ID DL_DROME Reviewed; 833 AA.
AC P10041; Q6T3F7; Q6T3G1; Q6T3G7; Q6T3G8; Q6T3H0; Q6T3H3; Q6T3I3; Q6T3I5;
AC Q6T3I7; Q6T3J1; Q6T3J2; Q6T3J3; Q6T3J4; Q6T3K0; Q6T3K1; Q6T3K9; Q6T3L5;
AC Q6T3L7; Q6T3L9; Q6T3M2; Q6T3M4; Q6T3M7; Q6T3N1; Q6T3N3; Q6T3N5; Q6T3N7;
AC Q6T4M9; Q6T4N0; Q6T4N1; Q6T4N2; Q6T4N3; Q6T4N4; Q6T4N6; Q95RM9; Q99108;
AC Q9VDY2;
DT 01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2000, sequence version 2.
DT 27-MAR-2024, entry version 230.
DE RecName: Full=Neurogenic locus protein delta {ECO:0000303|PubMed:16453806};
DE Flags: Precursor;
GN Name=Delta {ECO:0000303|PubMed:16453806, ECO:0000312|FlyBase:FBgn0000463};
GN Synonyms=Dl; ORFNames=CG3619 {ECO:0000312|FlyBase:FBgn0000463};
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, AND
RP VARIANTS ALA-652 AND MET-662.
RC TISSUE=Embryo;
RX PubMed=16453806; DOI=10.1002/j.1460-2075.1987.tb02666.x;
RA Vaessin H., Bremer K.A., Knust E., Campos-Ortega J.A.;
RT "The neurogenic gene Delta of Drosophila melanogaster is expressed in
RT neurogenic territories and encodes a putative transmembrane protein with
RT EGF-like repeats.";
RL EMBO J. 6:3431-3440(1987).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA], AND VARIANT ALA-812.
RC STRAIN=Oregon-R; TISSUE=Embryo;
RX PubMed=3149249; DOI=10.1101/gad.2.12b.1723;
RA Kopczynski C.C., Alton A.K., Fechtel K., Kooh P.J., Muskavitch M.A.T.;
RT "Delta, a Drosophila neurogenic gene, is transcriptionally complex and
RT encodes a protein related to blood coagulation factors and epidermal growth
RT factor of vertebrates.";
RL Genes Dev. 2:1723-1735(1988).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=NapaValley1, NapaValley10, NapaValley11, NapaValley12, NapaValley2,
RC NapaValley3, NapaValley4, NapaValley5, NapaValley6, NapaValley7,
RC NapaValley8, NapaValley9, nps_1, nps_13, nps_14, nps_15, nps_16, nps_17,
RC nps_18, nps_19, nps_2, nps_20, nps_21, nps_23, nps_24, nps_25, nps_26,
RC nps_27, nps_28, nps_29, nps_3, nps_30, nps_31, nps_32, nps_33, nps_34,
RC nps_35, nps_36, nps_37, nps_38, nps_39, nps_4, nps_40, nps_41, nps_42,
RC nps_43, nps_44, nps_45, nps_46, nps_47, nps_48, nps_49, nps_5, nps_50,
RC nps_6, sonoma_002, sonoma_003, sonoma_004, sonoma_005, sonoma_006,
RC sonoma_007, sonoma_008, sonoma_009, sonoma_010, sonoma_013, sonoma_014,
RC sonoma_015, sonoma_016, sonoma_017, sonoma_019, sonoma_022, sonoma_023,
RC sonoma_024, sonoma_031, sonoma_032, sonoma_033, sonoma_034, sonoma_036,
RC sonoma_038, sonoma_039, sonoma_040, sonoma_045, sonoma_046, sonoma_048,
RC sonoma_050, sonoma_051, sonoma_053, sonoma_054, sonoma_055, sonoma_058,
RC sonoma_059, sonoma_061, sonoma_064, sonoma_073, sonoma_074, sonoma_081,
RC sonoma_085, sonoma_086, sonoma_087, sonoma_094, sonoma_095, sonoma_097,
RC sonoma_101, sonoma_106, sonoma_107, sonoma_111, sonoma_116, sonoma_117, and
RC sonoma_119;
RX PubMed=15020426; DOI=10.1534/genetics.166.1.291;
RA Genissel A., Pastinen T., Dowell A., Mackay T.F.C., Long A.D.;
RT "No evidence for an association between common nonsynonymous polymorphisms
RT in delta and bristle number variation in natural and laboratory populations
RT of Drosophila melanogaster.";
RL Genetics 166:291-306(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [5]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley; TISSUE=Embryo;
RA Stapleton M., Brokstein P., Hong L., Agbayani A., Carlson J.W., Champe M.,
RA Chavez C., Dorsett V., Dresnek D., Farfan D., Frise E., George R.A.,
RA Gonzalez M., Guarin H., Kronmiller B., Li P.W., Liao G., Miranda A.,
RA Mungall C.J., Nunoo J., Pacleb J.M., Paragas V., Park S., Patel S.,
RA Phouanenavong S., Wan K.H., Yu C., Lewis S.E., Rubin G.M., Celniker S.E.;
RL Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases.
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 195-833.
RC STRAIN=Berkeley; TISSUE=Embryo;
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
RN [8]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 422-621.
RC TISSUE=Embryo;
RX PubMed=3107986; DOI=10.1002/j.1460-2075.1987.tb04818.x;
RA Knust E., Dietrich U., Tepass U., Bremer K.A., Weigel D., Vaessin H.,
RA Campos-Ortega J.A.;
RT "EGF homologous sequences encoded in the genome of Drosophila melanogaster,
RT and their relation to neurogenic genes.";
RL EMBO J. 6:761-766(1987).
