ID D9X0F4_STRVT Unreviewed; 709 AA.
AC D9X0F4;
DT 05-OCT-2010, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2010, sequence version 1.
DT 27-MAR-2024, entry version 56.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN ORFNames=SSQG_06056 {ECO:0000313|EMBL:EFL35538.1};
OS Streptomyces viridochromogenes (strain DSM 40736 / JCM 4977 / BCRC 1201 /
OS Tue 494).
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=591159 {ECO:0000313|EMBL:EFL35538.1, ECO:0000313|Proteomes:UP000004184};
RN [1] {ECO:0000313|Proteomes:UP000004184}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 40736 / JCM 4977 / BCRC 1201 / Tue 494
RC {ECO:0000313|Proteomes:UP000004184};
RG The Broad Institute Genome Sequencing Platform;
RG Broad Institute Microbial Sequencing Center;
RA Fischbach M., Godfrey P., Ward D., Young S., Zeng Q., Koehrsen M.,
RA Alvarado L., Berlin A.M., Bochicchio J., Borenstein D., Chapman S.B.,
RA Chen Z., Engels R., Freedman E., Gellesch M., Goldberg J., Griggs A.,
RA Gujja S., Heilman E.R., Heiman D.I., Hepburn T.A., Howarth C., Jen D.,
RA Larson L., Lewis B., Mehta T., Park D., Pearson M., Richards J.,
RA Roberts A., Saif S., Shea T.D., Shenoy N., Sisk P., Stolte C., Sykes S.N.,
RA Thomson T., Walk T., White J., Yandava C., Straight P., Clardy J., Hung D.,
RA Kolter R., Mekalanos J., Walker S., Walsh C.T., Wieland-Brown L.C.,
RA Haas B., Nusbaum C., Birren B.;
RT "Annotation of Streptomyces viridochromogenes strain DSM 40736.";
RL Submitted (FEB-2009) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
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DR EMBL; GG657757; EFL35538.1; -; Genomic_DNA.
DR AlphaFoldDB; D9X0F4; -.
DR STRING; 591159.SSQG_06056; -.
DR eggNOG; COG0210; Bacteria.
DR HOGENOM; CLU_023846_0_0_11; -.
DR Proteomes; UP000004184; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 3.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR PANTHER; PTHR11070:SF2; ATP-DEPENDENT DNA HELICASE SRS2; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR Pfam; PF13361; UvrD_C; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Reference proteome {ECO:0000313|Proteomes:UP000004184}.
FT DOMAIN 252..523
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT BINDING 273..280
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 709 AA; 78255 MW; BBB5A0FD5A99C681 CRC64;
MMPRLAFAQS FWDGYDTLEK PVRAGVRKAM AKFQALSVAE LNADKGLHLE SVENARDKRM
RTIRITGFWR GVVLAPDDGS DTFLLVNVLP HDDAYTWAAK RLYSANSATR ALEVRDAVAL
DELTPLYETA ARTAPRLLFS DVSDGTLREL GIDEQVLRAA RSLVDKAQLE AFSTLLPEDQ
LEVLQYLAEG FSPEDVYRDV VAVRRPADAP AEPVEDLATV IANTPARIRL VTGPRELEEI
LEKPFEAWRV FLHPSQRRVA YRTSYGGPVQ VTGGPGTGKT VAALHRVKHL LGRSGDGRIL
LTTYTNALAA GLRDMLGLLL DEDEKLLARV DVTTVDACAH GIMRTRSAAV PKPIGDREQR
QLWEKAARQL DLPFTAQFLA QEYRHVVLGQ NLRDLDAYLG ASRRGRGTGL GPTRRRMVWS
GVQRFEQFLR DRGETTHLRV CARAAELLGE EPAPYAHVVV DEAQDLHPAQ WRVLRAAVAP
GPDDLFATGD PHQRIYDSRV SLGSLGIMTV GRSFRLRLNY RSTEEILAWS ARLLAPITVD
ALEGEGTDSL AGYRSLLHGR HPQAQGYATR QEETEALVER VRTLLAEGLA PHEIGVCARF
NLSLDTAEEK LKAAGIPVLR VRGQVAQGAE GVRLATMHAM KGLEFRAVSV LGVAEGTVPF
AREITPREAD PLQHDADLLR ERCLLFVACT RAREALSVTW SGAASPFLP
//
