ID D8TJX6_VOLCA Unreviewed; 1051 AA.
AC D8TJX6;
DT 05-OCT-2010, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2010, sequence version 1.
DT 27-MAR-2024, entry version 49.
DE RecName: Full=Apyrase {ECO:0008006|Google:ProtNLM};
GN ORFNames=VOLCADRAFT_120373 {ECO:0000313|EMBL:EFJ51965.1};
OS Volvox carteri f. nagariensis.
OC Eukaryota; Viridiplantae; Chlorophyta; core chlorophytes; Chlorophyceae;
OC CS clade; Chlamydomonadales; Volvocaceae; Volvox.
OX NCBI_TaxID=3068 {ECO:0000313|Proteomes:UP000001058};
RN [1] {ECO:0000313|EMBL:EFJ51965.1, ECO:0000313|Proteomes:UP000001058}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=f. Nagariensis / Eve {ECO:0000313|Proteomes:UP000001058};
RX PubMed=20616280; DOI=10.1126/science.1188800;
RA Prochnik S.E., Umen J., Nedelcu A.M., Hallmann A., Miller S.M., Nishii I.,
RA Ferris P., Kuo A., Mitros T., Fritz-Laylin L.K., Hellsten U., Chapman J.,
RA Simakov O., Rensing S.A., Terry A., Pangilinan J., Kapitonov V., Jurka J.,
RA Salamov A., Shapiro H., Schmutz J., Grimwood J., Lindquist E., Lucas S.,
RA Grigoriev I.V., Schmitt R., Kirk D., Rokhsar D.S.;
RT "Genomic analysis of organismal complexity in the multicellular green alga
RT Volvox carteri.";
RL Science 329:223-226(2010).
CC -!- SIMILARITY: Belongs to the GDA1/CD39 NTPase family.
CC {ECO:0000256|ARBA:ARBA00009283, ECO:0000256|RuleBase:RU003833}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; GL378325; EFJ51965.1; -; Genomic_DNA.
DR RefSeq; XP_002946739.1; XM_002946693.1.
DR AlphaFoldDB; D8TJX6; -.
DR STRING; 3068.D8TJX6; -.
DR GeneID; 9624644; -.
DR KEGG; vcn:VOLCADRAFT_120373; -.
DR eggNOG; KOG1386; Eukaryota.
DR InParanoid; D8TJX6; -.
DR OrthoDB; 180318at2759; -.
DR Proteomes; UP000001058; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR Gene3D; 3.30.420.40; -; 2.
DR Gene3D; 3.30.420.150; Exopolyphosphatase. Domain 2; 2.
DR InterPro; IPR013730; Fyv7/TAP26.
DR InterPro; IPR000407; GDA1_CD39_NTPase.
DR PANTHER; PTHR11782; ADENOSINE/GUANOSINE DIPHOSPHATASE; 1.
DR PANTHER; PTHR11782:SF3; APYRASE 6-RELATED; 1.
DR Pfam; PF01150; GDA1_CD39; 2.
DR Pfam; PF08524; rRNA_processing; 1.
DR PROSITE; PS01238; GDA1_CD39_NTPASE; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|PIRSR:PIRSR600407-2};
KW Hydrolase {ECO:0000256|RuleBase:RU003833};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|PIRSR:PIRSR600407-2};
KW Reference proteome {ECO:0000313|Proteomes:UP000001058};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 52..72
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 585..606
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 367..413
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 825..1007
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1014..1033
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 911..925
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 959..1007
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 212
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR600407-1"
FT BINDING 256..260
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PIRSR:PIRSR600407-2"
SQ SEQUENCE 1051 AA; 111659 MW; 9681210A644F883F CRC64;
MHKSRSSVKI SIWSDGDAAA KGSIVKTVKL VNRYLQRLRL AEQWPMGNRR GWLLLCLAAT
GGLALLILLR AASFIGEGLV QQAQGDQYAV YIDGGSSGTR VRVFRYRPAR WPAYVVLVLP
EPSRSVEPGL SAYANQPDRA AASLVPLLDF AYEQVPMELW HQTPVRLLAT AGLRLLDQQE
QEAILGSCQQ LLAASRFRFE PSWATVIDGE MEGLFGWAAV NYLTGALQEA SAHSHHSRKE
VMDPAQLFTG LLEMGGASVQ VTFLPPVTAK QAERHGSHLH LPGVPSRLFT HSYLGLGMDS
ALAQAAEYVL RHQPRSPAIS DPCLPIGYVS EDGRIGNGSF AQCMAVVQRI MPEHDCFPSQ
SAAAAVGSSG GRAEASETGR KITEEGENAA SGGYDDDPAV DAHSSSRAGG GSVASVAGEG
GGCVLQGSFL PVLSGRFVAV ENFAWTARAL GLHENATLRQ LRESGHHYCA KHWSSLHAEF
SGHIPDQFLV RYCFGAAYIL ALLHSGFGLG LDDGRLWWTN TVREAGEGAE VGLNWVLGAA
VVDAMSSSGG VGGGEEHNRG GAAGSQRFWL RDEQGMAAAT GSARMVLMLP LAALAALAAF
VGLALLRILR SGKARIVTLT PGSGGGAGAL FSSRGFGAGS EERARTGGGG RAAGVATSWS
STSLVSEVAA GRSLPGITVR DASSLDPGLG QSPGADVGQR GQGFWYAGMG QGAGASHEGG
VAGVKHGGVL KAAALLGSAM RRNPSFTSVL IGVEGLSLDK FAKLGVSQFD KRKKLERIKK
QKIIEYSKYK KLKHKLEAQG VLSGAPVKDS VAELEALDFD APLKSAAGSA DEPASHEERI
VSHTRAGPSS RPRHGSEPKA QTPAIPDAAE VPGARGPSCG GQRKTEQPGA GVRKRARVDD
SVAAQFKQPS RHKGPDSKCA DWNAVPDEDG DAMVEYAARS GDKQPAGASA AHRGEQGQVS
ERQGSREGDN RGVKKLSRLQ RLAQRVAEEK AEKQRAKETA MKEREERLKH VAAAEKSRKE
QKHLHFKRNA KGQPLMRYRM EKLLSQIQKT V
//