RN [9]
RP FUNCTION, AND INTERACTION WITH N.
RX PubMed=10935637; DOI=10.1038/35019075;
RA Bruckner K., Perez L., Clausen H., Cohen S.;
RT "Glycosyltransferase activity of Fringe modulates Notch-Delta
RT interactions.";
RL Nature 406:411-415(2000).
RN [10]
RP PATTERN OF TRANSCRIPTION, AND CHARACTERIZATION.
RX PubMed=2128477; DOI=10.1242/dev.110.3.905;
RA Haenlin M., Kramatschek B., Campos-Ortega J.A.;
RT "The pattern of transcription of the neurogenic gene Delta of Drosophila
RT melanogaster.";
RL Development 110:905-914(1990).
RN [11]
RP INTERACTION WITH MIB, AND UBIQUITINATION.
RX PubMed=15829515; DOI=10.1242/dev.01825;
RA Lai E.C., Roegiers F., Qin X., Jan Y.N., Rubin G.M.;
RT "The ubiquitin ligase Drosophila Mind bomb promotes Notch signaling by
RT regulating the localization and activity of Serrate and Delta.";
RL Development 132:2319-2332(2005).
RN [12]
RP UBIQUITINATION.
RX PubMed=15760269; DOI=10.1371/journal.pbio.0030096;
RA Le Borgne R., Remaud S., Hamel S., Schweisguth F.;
RT "Two distinct E3 ubiquitin ligases have complementary functions in the
RT regulation of delta and serrate signaling in Drosophila.";
RL PLoS Biol. 3:688-696(2005).
RN [13]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-666, AND IDENTIFICATION BY
RP MASS SPECTROMETRY.
RC TISSUE=Embryo;
RX PubMed=18327897; DOI=10.1021/pr700696a;
RA Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
RT "Phosphoproteome analysis of Drosophila melanogaster embryos.";
RL J. Proteome Res. 7:1675-1682(2008).
CC -!- FUNCTION: Acts as a ligand for Notch (N) receptor. Essential for proper
CC differentiation of ectoderm. Delta is required for the correct
CC separation of neural and epidermal cell lineages. Fringe (fng) acts in
CC the Golgi to determine the type of O-linked fucose on the EGF modules
CC in N, altering the ability of N to bind with Delta. O-fut1 also has a
CC role in modulating the interaction. {ECO:0000269|PubMed:10935637}.
CC -!- SUBUNIT: Interacts with Notch (N) via the EGF repeats and the N EGF
CC repeats. {ECO:0000269|PubMed:10935637, ECO:0000269|PubMed:15829515}.
CC -!- INTERACTION:
CC P10041; P07207: N; NbExp=2; IntAct=EBI-115346, EBI-103438;
CC -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
CC -!- TISSUE SPECIFICITY: Detected in all areas with neurogenic abilities,
CC for example the neurogenic ectoderm and the primordia of the sense
CC organs. Later expression is restricted to those cells that have adopted
CC a neural fate. {ECO:0000269|PubMed:16453806}.
CC -!- DEVELOPMENTAL STAGE: Expressed both maternally and zygotically.
CC Expression is highest early in embryonic development (stage 5) and
CC reduces to a low level during larval stages.
CC {ECO:0000269|PubMed:16453806}.
CC -!- PTM: Ubiquitinated by Mib, leading to its endocytosis and subsequent
CC degradation. {ECO:0000269|PubMed:15760269,
CC ECO:0000269|PubMed:15829515}.
CC -!- MISCELLANEOUS: Separation of neuroblasts from the ectoderm into the
CC inner part of embryo is one of the first steps of CNS development in
CC insects, this process is under control of the neurogenic genes.
CC -!- MISCELLANEOUS: Notch and Serrate may interact at the protein level, it
CC is conceivable that the Serrate and Delta proteins may compete for
CC binding with the Notch protein.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAL28817.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; X06289; CAA29617.1; -; mRNA.
DR EMBL; Y00222; CAA68369.1; -; mRNA.
DR EMBL; AY437145; AAR21453.1; -; Genomic_DNA.
DR EMBL; AY437140; AAR21453.1; JOINED; Genomic_DNA.
DR EMBL; AY437141; AAR21453.1; JOINED; Genomic_DNA.
DR EMBL; AY437142; AAR21453.1; JOINED; Genomic_DNA.
DR EMBL; AY437143; AAR21453.1; JOINED; Genomic_DNA.
DR EMBL; AY437144; AAR21453.1; JOINED; Genomic_DNA.
DR EMBL; AY437151; AAR21454.1; -; Genomic_DNA.
DR EMBL; AY437146; AAR21454.1; JOINED; Genomic_DNA.
DR EMBL; AY437147; AAR21454.1; JOINED; Genomic_DNA.
DR EMBL; AY437148; AAR21454.1; JOINED; Genomic_DNA.
DR EMBL; AY437149; AAR21454.1; JOINED; Genomic_DNA.
DR EMBL; AY437150; AAR21454.1; JOINED; Genomic_DNA.
DR EMBL; AY437157; AAR21455.1; -; Genomic_DNA.
DR EMBL; AY437152; AAR21455.1; JOINED; Genomic_DNA.
DR EMBL; AY437153; AAR21455.1; JOINED; Genomic_DNA.
DR EMBL; AY437154; AAR21455.1; JOINED; Genomic_DNA.
DR EMBL; AY437155; AAR21455.1; JOINED; Genomic_DNA.
DR EMBL; AY437156; AAR21455.1; JOINED; Genomic_DNA.
DR EMBL; AY437163; AAR21456.1; -; Genomic_DNA.
