ID D8QCJ5_SCHCM Unreviewed; 562 AA.
AC D8QCJ5;
DT 05-OCT-2010, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2010, sequence version 1.
DT 27-MAR-2024, entry version 61.
DE RecName: Full=Vacuolar protein-sorting-associated protein 36 {ECO:0000256|RuleBase:RU367095};
DE AltName: Full=ESCRT-II complex subunit VPS36 {ECO:0000256|RuleBase:RU367095};
DE Flags: Fragment;
GN ORFNames=SCHCODRAFT_111589 {ECO:0000313|EMBL:EFI94942.1};
OS Schizophyllum commune (strain H4-8 / FGSC 9210) (Split gill fungus).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC Agaricomycetidae; Agaricales; Schizophyllaceae; Schizophyllum.
OX NCBI_TaxID=578458 {ECO:0000313|Proteomes:UP000007431};
RN [1] {ECO:0000313|EMBL:EFI94942.1, ECO:0000313|Proteomes:UP000007431}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=H4-8 / FGSC 9210 {ECO:0000313|Proteomes:UP000007431};
RX PubMed=20622885; DOI=10.1038/nbt.1643;
RA Ohm R.A., de Jong J.F., Lugones L.G., Aerts A., Kothe E., Stajich J.E.,
RA de Vries R.P., Record E., Levasseur A., Baker S.E., Bartholomew K.A.,
RA Coutinho P.M., Erdmann S., Fowler T.J., Gathman A.C., Lombard V.,
RA Henrissat B., Knabe N., Kuees U., Lilly W.W., Lindquist E., Lucas S.,
RA Magnuson J.K., Piumi F., Raudaskoski M., Salamov A., Schmutz J.,
RA Schwarze F.W.M.R., vanKuyk P.A., Horton J.S., Grigoriev I.V.,
RA Woesten H.A.B.;
RT "Genome sequence of the model mushroom Schizophyllum commune.";
RL Nat. Biotechnol. 28:957-963(2010).
CC -!- FUNCTION: Component of the ESCRT-II complex (endosomal sorting complex
CC required for transport II), which is required for multivesicular body
CC (MVB) formation and sorting of endosomal cargo proteins into MVBs.
CC {ECO:0000256|RuleBase:RU367095}.
CC -!- SUBUNIT: Component of the endosomal sorting complex required for
CC transport II (ESCRT-II). {ECO:0000256|RuleBase:RU367095}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|RuleBase:RU367095}.
CC Endosome {ECO:0000256|RuleBase:RU367095}.
CC -!- SIMILARITY: Belongs to the VPS36 family.
CC {ECO:0000256|ARBA:ARBA00009697, ECO:0000256|RuleBase:RU367095}.
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DR EMBL; GL377309; EFI94942.1; -; Genomic_DNA.
DR RefSeq; XP_003029845.1; XM_003029799.1.
DR AlphaFoldDB; D8QCJ5; -.
DR STRING; 578458.D8QCJ5; -.
DR GeneID; 9591265; -.
DR KEGG; scm:SCHCO_02549916; -.
DR VEuPathDB; FungiDB:SCHCODRAFT_02549916; -.
DR eggNOG; KOG2760; Eukaryota.
DR HOGENOM; CLU_015433_3_0_1; -.
DR InParanoid; D8QCJ5; -.
DR OMA; RVCYVDH; -.
DR OrthoDB; 1423843at2759; -.
DR Proteomes; UP000007431; Unassembled WGS sequence.
DR GO; GO:0000814; C:ESCRT II complex; IEA:UniProtKB-UniRule.
DR GO; GO:0031902; C:late endosome membrane; IEA:UniProtKB-UniRule.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0032266; F:phosphatidylinositol-3-phosphate binding; IEA:UniProtKB-UniRule.
DR GO; GO:0043130; F:ubiquitin binding; IEA:UniProtKB-UniRule.
DR GO; GO:0043328; P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway; IEA:UniProtKB-UniRule.
DR Gene3D; 6.10.140.260; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR Gene3D; 2.30.30.380; Zn-finger domain of Sec23/24; 1.
DR InterPro; IPR021648; GLUE_dom.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR040608; Snf8/Vps36.
DR InterPro; IPR037855; Vps36.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR InterPro; IPR001876; Znf_RanBP2.
DR PANTHER; PTHR13128; VACUOLAR PROTEIN-SORTING-ASSOCIATED PROTEIN 36; 1.
DR PANTHER; PTHR13128:SF12; VACUOLAR PROTEIN-SORTING-ASSOCIATED PROTEIN 36; 1.
DR Pfam; PF04157; EAP30; 1.
DR Pfam; PF11605; Vps36_ESCRT-II; 1.
DR SMART; SM00547; ZnF_RBZ; 2.
DR SUPFAM; SSF50729; PH domain-like; 2.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS51495; GLUE; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|RuleBase:RU367095};
KW Endosome {ECO:0000256|RuleBase:RU367095};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Protein transport {ECO:0000256|RuleBase:RU367095};
KW Reference proteome {ECO:0000313|Proteomes:UP000007431};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU367095}.
FT DOMAIN 10..250
FT /note="GLUE N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51495"
FT REGION 194..215
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 562
FT /evidence="ECO:0000313|EMBL:EFI94942.1"
SQ SEQUENCE 562 AA; 60428 MW; 9FFCCEF56A749343 CRC64;
MGLARRSKPI DGTIPVVALL YSDEELNASQ DGVGIYDGPI KSPDHQSGVI HLTSHRLIFV
SDTQPEKFSF SIDLADIRQT EYYAGLFTSS AKVTLVFDNA QAAASRTSVE DDDWGGWTCH
VCDNRNPPGT KSRLCALCGV PKSVDSSPRT TTPVPAVASP ALATRSKSCP ACTFINHPSM
RECEICGTPL PSASSSTPAP SLPSAPPPTT SAPDSNIVKI SFRKSGDKPF YAALKRALTA
KRWDVTRMPS GAVPPLRENQ SGINSLLNTL AETSSSRTTH LQAALGDLEA LRLRANDMVR
VATEVSERLK SANAPPVDTT GLALPDNSIG SAPTTEAESE LISSLSSLAL TTLKATPVTQ
DMIKDEEKWM QELARELASV LQGDNSSQRG GLMKARGIIA LDEVWGTWNR ARGVALLPPS
TLLSTVPLLP AHTNPKIRSR QFASGLKVLH TPHYSTPSFK TRLDDYLWEL GDGEAVSDPD
REAEAEESLP RPRAMTVTEI AAKEQVTIAL TQGMIEEIEA EGGILRDDVS SCALTAGQGI
GWGAEVRWWP NVVLLYSWDG HE
//
