ID   DNAA_WOLSP              Reviewed;         186 AA.
AC   P35907;
DT   01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-1994, sequence version 1.
DT   03-MAY-2023, entry version 88.
DE   RecName: Full=Chromosomal replication initiator protein DnaA;
DE   Flags: Fragment;
GN   Name=dnaA;
OS   Wolbachia sp.
OC   Bacteria; Pseudomonadota; Alphaproteobacteria; Rickettsiales;
OC   Anaplasmataceae; Wolbachieae; Wolbachia.
OX   NCBI_TaxID=956;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=7894745; DOI=10.1111/j.1365-2583.1994.tb00160.x;
RA   Bourtzis K., Nirgianaki A., Onyango P., Savakis C.;
RT   "A prokaryotic dnaA sequence in Drosophila melanogaster: Wolbachia
RT   infection and cytoplasmic incompatibility among laboratory strains.";
RL   Insect Mol. Biol. 3:131-142(1994).
CC   -!- FUNCTION: Plays an important role in the initiation and regulation of
CC       chromosomal replication. Binds to the origin of replication; it binds
CC       specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-
CC       TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000305}.
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DR   EMBL; Z28981; CAA82285.1; -; Genomic_DNA.
DR   PIR; S39317; S39317.
DR   AlphaFoldDB; P35907; -.
DR   SMR; P35907; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:InterPro.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:InterPro.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   Gene3D; 1.10.8.60; -; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050; CHROMOSOMAL REPLICATION INITIATOR PROTEIN DNAA; 1.
DR   PANTHER; PTHR30050:SF2; CHROMOSOMAL REPLICATION INITIATOR PROTEIN DNAA; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   SUPFAM; SSF48295; TrpR-like; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Cytoplasm; DNA replication; DNA-binding; Nucleotide-binding.
FT   CHAIN           <1..>186
FT                   /note="Chromosomal replication initiator protein DnaA"
FT                   /id="PRO_0000114302"
FT   NON_TER         1
FT   NON_TER         186
SQ   SEQUENCE   186 AA;  21283 MW;  C423C06CEFFB0459 CRC64;
     EFFKTFNALI DQNKQLVISA DRSPSDLDGV EERIKSRLGW GLVADINETT FELRLGILQA
     KVEQMNMYVP KDVLEFLARN IKSNIRELEG ALNKVTHTSL IGRSMTVESA SETLIDLLRS
     NHRSVTIEEI QKKVAEFFNI KVADMQSNRR LRSLARPRQI AMYFAKKFTQ KSLPDIGRNF
     GGRDHT
//