ID D8QE33_SCHCM Unreviewed; 467 AA.
AC D8QE33;
DT 05-OCT-2010, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2010, sequence version 1.
DT 24-JAN-2024, entry version 55.
DE RecName: Full=L-fuconate dehydratase {ECO:0000256|ARBA:ARBA00013142};
DE EC=4.2.1.68 {ECO:0000256|ARBA:ARBA00013142};
GN ORFNames=SCHCODRAFT_17150 {ECO:0000313|EMBL:EFI93786.1};
OS Schizophyllum commune (strain H4-8 / FGSC 9210) (Split gill fungus).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC Agaricomycetidae; Agaricales; Schizophyllaceae; Schizophyllum.
OX NCBI_TaxID=578458 {ECO:0000313|Proteomes:UP000007431};
RN [1] {ECO:0000313|EMBL:EFI93786.1, ECO:0000313|Proteomes:UP000007431}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=H4-8 / FGSC 9210 {ECO:0000313|Proteomes:UP000007431};
RX PubMed=20622885; DOI=10.1038/nbt.1643;
RA Ohm R.A., de Jong J.F., Lugones L.G., Aerts A., Kothe E., Stajich J.E.,
RA de Vries R.P., Record E., Levasseur A., Baker S.E., Bartholomew K.A.,
RA Coutinho P.M., Erdmann S., Fowler T.J., Gathman A.C., Lombard V.,
RA Henrissat B., Knabe N., Kuees U., Lilly W.W., Lindquist E., Lucas S.,
RA Magnuson J.K., Piumi F., Raudaskoski M., Salamov A., Schmutz J.,
RA Schwarze F.W.M.R., vanKuyk P.A., Horton J.S., Grigoriev I.V.,
RA Woesten H.A.B.;
RT "Genome sequence of the model mushroom Schizophyllum commune.";
RL Nat. Biotechnol. 28:957-963(2010).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-fuconate = 2-dehydro-3-deoxy-L-fuconate + H2O;
CC Xref=Rhea:RHEA:22772, ChEBI:CHEBI:15377, ChEBI:CHEBI:21291,
CC ChEBI:CHEBI:37448; EC=4.2.1.68;
CC Evidence={ECO:0000256|ARBA:ARBA00001737};
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
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DR EMBL; GL377310; EFI93786.1; -; Genomic_DNA.
DR RefSeq; XP_003028689.1; XM_003028643.1.
DR AlphaFoldDB; D8QE33; -.
DR STRING; 578458.D8QE33; -.
DR GeneID; 9591099; -.
DR KEGG; scm:SCHCO_02513503; -.
DR VEuPathDB; FungiDB:SCHCODRAFT_02513503; -.
DR eggNOG; ENOG502QU7C; Eukaryota.
DR HOGENOM; CLU_030273_2_0_1; -.
DR InParanoid; D8QE33; -.
DR OMA; SGAIDVC; -.
DR OrthoDB; 2903547at2759; -.
DR Proteomes; UP000007431; Unassembled WGS sequence.
DR GO; GO:0050023; F:L-fuconate dehydratase activity; IEA:UniProtKB-EC.
DR GO; GO:0009063; P:amino acid catabolic process; IEA:InterPro.
DR GO; GO:0016052; P:carbohydrate catabolic process; IEA:InterPro.
DR CDD; cd03324; rTSbeta_L-fuconate_dehydratase; 1.
DR Gene3D; 3.20.20.120; Enolase-like C-terminal domain; 1.
DR Gene3D; 3.30.390.10; Enolase-like, N-terminal domain; 1.
DR InterPro; IPR036849; Enolase-like_C_sf.
DR InterPro; IPR029017; Enolase-like_N.
DR InterPro; IPR029065; Enolase_C-like.
DR InterPro; IPR034610; L-fuconate_dehydratase.
DR InterPro; IPR018110; Mandel_Rmase/mucon_lact_enz_CS.
DR InterPro; IPR013342; Mandelate_racemase_C.
DR InterPro; IPR013341; Mandelate_racemase_N_dom.
DR InterPro; IPR046945; RHMD-like.
DR PANTHER; PTHR13794; ENOLASE SUPERFAMILY, MANDELATE RACEMASE; 1.
DR PANTHER; PTHR13794:SF58; MITOCHONDRIAL ENOLASE SUPERFAMILY MEMBER 1; 1.
DR Pfam; PF13378; MR_MLE_C; 1.
DR Pfam; PF02746; MR_MLE_N; 1.
DR SFLD; SFLDS00001; Enolase; 1.
DR SMART; SM00922; MR_MLE; 1.
DR SUPFAM; SSF51604; Enolase C-terminal domain-like; 1.
DR SUPFAM; SSF54826; Enolase N-terminal domain-like; 1.
DR PROSITE; PS00909; MR_MLE_2; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000007431}.
FT DOMAIN 197..318
FT /note="Mandelate racemase/muconate lactonizing enzyme C-
FT terminal"
FT /evidence="ECO:0000259|SMART:SM00922"
FT REGION 238..260
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 467 AA; 51411 MW; B1CF1C74C5B3E55F CRC64;
MPKITGYETH DVRFPTSLSG DGTDAMNTDC DYSSAYVEIK TDSDLVGYGM TFTIGRGNDI
VCMAIGHVVS RLIGKDTEEL FANMGKTWDY LTADPQLRWI GPEKGVIHIA TGAVNNAVWD
MYARSRNKPL WKLVVDFTPE ELVASAAWRY ISDAITKEEA LAMLKEREAG KKEREATVRE
LGYPAYVTSA GWLGYDDEKI ARLTKEAVAQ GFNHFKMKVG ADPASDLRRG KIIRSIIDDP
QYLPPGGGRD PNSKELQGKN AGPTGAVFMI DANQVWDVPQ AIEYVKGLAE IKPWFIEEPT
APDDILGHAA IRKALKPHGI GVATGEHAHN RMVFKQLLQA EAIDVVQIDS CRLAGVSEVI
SVLLMAAKFG VPVCPHAGGV GLCEYVIHLS LIDYIAVSGN MDRNVLEFVD HLHEHFVTPC
SINPKGRYNV PSNPKEGYSI EMKKDSIAEY EWPNGSYWVG ARGGKKL
//
