ID DRL25_ARATH Reviewed; 1201 AA.
AC P0CB16; O50052;
DT 28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT 31-MAY-2011, sequence version 2.
DT 27-MAR-2024, entry version 94.
DE RecName: Full=Putative disease resistance protein At4g19050;
GN OrderedLocusNames=At4g19050; ORFNames=F13C5.220, T18B16.1;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617198; DOI=10.1038/47134;
RA Mayer K.F.X., Schueller C., Wambutt R., Murphy G., Volckaert G., Pohl T.,
RA Duesterhoeft A., Stiekema W., Entian K.-D., Terryn N., Harris B.,
RA Ansorge W., Brandt P., Grivell L.A., Rieger M., Weichselgartner M.,
RA de Simone V., Obermaier B., Mache R., Mueller M., Kreis M., Delseny M.,
RA Puigdomenech P., Watson M., Schmidtheini T., Reichert B., Portetelle D.,
RA Perez-Alonso M., Boutry M., Bancroft I., Vos P., Hoheisel J.,
RA Zimmermann W., Wedler H., Ridley P., Langham S.-A., McCullagh B.,
RA Bilham L., Robben J., van der Schueren J., Grymonprez B., Chuang Y.-J.,
RA Vandenbussche F., Braeken M., Weltjens I., Voet M., Bastiaens I., Aert R.,
RA Defoor E., Weitzenegger T., Bothe G., Ramsperger U., Hilbert H., Braun M.,
RA Holzer E., Brandt A., Peters S., van Staveren M., Dirkse W., Mooijman P.,
RA Klein Lankhorst R., Rose M., Hauf J., Koetter P., Berneiser S., Hempel S.,
RA Feldpausch M., Lamberth S., Van den Daele H., De Keyser A., Buysshaert C.,
RA Gielen J., Villarroel R., De Clercq R., van Montagu M., Rogers J.,
RA Cronin A., Quail M.A., Bray-Allen S., Clark L., Doggett J., Hall S.,
RA Kay M., Lennard N., McLay K., Mayes R., Pettett A., Rajandream M.A.,
RA Lyne M., Benes V., Rechmann S., Borkova D., Bloecker H., Scharfe M.,
RA Grimm M., Loehnert T.-H., Dose S., de Haan M., Maarse A.C., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Fartmann B., Granderath K., Dauner D.,
RA Herzl A., Neumann S., Argiriou A., Vitale D., Liguori R., Piravandi E.,
RA Massenet O., Quigley F., Clabauld G., Muendlein A., Felber R., Schnabl S.,
RA Hiller R., Schmidt W., Lecharny A., Aubourg S., Chefdor F., Cooke R.,
RA Berger C., Monfort A., Casacuberta E., Gibbons T., Weber N., Vandenbol M.,
RA Bargues M., Terol J., Torres A., Perez-Perez A., Purnelle B., Bent E.,
RA Johnson S., Tacon D., Jesse T., Heijnen L., Schwarz S., Scholler P.,
RA Heber S., Francs P., Bielke C., Frishman D., Haase D., Lemcke K.,
RA Mewes H.-W., Stocker S., Zaccaria P., Bevan M., Wilson R.K.,
RA de la Bastide M., Habermann K., Parnell L., Dedhia N., Gnoj L., Schutz K.,
RA Huang E., Spiegel L., Sekhon M., Murray J., Sheet P., Cordes M.,
RA Abu-Threideh J., Stoneking T., Kalicki J., Graves T., Harmon G.,
RA Edwards J., Latreille P., Courtney L., Cloud J., Abbott A., Scott K.,
RA Johnson D., Minx P., Bentley D., Fulton B., Miller N., Greco T., Kemp K.,
RA Kramer J., Fulton L., Mardis E., Dante M., Pepin K., Hillier L.W.,
RA Nelson J., Spieth J., Ryan E., Andrews S., Geisel C., Layman D., Du H.,
RA Ali J., Berghoff A., Jones K., Drone K., Cotton M., Joshu C., Antonoiu B.,
RA Zidanic M., Strong C., Sun H., Lamar B., Yordan C., Ma P., Zhong J.,
RA Preston R., Vil D., Shekher M., Matero A., Shah R., Swaby I.K.,
RA O'Shaughnessy A., Rodriguez M., Hoffman J., Till S., Granat S., Shohdy N.,
RA Hasegawa A., Hameed A., Lodhi M., Johnson A., Chen E., Marra M.A.,
RA Martienssen R., McCombie W.R.;
RT "Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana.";
RL Nature 402:769-777(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP GENE STRUCTURE.
