ID D9YL70_9NEOB Unreviewed; 225 AA.
AC D9YL70;
DT 05-OCT-2010, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2010, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE SubName: Full=Chemokine receptor 4 {ECO:0000313|EMBL:ADK91205.1};
DE Flags: Fragment;
GN Name=CXCR4 {ECO:0000313|EMBL:ADK91205.1};
OS Phasmahyla exilis (mottled leaf frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Neobatrachia; Hyloidea; Hylidae; Phyllomedusinae;
OC Phasmahyla.
OX NCBI_TaxID=860361 {ECO:0000313|EMBL:ADK91205.1};
RN [1] {ECO:0000313|EMBL:ADK91205.1}
RP NUCLEOTIDE SEQUENCE.
RX AGRICOLA=IND44362043; DOI=10.1111/j.1096-0031.2009.00287.x;
RA Faivovich J., Haddad C.F.B., Baeta D., Jungfer K.-H., Alvares G.F.R.,
RA Brandao R.A., Sheil C., Barrientos L.S., Barrio-Amoros C.L., Cruz C.A.G.,
RA Wheeler W.C.;
RT "The phylogenetic relationships of the charismatic poster frogs,
RT Phyllomedusinae (Anura, Hylidae).";
RL Cladistics 26:227-261(2010).
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000256|RuleBase:RU000688}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; GQ365997; ADK91205.1; -; Genomic_DNA.
DR AlphaFoldDB; D9YL70; -.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR001277; CXCR4/ACKR2.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR PANTHER; PTHR10489:SF594; C-X-C CHEMOKINE RECEPTOR TYPE 4; 1.
DR PANTHER; PTHR10489; CELL ADHESION MOLECULE; 1.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00645; CXCCHMKINER4.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW G-protein coupled receptor {ECO:0000256|RuleBase:RU000688};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|RuleBase:RU000688, ECO:0000313|EMBL:ADK91205.1};
KW Transducer {ECO:0000256|RuleBase:RU000688};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU000688};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..36
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 48..68
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 88..109
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 129..157
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 178..205
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..225
FT /note="G-protein coupled receptors family 1 profile"
FT /evidence="ECO:0000259|PROSITE:PS50262"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ADK91205.1"
FT NON_TER 225
FT /evidence="ECO:0000313|EMBL:ADK91205.1"
SQ SEQUENCE 225 AA; 25860 MW; 5186F9D2951E9E66 CRC64;
SRTMTDKYRL HLSVADLLFV FTLPFWSVDA AIGWYFKEFL CKAVHVIYTV NLYSSVLILA
FISLDRYLAI VHATNSQGSR KFLAEKIVYA GVWLPAILLT VPDLVFASVS DIEGNYVCDR
IYPLENREYW TIGFRFLHIT VGLVLPGIII LTCYCVIISK LSHSKGHQKR KALKTTVILI
LAFFACWLPY YICLTIDTFG LLRLLKFDCY IDNMLHKWIA ITEAL
//
