNRGQTF GAVYLANSSP FSKNTLSIMT LLCQQASISI ANALLFRSVQ TATRENLKMI
AAQRDALEAA RRSREDALKA TKIKSNFLAS MSHELRTPFS SFYGLLDLLS GTNLDSGQRE
IVQTAKQSCE LLLKIIDSIL DYSKLEASVD CMELLLPMAV QKLDLSFNIE PDVPSWVFAD
YARIRQVLMN LIGNAVKFTA GGYVRVFCSV DTSATVAAGE VQLKFVIQDT GIGLSSSDVD
QLFVPFQQAD NSSTRKFGGT GLGLSISRQL VTLMGGAIGV QSEINVGSKF WFTIPVKLHK
DDVSQKAIAE LNELRAALRK GAFHVLVISP SEVTLALLNN MLSSAGCNVT LISSLREAKA
RLPIIGSAPV KLDFVLLDDQ SERHVDEFTG FMVDLNLPGL SATKLIHLYT PTANRTSSSV
FSASSDRVIR MTKPPRTARL LQLLAELKNL QPAASTQPRS DVSKALDDLS AAQRTLFGNV
LVAEDNIVSQ NLLVKQLEKY QLKVTATSNG EEAIAEWESH EPGYFSVALF DHHMPICDGV
EATKRLRILE NKRKSPVVLP IVALSADCQE STKKLCMSAG MNGFFSKPLK KPDLAALLSM
FGHPPYTL
//