DR EMBL; AY437158; AAR21456.1; JOINED; Genomic_DNA.
DR EMBL; AY437159; AAR21456.1; JOINED; Genomic_DNA.
DR EMBL; AY437160; AAR21456.1; JOINED; Genomic_DNA.
DR EMBL; AY437161; AAR21456.1; JOINED; Genomic_DNA.
DR EMBL; AY437162; AAR21456.1; JOINED; Genomic_DNA.
DR EMBL; AY437169; AAR21457.1; -; Genomic_DNA.
DR EMBL; AY437164; AAR21457.1; JOINED; Genomic_DNA.
DR EMBL; AY437165; AAR21457.1; JOINED; Genomic_DNA.
DR EMBL; AY437166; AAR21457.1; JOINED; Genomic_DNA.
DR EMBL; AY437167; AAR21457.1; JOINED; Genomic_DNA.
DR EMBL; AY437168; AAR21457.1; JOINED; Genomic_DNA.
DR EMBL; AY437175; AAR21458.1; -; Genomic_DNA.
DR EMBL; AY437170; AAR21458.1; JOINED; Genomic_DNA.
DR EMBL; AY437171; AAR21458.1; JOINED; Genomic_DNA.
DR EMBL; AY437172; AAR21458.1; JOINED; Genomic_DNA.
DR EMBL; AY437173; AAR21458.1; JOINED; Genomic_DNA.
DR EMBL; AY437174; AAR21458.1; JOINED; Genomic_DNA.
DR EMBL; AY437181; AAR21459.1; -; Genomic_DNA.
DR EMBL; AY437176; AAR21459.1; JOINED; Genomic_DNA.
DR EMBL; AY437177; AAR21459.1; JOINED; Genomic_DNA.
DR EMBL; AY437178; AAR21459.1; JOINED; Genomic_DNA.
DR EMBL; AY437179; AAR21459.1; JOINED; Genomic_DNA.
DR EMBL; AY437180; AAR21459.1; JOINED; Genomic_DNA.
DR EMBL; AY437187; AAR21460.1; -; Genomic_DNA.
DR EMBL; AY437182; AAR21460.1; JOINED; Genomic_DNA.
DR EMBL; AY437183; AAR21460.1; JOINED; Genomic_DNA.
DR EMBL; AY437184; AAR21460.1; JOINED; Genomic_DNA.
DR EMBL; AY437185; AAR21460.1; JOINED; Genomic_DNA.
DR EMBL; AY437186; AAR21460.1; JOINED; Genomic_DNA.
DR EMBL; AY437193; AAR21461.1; -; Genomic_DNA.
DR EMBL; AY437188; AAR21461.1; JOINED; Genomic_DNA.
DR EMBL; AY437189; AAR21461.1; JOINED; Genomic_DNA.
DR EMBL; AY437190; AAR21461.1; JOINED; Genomic_DNA.
DR EMBL; AY437191; AAR21461.1; JOINED; Genomic_DNA.
DR EMBL; AY437192; AAR21461.1; JOINED; Genomic_DNA.
DR EMBL; AY437199; AAR21462.1; -; Genomic_DNA.
DR EMBL; AY437194; AAR21462.1; JOINED; Genomic_DNA.
DR EMBL; AY437195; AAR21462.1; JOINED; Genomic_DNA.
DR EMBL; AY437196; AAR21462.1; JOINED; Genomic_DNA.
DR EMBL; AY437197; AAR21462.1; JOINED; Genomic_DNA.
DR EMBL; AY437198; AAR21462.1; JOINED; Genomic_DNA.
DR EMBL; AY437205; AAR21463.1; -; Genomic_DNA.
DR EMBL; AY437200; AAR21463.1; JOINED; Genomic_DNA.
DR EMBL; AY437201; AAR21463.1; JOINED; Genomic_DNA.
DR EMBL; AY437202; AAR21463.1; JOINED; Genomic_DNA.
DR EMBL; AY437203; AAR21463.1; JOINED; Genomic_DNA.
DR EMBL; AY437204; AAR21463.1; JOINED; Genomic_DNA.
DR EMBL; AY437211; AAR21464.1; -; Genomic_DNA.
DR EMBL; AY437206; AAR21464.1; JOINED; Genomic_DNA.
DR EMBL; AY437207; AAR21464.1; JOINED; Genomic_DNA.
DR EMBL; AY437208; AAR21464.1; JOINED; Genomic_DNA.
DR EMBL; AY437209; AAR21464.1; JOINED; Genomic_DNA.
DR EMBL; AY437210; AAR21464.1; JOINED; Genomic_DNA.
DR EMBL; AY437217; AAR21465.1; -; Genomic_DNA.
DR EMBL; AY437212; AAR21465.1; JOINED; Genomic_DNA.
DR EMBL; AY437213; AAR21465.1; JOINED; Genomic_DNA.
DR EMBL; AY437214; AAR21465.1; JOINED; Genomic_DNA.
DR EMBL; AY437215; AAR21465.1; JOINED; Genomic_DNA.
DR EMBL; AY437216; AAR21465.1; JOINED; Genomic_DNA.
DR EMBL; AY437223; AAR21466.1; -; Genomic_DNA.
DR EMBL; AY437218; AAR21466.1; JOINED; Genomic_DNA.
DR EMBL; AY437219; AAR21466.1; JOINED; Genomic_DNA.
DR EMBL; AY437220; AAR21466.1; JOINED; Genomic_DNA.
DR EMBL; AY437221; AAR21466.1; JOINED; Genomic_DNA.
DR EMBL; AY437222; AAR21466.1; JOINED; Genomic_DNA.
DR EMBL; AY437229; AAR21467.1; -; Genomic_DNA.
