ID D8Q7D6_SCHCM Unreviewed; 434 AA.
AC D8Q7D6;
DT 05-OCT-2010, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2010, sequence version 1.
DT 24-JAN-2024, entry version 51.
DE RecName: Full=Pre-mRNA-splicing factor PRP46 {ECO:0000256|RuleBase:RU369036};
DE AltName: Full=Pre-mRNA-processing protein 46 {ECO:0000256|RuleBase:RU369036};
GN ORFNames=SCHCODRAFT_68444 {ECO:0000313|EMBL:EFI96008.1};
OS Schizophyllum commune (strain H4-8 / FGSC 9210) (Split gill fungus).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC Agaricomycetidae; Agaricales; Schizophyllaceae; Schizophyllum.
OX NCBI_TaxID=578458 {ECO:0000313|Proteomes:UP000007431};
RN [1] {ECO:0000313|EMBL:EFI96008.1, ECO:0000313|Proteomes:UP000007431}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=H4-8 / FGSC 9210 {ECO:0000313|Proteomes:UP000007431};
RX PubMed=20622885; DOI=10.1038/nbt.1643;
RA Ohm R.A., de Jong J.F., Lugones L.G., Aerts A., Kothe E., Stajich J.E.,
RA de Vries R.P., Record E., Levasseur A., Baker S.E., Bartholomew K.A.,
RA Coutinho P.M., Erdmann S., Fowler T.J., Gathman A.C., Lombard V.,
RA Henrissat B., Knabe N., Kuees U., Lilly W.W., Lindquist E., Lucas S.,
RA Magnuson J.K., Piumi F., Raudaskoski M., Salamov A., Schmutz J.,
RA Schwarze F.W.M.R., vanKuyk P.A., Horton J.S., Grigoriev I.V.,
RA Woesten H.A.B.;
RT "Genome sequence of the model mushroom Schizophyllum commune.";
RL Nat. Biotechnol. 28:957-963(2010).
CC -!- FUNCTION: Involved in pre-mRNA splicing and required for cell cycle
CC progression at G2/M. {ECO:0000256|RuleBase:RU369036}.
CC -!- SUBUNIT: Associated with the spliceosome.
CC {ECO:0000256|RuleBase:RU369036}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU369036}.
CC -!- SIMILARITY: Belongs to the WD repeat PRL1/PRL2 family.
CC {ECO:0000256|ARBA:ARBA00025726, ECO:0000256|RuleBase:RU369036}.
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DR EMBL; GL377307; EFI96008.1; -; Genomic_DNA.
DR RefSeq; XP_003030911.1; XM_003030865.1.
DR AlphaFoldDB; D8Q7D6; -.
DR STRING; 578458.D8Q7D6; -.
DR GeneID; 9587429; -.
DR KEGG; scm:SCHCO_02629367; -.
DR VEuPathDB; FungiDB:SCHCODRAFT_02629367; -.
DR eggNOG; KOG0285; Eukaryota.
DR HOGENOM; CLU_000288_72_2_1; -.
DR InParanoid; D8Q7D6; -.
DR OMA; FAMCFDQ; -.
DR OrthoDB; 118158at2759; -.
DR Proteomes; UP000007431; Unassembled WGS sequence.
DR GO; GO:0005681; C:spliceosomal complex; IEA:UniProtKB-KW.
DR GO; GO:0000398; P:mRNA splicing, via spliceosome; IEA:UniProtKB-UniRule.
DR CDD; cd00200; WD40; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR InterPro; IPR045241; Prp46/PLRG1-like.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR19923:SF0; PLEIOTROPIC REGULATOR 1; 1.
DR PANTHER; PTHR19923; WD40 REPEAT PROTEINPRL1/PRL2-RELATED; 1.
DR Pfam; PF00400; WD40; 7.
DR PRINTS; PR00320; GPROTEINBRPT.
DR SMART; SM00320; WD40; 7.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 2.
DR PROSITE; PS50082; WD_REPEATS_2; 5.
DR PROSITE; PS50294; WD_REPEATS_REGION; 5.
PE 3: Inferred from homology;
KW mRNA processing {ECO:0000256|RuleBase:RU369036};
KW mRNA splicing {ECO:0000256|RuleBase:RU369036};
KW Nucleus {ECO:0000256|RuleBase:RU369036};
KW Reference proteome {ECO:0000313|Proteomes:UP000007431};
KW Repeat {ECO:0000256|ARBA:ARBA00022737, ECO:0000256|RuleBase:RU369036};
KW Spliceosome {ECO:0000256|RuleBase:RU369036};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT REPEAT 138..179
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 180..221
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 222..263
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 264..305
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 349..389
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
SQ SEQUENCE 434 AA; 47579 MW; 84363CABEBC532A6 CRC64;
MASVLPPLDG LHRRSVKRTR DIFASSIDEV VPDEERSTRI RLSVRINDEF RDFKELPAAL
ISQQGPVGPS RPKEQRKMIT AGPADNTSRM IATIDKTPIS QPTTFSSSSK LSQALTLHKT
TRTVKPTYHP PWKLVRVISG HLGWVRSVAV EPGNKWFATG AGDRVIKIWD LASGELKLSL
TGHISTVRGL AVSARHPYLF SCGEDKMVKC WDLESNKVIR HYHGHLSGVY ALDLHPTLDV
LVTSGRDASA RVWDMRTKAQ IHILSGHTGT VADVKCQESD PQVITGSMDT TVRLWDLAAG
KTMTTLTHHK KSVRALAIHP TEYSFASGSA GGNNIKKWKC PDGTFVFNFS GHNAIINTLS
VNAEGIFFSG GDNGSLTFWD YNTGTPFQNM EDVPQPGSLE AEAGVFCSTF DMTGTRLITG
GADKTIKIYA EQAH
//
