ID D9N3B9_ALLMI Unreviewed; 677 AA.
AC D9N3B9;
DT 05-OCT-2010, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2010, sequence version 1.
DT 24-JAN-2024, entry version 53.
DE RecName: Full=Muellerian-inhibiting factor {ECO:0000256|ARBA:ARBA00020473};
DE AltName: Full=Anti-Muellerian hormone {ECO:0000256|ARBA:ARBA00030008};
DE AltName: Full=Muellerian-inhibiting substance {ECO:0000256|ARBA:ARBA00031273};
GN Name=amAMH {ECO:0000313|EMBL:BAJ14757.1};
OS Alligator mississippiensis (American alligator).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC Alligator.
OX NCBI_TaxID=8496 {ECO:0000313|EMBL:BAJ14757.1};
RN [1] {ECO:0000313|EMBL:BAJ14757.1}
RP NUCLEOTIDE SEQUENCE.
RA Urushitani H., Katsu Y., Miyagawa S., Kohno S., Ohta Y., Guillette L.,
RA Iguchi T.;
RT "Molecular Cloning of Anti-Mullerian Hormone from the American Alligator,
RT Alligator mississippiensis.";
RL Submitted (FEB-2010) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBUNIT: Homodimer; disulfide-linked. {ECO:0000256|ARBA:ARBA00011748}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the TGF-beta family.
CC {ECO:0000256|ARBA:ARBA00006656, ECO:0000256|RuleBase:RU000354}.
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DR EMBL; AB546781; BAJ14757.1; -; mRNA.
DR EMBL; AB546782; BAJ14759.1; -; Genomic_DNA.
DR RefSeq; NP_001274209.1; NM_001287280.1.
DR AlphaFoldDB; D9N3B9; -.
DR GeneID; 102568833; -.
DR KEGG; amj:102568833; -.
DR CTD; 268; -.
DR OrthoDB; 3972567at2759; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007506; P:gonadal mesoderm development; IEA:UniProtKB-KW.
DR CDD; cd13757; TGF_beta_AMH; 1.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR006799; AMH_N.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR021203; Muellerian-inhibiting_factor.
DR InterPro; IPR001839; TGF-b_C.
DR InterPro; IPR017948; TGFb_CS.
DR PANTHER; PTHR15009; MUELLERIAN-INHIBITING FACTOR; 1.
DR PANTHER; PTHR15009:SF4; MUELLERIAN-INHIBITING FACTOR; 1.
DR Pfam; PF04709; AMH_N; 1.
DR Pfam; PF00019; TGF_beta; 1.
DR SMART; SM00204; TGFB; 1.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR PROSITE; PS00250; TGF_BETA_1; 1.
DR PROSITE; PS51362; TGF_BETA_2; 1.
PE 2: Evidence at transcript level;
KW Differentiation {ECO:0000256|ARBA:ARBA00023156};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Gonadal differentiation {ECO:0000256|ARBA:ARBA00023156};
KW Growth factor {ECO:0000256|ARBA:ARBA00023030,
KW ECO:0000256|RuleBase:RU000354}; Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..677
FT /note="Muellerian-inhibiting factor"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5007652671"
FT DOMAIN 562..677
FT /note="TGF-beta family profile"
FT /evidence="ECO:0000259|PROSITE:PS51362"
FT REGION 364..395
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 677 AA; 74757 MW; AC52191F39499007 CRC64;
MGPVLRVVLQ CLLLLFPSTA LPRIGSFGEG LSPAELQSTV ARELGLGEEE NMSSHAGAGN
FIASKGRATV APHLLLKAGE PRGDSKVVKH NQLITEDQGV FSYLQPNASL HPWLLGGLEG
PVCRLKMDRK DGLGQSHLEV MGVLTSYESD FIKLVRHAGW EEAPLETFGL CSAGDTSAAL
LSLKHISAHL SEPGENQFLV LHLEEVMWGT ETQLRFKLPF QEDMGWSLGQ LQFAVLVFYP
GSREREGIKA REMLQAEGKG LDRKQTLCLS RDTRYLVLGA LVTSVIHTHS QLSFEVSLVV
KHLGDGGPPL PPPEVQQLLF GSDEKCFTRM TPVVLLLAKS QHEEDVLHPS RFLSVAGVVE
TVPYPQPSSA PAGRAEEPPP DSATGQASTS TLAPGSTDQF LGSLTRFVSG ILGSSGEPLP
ASRVHHWLDV ETAETLPHQQ LNLSEEAALE QLVQSEEPLL LLFPHNSQAL LEQHFRHWRV
EGRVLQLLLE KLQAVIQDLR EIPAFQANAG LFQHLLAFCY YPPGPGSSDS LVTPLPEELR
GPRQLHTLLL LKALQTVRSH WRERRKVLWQ NRSARHQASC RLRELTVDIS HYKFIAVPDM
YVANNCEGPC RLPLSTRADY YPHTVLLLDM QERGVPLQRG PCCVPVQYSD QTIITLSDEG
PQVKMFHNMV AKACGCR
//