DR EMBL; AY437224; AAR21467.1; JOINED; Genomic_DNA.
DR EMBL; AY437225; AAR21467.1; JOINED; Genomic_DNA.
DR EMBL; AY437226; AAR21467.1; JOINED; Genomic_DNA.
DR EMBL; AY437227; AAR21467.1; JOINED; Genomic_DNA.
DR EMBL; AY437228; AAR21467.1; JOINED; Genomic_DNA.
DR EMBL; AY437235; AAR21468.1; -; Genomic_DNA.
DR EMBL; AY437230; AAR21468.1; JOINED; Genomic_DNA.
DR EMBL; AY437231; AAR21468.1; JOINED; Genomic_DNA.
DR EMBL; AY437232; AAR21468.1; JOINED; Genomic_DNA.
DR EMBL; AY437233; AAR21468.1; JOINED; Genomic_DNA.
DR EMBL; AY437234; AAR21468.1; JOINED; Genomic_DNA.
DR EMBL; AY438104; AAR21469.1; -; Genomic_DNA.
DR EMBL; AY438105; AAR21470.1; -; Genomic_DNA.
DR EMBL; AY438106; AAR21471.1; -; Genomic_DNA.
DR EMBL; AY438107; AAR21472.1; -; Genomic_DNA.
DR EMBL; AY438108; AAR21473.1; -; Genomic_DNA.
DR EMBL; AY438109; AAR21474.1; -; Genomic_DNA.
DR EMBL; AY438110; AAR21475.1; -; Genomic_DNA.
DR EMBL; AY438111; AAR21476.1; -; Genomic_DNA.
DR EMBL; AY438112; AAR21477.1; -; Genomic_DNA.
DR EMBL; AY438113; AAR21478.1; -; Genomic_DNA.
DR EMBL; AY438114; AAR21479.1; -; Genomic_DNA.
DR EMBL; AY438115; AAR21480.1; -; Genomic_DNA.
DR EMBL; AY438116; AAR21481.1; -; Genomic_DNA.
DR EMBL; AY438117; AAR21482.1; -; Genomic_DNA.
DR EMBL; AY438118; AAR21483.1; -; Genomic_DNA.
DR EMBL; AY438119; AAR21484.1; -; Genomic_DNA.
DR EMBL; AY438120; AAR21485.1; -; Genomic_DNA.
DR EMBL; AY438121; AAR21486.1; -; Genomic_DNA.
DR EMBL; AY438122; AAR21487.1; -; Genomic_DNA.
DR EMBL; AY438123; AAR21488.1; -; Genomic_DNA.
DR EMBL; AY438124; AAR21489.1; -; Genomic_DNA.
DR EMBL; AY438125; AAR21490.1; -; Genomic_DNA.
DR EMBL; AY438126; AAR21491.1; -; Genomic_DNA.
DR EMBL; AY438127; AAR21492.1; -; Genomic_DNA.
DR EMBL; AY438128; AAR21493.1; -; Genomic_DNA.
DR EMBL; AY438129; AAR21494.1; -; Genomic_DNA.
DR EMBL; AY438130; AAR21495.1; -; Genomic_DNA.
DR EMBL; AY438131; AAR21496.1; -; Genomic_DNA.
DR EMBL; AY438132; AAR21497.1; -; Genomic_DNA.
DR EMBL; AY438133; AAR21498.1; -; Genomic_DNA.
DR EMBL; AY438134; AAR21499.1; -; Genomic_DNA.
DR EMBL; AY438135; AAR21500.1; -; Genomic_DNA.
DR EMBL; AY438136; AAR21501.1; -; Genomic_DNA.
DR EMBL; AY438137; AAR21502.1; -; Genomic_DNA.
DR EMBL; AY438138; AAR21503.1; -; Genomic_DNA.
DR EMBL; AY438139; AAR21504.1; -; Genomic_DNA.
DR EMBL; AY438140; AAR21505.1; -; Genomic_DNA.
DR EMBL; AY438141; AAR21506.1; -; Genomic_DNA.
DR EMBL; AY438147; AAR09172.1; -; Genomic_DNA.
DR EMBL; AY438148; AAR09173.1; -; Genomic_DNA.
DR EMBL; AY438149; AAR09174.1; -; Genomic_DNA.
DR EMBL; AY438150; AAR09175.1; -; Genomic_DNA.
DR EMBL; AY438151; AAR09176.1; -; Genomic_DNA.
DR EMBL; AY438152; AAR09177.1; -; Genomic_DNA.
DR EMBL; AY438153; AAR09178.1; -; Genomic_DNA.
DR EMBL; AY438154; AAR09179.1; -; Genomic_DNA.
DR EMBL; AY438155; AAR09180.1; -; Genomic_DNA.
DR EMBL; AY438156; AAR09181.1; -; Genomic_DNA.
DR EMBL; AY438157; AAR09182.1; -; Genomic_DNA.
DR EMBL; AY438158; AAR09183.1; -; Genomic_DNA.
DR EMBL; AY438159; AAR09184.1; -; Genomic_DNA.
DR EMBL; AY438160; AAR09185.1; -; Genomic_DNA.
DR EMBL; AY438161; AAR09186.1; -; Genomic_DNA.
DR EMBL; AY438162; AAR09187.1; -; Genomic_DNA.
DR EMBL; AY438163; AAR09188.1; -; Genomic_DNA.
DR EMBL; AY438164; AAR09189.1; -; Genomic_DNA.
DR EMBL; AY438165; AAR09190.1; -; Genomic_DNA.
DR EMBL; AY438166; AAR09191.1; -; Genomic_DNA.
