ID D9MNM1_9VIRU Unreviewed; 312 AA.
AC D9MNM1;
DT 05-OCT-2010, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2010, sequence version 1.
DT 24-JAN-2024, entry version 26.
DE SubName: Full=ORF1a {ECO:0000313|EMBL:ADJ38389.1};
DE Flags: Fragment;
GN Name=ORF1a {ECO:0000313|EMBL:ADJ38389.1};
OS Astrovirus rat/RS118/HKG/2007.
OC Viruses; Riboviria; Orthornavirae; Pisuviricota; Stelpaviricetes;
OC Stellavirales; Astroviridae.
OX NCBI_TaxID=858506 {ECO:0000313|EMBL:ADJ38389.1};
RN [1] {ECO:0000313|EMBL:ADJ38389.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=RS118 {ECO:0000313|EMBL:ADJ38389.1};
RX PubMed=20554799; DOI=10.1099/vir.0.022764-0;
RA Chu D.K., Chin A.W., Smith G.J., Chan K.H., Guan Y., Peiris J.S.,
RA Poon L.L.;
RT "Detection of novel astroviruses in urban brown rats and previously known
RT astroviruses in humans.";
RL J. Gen. Virol. 91:2457-2462(2010).
RN [2] {ECO:0000313|EMBL:ADJ38389.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=RS118 {ECO:0000313|EMBL:ADJ38389.1};
RA Chu D.K.W., Chin A.W.H., Smith G.J., Chan K.H., Guan Y., Peiris J.S.,
RA Poon L.L.M.;
RL Submitted (JUN-2010) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Protein covalently attached to the 5' extremity of the
CC genomic and subgenomic RNAs. {ECO:0000256|ARBA:ARBA00029406}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate +
CC RNA(n+1); Xref=Rhea:RHEA:21248, Rhea:RHEA-COMP:14527, Rhea:RHEA-
CC COMP:17342, ChEBI:CHEBI:33019, ChEBI:CHEBI:61557, ChEBI:CHEBI:140395;
CC Evidence={ECO:0000256|ARBA:ARBA00024586};
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DR EMBL; HM450381; ADJ38389.1; -; Genomic_RNA.
DR MEROPS; S01.109; -.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR Gene3D; 2.40.10.10; Trypsin-like serine proteases; 1.
DR InterPro; IPR045836; Astro_VPg.
DR InterPro; IPR009003; Peptidase_S1_PA.
DR InterPro; IPR043504; Peptidase_S1_PA_chymotrypsin.
DR Pfam; PF19416; Astro_VPg; 1.
DR Pfam; PF13365; Trypsin_2; 1.
DR SUPFAM; SSF50494; Trypsin-like serine proteases; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801}.
FT REGION 185..211
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 248..312
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 252..270
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ADJ38389.1"
SQ SEQUENCE 312 AA; 35182 MW; FF1C096DF537790F CRC64;
HTYQTEVVRH VTGKDIVLLK IPPQCVAVPR YKVAKEPCYD WVCVLAPDGN GAYITSVTNG
FGHGDTISYA TPTRDGMSGA PVVDQNGHVV GVHQTNTGFT GGAQVLVLTD IEMPSKQQIE
VNELKAEIER LKAMLPPEKE KEEIVESSAL DQCMNDVDIV HLVRAAVGRE VAVLREELAF
EQAKGKTKHG RGFRHNPRTF NRPVPVKGGK RKRKVFTEQE YKELLEAGLD ADKIRELVDE
ILTREAEEVG YPEWSDPDED QDEELEDEWF GRYNENEKEQ VPENTDAEQP QQQQQSKNER
RGRRRGPKNG TN
//
