ID D8Q8H3_SCHCM Unreviewed; 640 AA.
AC D8Q8H3;
DT 05-OCT-2010, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2010, sequence version 1.
DT 27-MAR-2024, entry version 56.
DE RecName: Full=RhoGAP-domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=SCHCODRAFT_68756 {ECO:0000313|EMBL:EFI95065.1};
OS Schizophyllum commune (strain H4-8 / FGSC 9210) (Split gill fungus).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC Agaricomycetidae; Agaricales; Schizophyllaceae; Schizophyllum.
OX NCBI_TaxID=578458 {ECO:0000313|Proteomes:UP000007431};
RN [1] {ECO:0000313|EMBL:EFI95065.1, ECO:0000313|Proteomes:UP000007431}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=H4-8 / FGSC 9210 {ECO:0000313|Proteomes:UP000007431};
RX PubMed=20622885; DOI=10.1038/nbt.1643;
RA Ohm R.A., de Jong J.F., Lugones L.G., Aerts A., Kothe E., Stajich J.E.,
RA de Vries R.P., Record E., Levasseur A., Baker S.E., Bartholomew K.A.,
RA Coutinho P.M., Erdmann S., Fowler T.J., Gathman A.C., Lombard V.,
RA Henrissat B., Knabe N., Kuees U., Lilly W.W., Lindquist E., Lucas S.,
RA Magnuson J.K., Piumi F., Raudaskoski M., Salamov A., Schmutz J.,
RA Schwarze F.W.M.R., vanKuyk P.A., Horton J.S., Grigoriev I.V.,
RA Woesten H.A.B.;
RT "Genome sequence of the model mushroom Schizophyllum commune.";
RL Nat. Biotechnol. 28:957-963(2010).
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DR EMBL; GL377308; EFI95065.1; -; Genomic_DNA.
DR RefSeq; XP_003029968.1; XM_003029922.1.
DR AlphaFoldDB; D8Q8H3; -.
DR STRING; 578458.D8Q8H3; -.
DR GeneID; 9591389; -.
DR KEGG; scm:SCHCO_01156815; -.
DR VEuPathDB; FungiDB:SCHCODRAFT_01156815; -.
DR eggNOG; KOG1453; Eukaryota.
DR HOGENOM; CLU_017132_0_0_1; -.
DR InParanoid; D8Q8H3; -.
DR OMA; WGSQVRC; -.
DR OrthoDB; 5482027at2759; -.
DR Proteomes; UP000007431; Unassembled WGS sequence.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProt.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd00029; C1; 1.
DR CDD; cd00159; RhoGAP; 1.
DR Gene3D; 3.30.60.20; -; 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR046349; C1-like_sf.
DR InterPro; IPR002219; PE/DAG-bd.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR PANTHER; PTHR23176; RHO/RAC/CDC GTPASE-ACTIVATING PROTEIN; 1.
DR PANTHER; PTHR23176:SF141; TRANSDUCER, PUTATIVE-RELATED; 1.
DR Pfam; PF00130; C1_1; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00109; C1; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF57889; Cysteine-rich domain; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR PROSITE; PS50238; RHOGAP; 1.
DR PROSITE; PS00479; ZF_DAG_PE_1; 1.
DR PROSITE; PS50081; ZF_DAG_PE_2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000007431};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 369..416
FT /note="Phorbol-ester/DAG-type"
FT /evidence="ECO:0000259|PROSITE:PS50081"
FT DOMAIN 439..636
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 1..23
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 272..308
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 157..191
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 222..249
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 279..295
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 640 AA; 71637 MW; 1BAC1AC5AA86905D CRC64;
MPLRARAISE STAGRPSMER NVPPRIAVSQ TEGGVLRTEQ SEAIMQRLQD ALVDARGRGA
QDMKLDRAFV EAILTAWNSK SAEVNELRSK FDSEKRTSKQ YIDGLSVAQT EYDRELKARR
EAEAEVTRLR VLLSGQAARL TALSGDNRRQ EVRQKATREM DERLSGLQQD LSKLKVERDM
TLAEVEELNT AKSPTNPDPP ANLGRTLSMR LDNIKSQYQH DLVPLTQQRE ALQREIAELK
AVRDVFLEET TTLNARNEEL AQLSAQYTRK LEMAPETPQK QTMGRSASLR KKRPTTPQQA
PPPPAPPIIS GPMNPVILPP SASDDNQNAI RVVRLDADLT PNKAKWFRPK AKEAPVPTPD
GKGTKGIQEH NFQQLSILRF TRCDHCGDKM WGSQLRCTVC NVAVHVRCLN LVQTSCGQQH
GSGNRDESHG PLPPSMFGRD LVEQVQADAA KAGQERQVPV IVEKCIDAVE ASALDYEGIY
RKTGGSNQSK AITQLFERGD YLSFDLRDSD RFNDICSVTS VLKSYFRSLP NPLLTFELHE
QFMSAVEIKD IPTKNKALLD LVNSLPPPHY YTLRVLMLHL HRIFERAERN LMNARNLGVV
FGPTLMRSSN PGAEFSDMAG KALTIEWLVE NAPFVFKVSS
//