DR EMBL; AY438167; AAR09192.1; -; Genomic_DNA.
DR EMBL; AY438168; AAR09193.1; -; Genomic_DNA.
DR EMBL; AY438169; AAR09194.1; -; Genomic_DNA.
DR EMBL; AY438170; AAR09195.1; -; Genomic_DNA.
DR EMBL; AY438171; AAR09196.1; -; Genomic_DNA.
DR EMBL; AY438172; AAR09197.1; -; Genomic_DNA.
DR EMBL; AY438173; AAR09198.1; -; Genomic_DNA.
DR EMBL; AY438174; AAR09199.1; -; Genomic_DNA.
DR EMBL; AY438175; AAR09200.1; -; Genomic_DNA.
DR EMBL; AY438176; AAR09201.1; -; Genomic_DNA.
DR EMBL; AY438177; AAR09202.1; -; Genomic_DNA.
DR EMBL; AY438178; AAR09203.1; -; Genomic_DNA.
DR EMBL; AY438179; AAR09204.1; -; Genomic_DNA.
DR EMBL; AY438180; AAR09205.1; -; Genomic_DNA.
DR EMBL; AY438181; AAR09206.1; -; Genomic_DNA.
DR EMBL; AY438182; AAR09207.1; -; Genomic_DNA.
DR EMBL; AY438183; AAR09208.1; -; Genomic_DNA.
DR EMBL; AY438184; AAR09209.1; -; Genomic_DNA.
DR EMBL; AY438185; AAR09210.1; -; Genomic_DNA.
DR EMBL; AY438186; AAR09211.1; -; Genomic_DNA.
DR EMBL; AY438187; AAR09212.1; -; Genomic_DNA.
DR EMBL; AY438188; AAR09213.1; -; Genomic_DNA.
DR EMBL; AY438189; AAR09214.1; -; Genomic_DNA.
DR EMBL; AY438190; AAR09215.1; -; Genomic_DNA.
DR EMBL; AY438191; AAR09216.1; -; Genomic_DNA.
DR EMBL; AY438192; AAR09217.1; -; Genomic_DNA.
DR EMBL; AY438193; AAR09218.1; -; Genomic_DNA.
DR EMBL; AY438194; AAR09219.1; -; Genomic_DNA.
DR EMBL; AY438195; AAR09220.1; -; Genomic_DNA.
DR EMBL; AY438196; AAR09221.1; -; Genomic_DNA.
DR EMBL; AY438197; AAR09222.1; -; Genomic_DNA.
DR EMBL; AY438198; AAR09223.1; -; Genomic_DNA.
DR EMBL; AY438199; AAR09224.1; -; Genomic_DNA.
DR EMBL; AY438200; AAR09225.1; -; Genomic_DNA.
DR EMBL; AY438201; AAR09226.1; -; Genomic_DNA.
DR EMBL; AY438202; AAR09227.1; -; Genomic_DNA.
DR EMBL; BK004004; DAA02303.1; -; Genomic_DNA.
DR EMBL; AE014297; AAF55657.1; -; Genomic_DNA.
DR EMBL; BT003267; AAO25024.1; -; mRNA.
DR EMBL; AY061269; AAL28817.1; ALT_INIT; mRNA.
DR EMBL; X05140; CAA28786.1; -; mRNA.
DR PIR; A31246; A31246.
DR PIR; A43564; A43564.
DR PIR; S00670; S00670.
DR PIR; S19087; S19087.
DR RefSeq; NP_001247193.1; NM_001260264.2.
DR RefSeq; NP_477264.1; NM_057916.4.
DR RefSeq; NP_732412.1; NM_169853.3.
DR PDB; 4XIB; X-ray; 2.15 A; C=680-690.
DR PDB; 7ALK; X-ray; 3.00 A; A=23-258.
DR PDBsum; 4XIB; -.
DR PDBsum; 7ALK; -.
DR AlphaFoldDB; P10041; -.
DR SMR; P10041; -.
DR BioGRID; 67310; 133.
DR DIP; DIP-22726N; -.
DR IntAct; P10041; 4.
DR STRING; 7227.FBpp0083153; -.
DR GlyCosmos; P10041; 3 sites, No reported glycans.
DR GlyGen; P10041; 3 sites.
DR iPTMnet; P10041; -.
DR PaxDb; 7227-FBpp0083153; -.
DR EnsemblMetazoa; FBtr0083739; FBpp0083153; FBgn0000463.
DR EnsemblMetazoa; FBtr0083740; FBpp0083154; FBgn0000463.
DR EnsemblMetazoa; FBtr0304658; FBpp0293200; FBgn0000463.
DR GeneID; 42313; -.
DR KEGG; dme:Dmel_CG3619; -.
DR AGR; FB:FBgn0000463; -.
DR FlyBase; FBgn0000463; Delta.
DR VEuPathDB; VectorBase:FBgn0000463; -.
DR eggNOG; KOG1217; Eukaryota.
DR GeneTree; ENSGT00940000170295; -.
DR HOGENOM; CLU_012574_0_1_1; -.
DR InParanoid; P10041; -.
DR OMA; SNEHGRD; -.
DR OrthoDB; 5475408at2759; -.
DR PhylomeDB; P10041; -.
DR SignaLink; P10041; -.
DR BioGRID-ORCS; 42313; 0 hits in 1 CRISPR screen.
DR ChiTaRS; Dl; fly.
DR GenomeRNAi; 42313; -.
DR PRO; PR:P10041; -.
DR Proteomes; UP000000803; Chromosome 3R.
DR Bgee; FBgn0000463; Expressed in germ layer and 115 other cell types or tissues.
DR ExpressionAtlas; P10041; baseline and differential.
