ID D8PS08_SCHCM Unreviewed; 438 AA.
AC D8PS08;
DT 05-OCT-2010, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2010, sequence version 1.
DT 24-JAN-2024, entry version 54.
DE RecName: Full=Enoyl reductase (ER) domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=SCHCODRAFT_47749 {ECO:0000313|EMBL:EFJ01836.1};
OS Schizophyllum commune (strain H4-8 / FGSC 9210) (Split gill fungus).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC Agaricomycetidae; Agaricales; Schizophyllaceae; Schizophyllum.
OX NCBI_TaxID=578458 {ECO:0000313|Proteomes:UP000007431};
RN [1] {ECO:0000313|EMBL:EFJ01836.1, ECO:0000313|Proteomes:UP000007431}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=H4-8 / FGSC 9210 {ECO:0000313|Proteomes:UP000007431};
RX PubMed=20622885; DOI=10.1038/nbt.1643;
RA Ohm R.A., de Jong J.F., Lugones L.G., Aerts A., Kothe E., Stajich J.E.,
RA de Vries R.P., Record E., Levasseur A., Baker S.E., Bartholomew K.A.,
RA Coutinho P.M., Erdmann S., Fowler T.J., Gathman A.C., Lombard V.,
RA Henrissat B., Knabe N., Kuees U., Lilly W.W., Lindquist E., Lucas S.,
RA Magnuson J.K., Piumi F., Raudaskoski M., Salamov A., Schmutz J.,
RA Schwarze F.W.M.R., vanKuyk P.A., Horton J.S., Grigoriev I.V.,
RA Woesten H.A.B.;
RT "Genome sequence of the model mushroom Schizophyllum commune.";
RL Nat. Biotechnol. 28:957-963(2010).
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947,
CC ECO:0000256|RuleBase:RU361277};
CC -!- SIMILARITY: Belongs to the zinc-containing alcohol dehydrogenase
CC family. {ECO:0000256|RuleBase:RU361277}.
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DR EMBL; GL377302; EFJ01836.1; -; Genomic_DNA.
DR RefSeq; XP_003036738.1; XM_003036692.1.
DR AlphaFoldDB; D8PS08; -.
DR STRING; 578458.D8PS08; -.
DR GeneID; 9588161; -.
DR KEGG; scm:SCHCO_02499736; -.
DR VEuPathDB; FungiDB:SCHCODRAFT_02499736; -.
DR eggNOG; KOG0024; Eukaryota.
DR HOGENOM; CLU_026673_11_3_1; -.
DR InParanoid; D8PS08; -.
DR OMA; AMYGHRD; -.
DR OrthoDB; 948431at2759; -.
DR Proteomes; UP000007431; Unassembled WGS sequence.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd08283; FDH_like_1; 1.
DR Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR013149; ADH-like_C.
DR InterPro; IPR013154; ADH-like_N.
DR InterPro; IPR002328; ADH_Zn_CS.
DR InterPro; IPR011032; GroES-like_sf.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR42813:SF1; DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G03930)-RELATED; 1.
DR PANTHER; PTHR42813; ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE; 1.
DR Pfam; PF08240; ADH_N; 1.
DR Pfam; PF00107; ADH_zinc_N; 1.
DR SUPFAM; SSF50129; GroES-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS00059; ADH_ZINC; 1.
PE 3: Inferred from homology;
KW Metal-binding {ECO:0000256|RuleBase:RU361277};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000007431};
KW Zinc {ECO:0000256|RuleBase:RU361277}.
FT DOMAIN 57..180
FT /note="Alcohol dehydrogenase-like N-terminal"
FT /evidence="ECO:0000259|Pfam:PF08240"
FT DOMAIN 226..292
FT /note="Alcohol dehydrogenase-like C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00107"
SQ SEQUENCE 438 AA; 48449 MW; C741E1FB7BBE2030 CRC64;
MQAAANAIQD HMGPIETEVK PEYKHDPTGK TMKALAWFGT NDLRLIDAPV PDITQDDDVI
LKVTGTTVCG SDNHLKNGEI VTLQKGDILG HEFMGKVWKV GPKVTKFKEG DRVVAAFQIP
CGHCEYCQKK LSSFCDNTNN SSLMNAMYGQ RDAGFFGYSH FTGGFPGGQA EYVRVPRAEV
ALLPIPDDVP DEQALYLSDI LPTSYHAVYD TGVEPGDVVG VWGMGPIGLC VAKWALLKGA
KRVIGIDKVA DRLAFAESRL GIETVNFTEY KDVPKRIYEL VPRGLDVAID CGTFHEPKTL
LHKVQKTLML ETDVPEIVNE MIVSVRKMGR CGVIAAYSGY ANGFAIGALM EKGIRFIGNG
QAPVLRYWET ILNDYIRTGK FDTSFVVTHR IPLDDIVPFY DIFNNRQADV EKVFIETQFS
SPPSKGFPAT TRVKDWVL
//
