ID D8PT04_SCHCM Unreviewed; 554 AA.
AC D8PT04;
DT 05-OCT-2010, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2010, sequence version 1.
DT 27-MAR-2024, entry version 52.
DE RecName: Full=Mannosyltransferase {ECO:0000256|RuleBase:RU363075};
DE EC=2.4.1.- {ECO:0000256|RuleBase:RU363075};
GN ORFNames=SCHCODRAFT_52228 {ECO:0000313|EMBL:EFJ01231.1};
OS Schizophyllum commune (strain H4-8 / FGSC 9210) (Split gill fungus).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC Agaricomycetidae; Agaricales; Schizophyllaceae; Schizophyllum.
OX NCBI_TaxID=578458 {ECO:0000313|Proteomes:UP000007431};
RN [1] {ECO:0000313|EMBL:EFJ01231.1, ECO:0000313|Proteomes:UP000007431}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=H4-8 / FGSC 9210 {ECO:0000313|Proteomes:UP000007431};
RX PubMed=20622885; DOI=10.1038/nbt.1643;
RA Ohm R.A., de Jong J.F., Lugones L.G., Aerts A., Kothe E., Stajich J.E.,
RA de Vries R.P., Record E., Levasseur A., Baker S.E., Bartholomew K.A.,
RA Coutinho P.M., Erdmann S., Fowler T.J., Gathman A.C., Lombard V.,
RA Henrissat B., Knabe N., Kuees U., Lilly W.W., Lindquist E., Lucas S.,
RA Magnuson J.K., Piumi F., Raudaskoski M., Salamov A., Schmutz J.,
RA Schwarze F.W.M.R., vanKuyk P.A., Horton J.S., Grigoriev I.V.,
RA Woesten H.A.B.;
RT "Genome sequence of the model mushroom Schizophyllum commune.";
RL Nat. Biotechnol. 28:957-963(2010).
CC -!- FUNCTION: Mannosyltransferase involved in glycosylphosphatidylinositol-
CC anchor biosynthesis. Transfers the third mannose to Man2-GlcN-acyl-PI
CC during GPI precursor assembly. {ECO:0000256|ARBA:ARBA00024708}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|RuleBase:RU363075}; Multi-pass membrane protein
CC {ECO:0000256|RuleBase:RU363075}.
CC -!- SIMILARITY: Belongs to the glycosyltransferase 22 family. PIGB
CC subfamily. {ECO:0000256|ARBA:ARBA00006065}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU363075}.
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DR EMBL; GL377303; EFJ01231.1; -; Genomic_DNA.
DR RefSeq; XP_003036133.1; XM_003036087.1.
DR AlphaFoldDB; D8PT04; -.
DR STRING; 578458.D8PT04; -.
DR GeneID; 9597142; -.
DR KEGG; scm:SCHCO_052228; -.
DR VEuPathDB; FungiDB:SCHCODRAFT_052228; -.
DR eggNOG; KOG1771; Eukaryota.
DR HOGENOM; CLU_012353_0_1_1; -.
DR InParanoid; D8PT04; -.
DR OMA; FNNYGYL; -.
DR OrthoDB; 37262at2759; -.
DR Proteomes; UP000007431; Unassembled WGS sequence.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016757; F:glycosyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0006506; P:GPI anchor biosynthetic process; IEA:UniProtKB-KW.
DR InterPro; IPR005599; GPI_mannosylTrfase.
DR PANTHER; PTHR22760; GLYCOSYLTRANSFERASE; 1.
DR PANTHER; PTHR22760:SF4; GPI MANNOSYLTRANSFERASE 3; 1.
DR Pfam; PF03901; Glyco_transf_22; 1.
PE 3: Inferred from homology;
KW Endoplasmic reticulum {ECO:0000256|RuleBase:RU363075};
KW Glycosyltransferase {ECO:0000256|RuleBase:RU363075};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU363075};
KW Reference proteome {ECO:0000313|Proteomes:UP000007431};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:EFJ01231.1};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU363075};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU363075}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..554
FT /note="Mannosyltransferase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003120240"
FT TRANSMEM 169..192
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363075"
FT TRANSMEM 204..224
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363075"
FT TRANSMEM 256..276
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363075"
FT TRANSMEM 358..375
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363075"
SQ SEQUENCE 554 AA; 61754 MW; 126B6A2B0BE12181 CRC64;
MLFLLAVTVR ILVALLTRTS FQPDEYFQAL EPAHDLVFGY GHLTWEWLTP NPIRSILYPL
LNVPVFWILK AAGLDSVNCL LIAGPRLVHG TLAALTDLFS YKLARRELGP SYANVALFLS
LTSPFNALAL SRSLSNSLET SLSTVAYVYY PWSETNRLLK YVFISRLRVV LALAALACLV
RPTNAVIWIY LFGQLFANQP NIRLHLTVNA IVTGIVALSI QILADSIYYG RLVITPLNFL
RANASSVSLF YGQNNATFYI FQALPVLCST ALPFALHGIY KSLRNTDSTN SALTQMTRAT
AWTMAVYSLA GHKEWRFIHP LLPLLHTLAA KSIVDLSTSS SPPSKSSKAR SRFPVKRAYL
ALLALGIPAS LYVVLIHNSA PISAVAYLHN LPASANATSV VGVLMPCHSL PGQAYLHRSD
FADLRVMWSL GCEPPLGLNP EAAESYMDQT TVFFDNPRQY LVDRFPTGVN ASFPPSPKPF
TPPTSAGDLS QDWRHEWPRY LVLYGALLHH EDVRVLLHQK GYREIWSSGE HWWQGSIGPD
EERMGGIRVW RWES
//