DR Genevisible; P10041; DM.
DR GO; GO:0045179; C:apical cortex; IDA:FlyBase.
DR GO; GO:0009986; C:cell surface; IDA:FlyBase.
DR GO; GO:0031410; C:cytoplasmic vesicle; IDA:FlyBase.
DR GO; GO:0005769; C:early endosome; IDA:FlyBase.
DR GO; GO:0030139; C:endocytic vesicle; IDA:FlyBase.
DR GO; GO:0005768; C:endosome; IDA:FlyBase.
DR GO; GO:0016020; C:membrane; IDA:FlyBase.
DR GO; GO:0005886; C:plasma membrane; IDA:FlyBase.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0043208; F:glycosphingolipid binding; IDA:FlyBase.
DR GO; GO:0005112; F:Notch binding; IDA:FlyBase.
DR GO; GO:0048018; F:receptor ligand activity; IDA:FlyBase.
DR GO; GO:0007015; P:actin filament organization; IMP:FlyBase.
DR GO; GO:0048800; P:antennal morphogenesis; IMP:FlyBase.
DR GO; GO:0007475; P:apposition of dorsal and ventral imaginal disc-derived wing surfaces; IMP:FlyBase.
DR GO; GO:0008356; P:asymmetric cell division; TAS:FlyBase.
DR GO; GO:0007298; P:border follicle cell migration; IMP:FlyBase.
DR GO; GO:0001708; P:cell fate specification; TAS:FlyBase.
DR GO; GO:0008407; P:chaeta morphogenesis; IMP:FlyBase.
DR GO; GO:0042051; P:compound eye photoreceptor development; IMP:FlyBase.
DR GO; GO:0046667; P:compound eye retinal cell programmed cell death; TAS:FlyBase.
DR GO; GO:0030707; P:follicle cell of egg chamber development; IMP:FlyBase.
DR GO; GO:0030713; P:follicle cell of egg chamber stalk formation; IMP:FlyBase.
DR GO; GO:0030718; P:germ-line stem cell population maintenance; IMP:FlyBase.
DR GO; GO:0008347; P:glial cell migration; IMP:FlyBase.
DR GO; GO:0007480; P:imaginal disc-derived leg morphogenesis; IMP:FlyBase.
DR GO; GO:0036011; P:imaginal disc-derived leg segmentation; IMP:FlyBase.
DR GO; GO:0008587; P:imaginal disc-derived wing margin morphogenesis; IMP:FlyBase.
DR GO; GO:0007476; P:imaginal disc-derived wing morphogenesis; IMP:FlyBase.
DR GO; GO:0046331; P:lateral inhibition; IMP:FlyBase.
DR GO; GO:0007498; P:mesoderm development; IMP:FlyBase.
DR GO; GO:0007400; P:neuroblast fate determination; IMP:FlyBase.
DR GO; GO:0048665; P:neuron fate specification; IMP:FlyBase.
DR GO; GO:0007219; P:Notch signaling pathway; IDA:FlyBase.
DR GO; GO:0030720; P:oocyte localization involved in germarium-derived egg chamber formation; IMP:FlyBase.
DR GO; GO:0048477; P:oogenesis; IMP:FlyBase.
DR GO; GO:0007422; P:peripheral nervous system development; IMP:FlyBase.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; IMP:FlyBase.
DR GO; GO:0045931; P:positive regulation of mitotic cell cycle; IMP:FlyBase.
DR GO; GO:0048056; P:R3/R4 cell differentiation; IMP:FlyBase.
DR GO; GO:0045466; P:R7 cell differentiation; IMP:FlyBase.
DR GO; GO:0090175; P:regulation of establishment of planar polarity; IGI:FlyBase.
DR GO; GO:0016330; P:second mitotic wave involved in compound eye morphogenesis; IMP:FlyBase.
DR GO; GO:0007423; P:sensory organ development; IMP:FlyBase.
DR GO; GO:0048863; P:stem cell differentiation; IMP:FlyBase.
DR GO; GO:0048100; P:wing disc anterior/posterior pattern formation; IMP:FlyBase.
DR GO; GO:0048190; P:wing disc dorsal/ventral pattern formation; IMP:FlyBase.
DR CDD; cd00054; EGF_CA; 6.
DR Gene3D; 2.10.25.140; -; 1.
DR Gene3D; 2.60.40.3510; -; 1.
DR Gene3D; 2.10.25.10; Laminin; 8.
DR InterPro; IPR001774; DSL.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR013032; EGF-like_CS.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR011651; Notch_ligand_N.
DR PANTHER; PTHR24044:SF420; NEUROGENIC LOCUS PROTEIN DELTA; 1.
DR PANTHER; PTHR24044; NOTCH LIGAND FAMILY MEMBER; 1.
DR Pfam; PF21700; DL-JAG_EGF-like; 2.
DR Pfam; PF01414; DSL; 1.
DR Pfam; PF00008; EGF; 6.
DR Pfam; PF12661; hEGF; 1.
DR Pfam; PF07657; MNNL; 1.
DR SMART; SM00051; DSL; 1.
DR SMART; SM00181; EGF; 9.
DR SMART; SM00179; EGF_CA; 7.
DR SUPFAM; SSF57196; EGF/Laminin; 3.
DR SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR PROSITE; PS00010; ASX_HYDROXYL; 3.
DR PROSITE; PS51051; DSL; 1.
DR PROSITE; PS00022; EGF_1; 9.
DR PROSITE; PS01186; EGF_2; 9.
DR PROSITE; PS50026; EGF_3; 7.
DR PROSITE; PS01187; EGF_CA; 2.
PE 1: Evidence at protein level;
KW 3D-structure; Developmental protein; Differentiation; Disulfide bond;
KW EGF-like domain; Glycoprotein; Membrane; Neurogenesis;
KW Notch signaling pathway; Phosphoprotein; Reference proteome; Repeat;
KW Signal; Transmembrane; Transmembrane helix; Ubl conjugation.
FT SIGNAL 1..18
FT /evidence="ECO:0000255"
FT CHAIN 19..833
FT /note="Neurogenic locus protein delta"
FT /id="PRO_0000007505"
FT TOPO_DOM 19..594
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 595..617
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 618..833
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 182..226
FT /note="DSL"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00377"
FT DOMAIN 227..258
FT /note="EGF-like 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 256..289
FT /note="EGF-like 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 291..329
FT /note="EGF-like 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 331..372
FT /note="EGF-like 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 374..416
FT /note="EGF-like 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 418..451
FT /note="EGF-like 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 453..489
FT /note="EGF-like 7; calcium-binding"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 491..527
FT /note="EGF-like 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 529..565
FT /note="EGF-like 9; calcium-binding"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT REGION 743..773
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 666
FT /note="Phosphothreonine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT CARBOHYD 98
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 137
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 167
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 46..61
FT /evidence="ECO:0000250|UniProtKB:D3ZHH1"
FT DISULFID 68..82
FT /evidence="ECO:0000250|UniProtKB:D3ZHH1"
FT DISULFID 184..193
FT /evidence="ECO:0000250|UniProtKB:D3ZHH1,
FT ECO:0000255|PROSITE-ProRule:PRU00377"
FT DISULFID 197..209
FT /evidence="ECO:0000250|UniProtKB:D3ZHH1,
FT ECO:0000255|PROSITE-ProRule:PRU00377"
FT DISULFID 217..226
FT /evidence="ECO:0000250|UniProtKB:D3ZHH1,
FT ECO:0000255|PROSITE-ProRule:PRU00377"
FT DISULFID 231..240
FT /evidence="ECO:0000250|UniProtKB:D3ZHH1,
FT ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 235..246
FT /evidence="ECO:0000250|UniProtKB:D3ZHH1,
FT ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 248..257
FT /evidence="ECO:0000250|UniProtKB:D3ZHH1,
FT ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 260..271
FT /evidence="ECO:0000250|UniProtKB:D3ZHH1"
FT DISULFID 266..277
FT /evidence="ECO:0000250|UniProtKB:D3ZHH1"
FT DISULFID 279..288
FT /evidence="ECO:0000250|UniProtKB:D3ZHH1,
FT ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 295..307
FT /evidence="ECO:0000250"
FT DISULFID 301..317
FT /evidence="ECO:0000250"
FT DISULFID 319..328
FT /evidence="ECO:0000250"
FT DISULFID 335..348
FT /evidence="ECO:0000250"
FT DISULFID 342..360
FT /evidence="ECO:0000250"
FT DISULFID 362..371
FT /evidence="ECO:0000250"
FT DISULFID 378..388
FT /evidence="ECO:0000250"
FT DISULFID 383..404
FT /evidence="ECO:0000250"
FT DISULFID 406..415
FT /evidence="ECO:0000250"
FT DISULFID 422..433
FT /evidence="ECO:0000250"
FT DISULFID 427..439
FT /evidence="ECO:0000250"
FT DISULFID 441..450
FT /evidence="ECO:0000250"
FT DISULFID 457..468
FT /evidence="ECO:0000250"
FT DISULFID 462..477
FT /evidence="ECO:0000250"
FT DISULFID 479..488
FT /evidence="ECO:0000250"
FT DISULFID 495..506
FT /evidence="ECO:0000250"
FT DISULFID 500..515
FT /evidence="ECO:0000250"
FT DISULFID 517..526
FT /evidence="ECO:0000250"
FT DISULFID 533..544
FT /evidence="ECO:0000250"
FT DISULFID 538..553
FT /evidence="ECO:0000250"
FT DISULFID 555..564
FT /evidence="ECO:0000250"
FT VARIANT 398
FT /note="K -> R (in strain: sonoma_017)"
FT VARIANT 443
FT /note="A -> T (in strain: sonoma_009, sonoma_051,
FT sonoma_053 and sonoma_054)"
FT VARIANT 461
FT /note="Q -> K (in strain: sonoma_010, sonoma_013,
FT sonoma_019 and sonoma_117)"
FT VARIANT 652
FT /note="G -> A (in strain: NapaValley5, NapaValley12,
FT sonoma_015, sonoma_016, sonoma_023, sonoma_032, sonoma_034,
FT sonoma_038, sonoma_040, sonoma_045, sonoma_048, sonoma_050,
FT sonoma_061, sonoma_073, sonoma_081, sonoma_085, sonoma_094,
FT sonoma_097 and sonoma_119)"
FT /evidence="ECO:0000269|PubMed:16453806"
FT VARIANT 662
FT /note="L -> M (in strain: sonoma_008, sonoma_015,
FT sonoma_016, sonoma_032, sonoma_034, sonoma_038, sonoma_040,
FT sonoma_045, sonoma_048, sonoma_050, sonoma_061, sonoma_073,
FT sonoma_081, sonoma_085, sonoma_094 and sonoma_097)"
FT /evidence="ECO:0000269|PubMed:16453806"
FT VARIANT 761
FT /note="A -> T (in strain: sonoma_006, sonoma_022 and
FT sonoma_040)"
FT VARIANT 787
FT /note="S -> G (in strain: nps_6, nps_18, nps_34, sonoma_048
FT and sonoma_050)"
FT VARIANT 800
FT /note="G -> R (in strain: sonoma_002)"
FT VARIANT 812
FT /note="V -> A (in strain: nps_19, nps_21, nps_25, nps_26,
FT nps_27, nps_30, nps_31, nps_33, nps_35, nps_42, nps_43,
FT nps_45, nps_47, sonoma_002, sonoma_003, sonoma_004,
FT sonoma_005, sonoma_006, sonoma_007, sonoma_008, sonoma_009,
FT sonoma_014, sonoma_016, sonoma_017, sonoma_022, sonoma_024,
FT sonoma_032, sonoma_033, sonoma_036, sonoma_038, sonoma_045,
FT sonoma_051, sonoma_053, sonoma_054, sonoma_055, sonoma_059,
FT sonoma_061, sonoma_064, sonoma_081, sonoma_086, sonoma_087,
FT sonoma_094, sonoma_095, sonoma_097, sonoma_106, sonoma_107
FT and sonoma_119)"
FT /evidence="ECO:0000269|PubMed:3149249"
FT CONFLICT 437..438
FT /note="GK -> ET (in Ref. 8; CAA28786)"
FT /evidence="ECO:0000305"
FT CONFLICT 443
FT /note="A -> S (in Ref. 8; CAA28786)"
FT /evidence="ECO:0000305"
FT CONFLICT 459
FT /note="G -> A (in Ref. 8; CAA28786)"
FT /evidence="ECO:0000305"
FT CONFLICT 490
FT /note="S -> T (in Ref. 8; CAA28786)"
FT /evidence="ECO:0000305"
FT CONFLICT 591
FT /note="T -> A (in Ref. 8; CAA28786)"
FT /evidence="ECO:0000305"
FT STRAND 25..34
FT /evidence="ECO:0007829|PDB:7ALK"
FT STRAND 43..47
FT /evidence="ECO:0007829|PDB:7ALK"
FT STRAND 52..54
FT /evidence="ECO:0007829|PDB:7ALK"
FT STRAND 57..59
FT /evidence="ECO:0007829|PDB:7ALK"
FT STRAND 62..70
FT /evidence="ECO:0007829|PDB:7ALK"
FT STRAND 78..80
FT /evidence="ECO:0007829|PDB:7ALK"
FT STRAND 83..88
FT /evidence="ECO:0007829|PDB:7ALK"
FT STRAND 93..98
FT /evidence="ECO:0007829|PDB:7ALK"
FT STRAND 112..117
FT /evidence="ECO:0007829|PDB:7ALK"
FT STRAND 124..135
FT /evidence="ECO:0007829|PDB:7ALK"
FT STRAND 146..157
FT /evidence="ECO:0007829|PDB:7ALK"
FT STRAND 165..170
FT /evidence="ECO:0007829|PDB:7ALK"
FT STRAND 175..183
FT /evidence="ECO:0007829|PDB:7ALK"
FT TURN 190..193
FT /evidence="ECO:0007829|PDB:7ALK"
FT STRAND 200..202
FT /evidence="ECO:0007829|PDB:7ALK"
FT STRAND 205..209
FT /evidence="ECO:0007829|PDB:7ALK"
FT STRAND 211..213
FT /evidence="ECO:0007829|PDB:7ALK"
FT STRAND 215..217
FT /evidence="ECO:0007829|PDB:7ALK"
FT STRAND 221..225
FT /evidence="ECO:0007829|PDB:7ALK"
FT STRAND 241..244
FT /evidence="ECO:0007829|PDB:7ALK"
FT TURN 254..257
FT /evidence="ECO:0007829|PDB:7ALK"
SQ SEQUENCE 833 AA; 88841 MW; EDBA107A0003D9A1 CRC64;
MHWIKCLLTA FICFTVIVQV HSSGSFELRL KYFSNDHGRD NEGRCCSGES DGATGKCLGS
CKTRFRVCLK HYQATIDTTS QCTYGDVITP ILGENSVNLT DAQRFQNKGF TNPIQFPFSF
SWPGTFSLIV EAWHDTNNSG NARTNKLLIQ RLLVQQVLEV SSEWKTNKSE SQYTSLEYDF
RVTCDLNYYG SGCAKFCRPR DDSFGHSTCS ETGEIICLTG WQGDYCHIPK CAKGCEHGHC
DKPNQCVCQL GWKGALCNEC VLEPNCIHGT CNKPWTCICN EGWGGLYCNQ DLNYCTNHRP
CKNGGTCFNT GEGLYTCKCA PGYSGDDCEN EIYSCDADVN PCQNGGTCID EPHTKTGYKC
HCANGWSGKM CEEKVLTCSD KPCHQGICRN VRPGLGSKGQ GYQCECPIGY SGPNCDLQLD
NCSPNPCING GSCQPSGKCI CPAGFSGTRC ETNIDDCLGH QCENGGTCID MVNQYRCQCV
PGFHGTHCSS KVDLCLIRPC ANGGTCLNLN NDYQCTCRAG FTGKDCSVDI DECSSGPCHN
GGTCMNRVNS FECVCANGFR GKQCDEESYD SVTFDAHQYG ATTQARADGL TNAQVVLIAV
FSVAMPLVAV IAACVVFCMK RKRKRAQEKD DAEARKQNEQ NAVATMHHNG SGVGVALASA
SLGGKTGSNS GLTFDGGNPN IIKNTWDKSV NNICASAAAA AAAAAAADEC LMYGGYVASV
ADNNNANSDF CVAPLQRAKS QKQLNTDPTL MHRGSPAGSS AKGASGGGPG AAEGKRISVL
GEGSYCSQRW PSLAAAGVAG ACSSQLMAAA SVAGSGAGTA QQQRSVVCGT PHM
//