RX PubMed=12671079; DOI=10.1105/tpc.009308;
RA Meyers B.C., Kozik A., Griego A., Kuang H., Michelmore R.W.;
RT "Genome-wide analysis of NBS-LRR-encoding genes in Arabidopsis.";
RL Plant Cell 15:809-834(2003).
CC -!- FUNCTION: Potential disease resistance protein. {ECO:0000250}.
CC -!- DOMAIN: The LRR repeats probably act as specificity determinant of
CC pathogen recognition. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the disease resistance NB-LRR family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAA16762.1; Type=Erroneous gene model prediction; Note=The predicted gene At4g19050 has been split into 2 genes: At4g19045 and At4g19050.; Evidence={ECO:0000305};
CC Sequence=CAB78907.1; Type=Erroneous gene model prediction; Note=The predicted gene At4g19050 has been split into 2 genes: At4g19045 and At4g19050.; Evidence={ECO:0000305};
CC -!- WEB RESOURCE: Name=NIB-LRRS; Note=Functional and comparative genomics
CC of disease resistance gene homologs;
CC URL="http://niblrrs.ucdavis.edu";
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DR EMBL; AL021711; CAA16762.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AL161550; CAB78907.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002687; AEE84134.1; -; Genomic_DNA.
DR PIR; T04426; T04426.
DR RefSeq; NP_193640.4; NM_118023.5.
DR AlphaFoldDB; P0CB16; -.
DR SMR; P0CB16; -.
DR BioGRID; 12936; 1.
DR STRING; 3702.P0CB16; -.
DR PaxDb; 3702-AT4G19050-1; -.
DR ProteomicsDB; 224322; -.
DR EnsemblPlants; AT4G19050.1; AT4G19050.1; AT4G19050.
DR GeneID; 827643; -.
DR Gramene; AT4G19050.1; AT4G19050.1; AT4G19050.
DR KEGG; ath:AT4G19050; -.
DR Araport; AT4G19050; -.
DR TAIR; AT4G19050; -.
DR eggNOG; KOG0440; Eukaryota.
DR HOGENOM; CLU_004092_0_0_1; -.
DR InParanoid; P0CB16; -.
DR OMA; WSQIKEC; -.
DR OrthoDB; 656428at2759; -.
DR PRO; PR:P0CB16; -.
DR Proteomes; UP000006548; Chromosome 4.
DR ExpressionAtlas; P0CB16; baseline and differential.
DR GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 4.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR002182; NB-ARC.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR45752; LEUCINE-RICH REPEAT-CONTAINING; 1.
DR PANTHER; PTHR45752:SF41; PLANT INTRACELLULAR RAS-GROUP-RELATED LRR PROTEIN 8; 1.
DR Pfam; PF00931; NB-ARC; 1.
DR PRINTS; PR00364; DISEASERSIST.
DR SUPFAM; SSF52058; L domain-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52047; RNI-like; 2.
PE 3: Inferred from homology;
KW ATP-binding; Leucine-rich repeat; Nucleotide-binding; Plant defense;
KW Reference proteome; Repeat.
FT CHAIN 1..1201
FT /note="Putative disease resistance protein At4g19050"
FT /id="PRO_0000212757"
FT REPEAT 469..491
FT /note="LRR 1"
FT REPEAT 492..514
FT /note="LRR 2"
FT REPEAT 517..539
FT /note="LRR 3"
FT REPEAT 540..562
FT /note="LRR 4"
FT REPEAT 680..701
FT /note="LRR 5"
FT REPEAT 703..725
FT /note="LRR 6"
FT REPEAT 726..748
FT /note="LRR 7"
FT REPEAT 750..771
FT /note="LRR 8"
FT REPEAT 773..795
FT /note="LRR 9"
FT REPEAT 796..818
FT /note="LRR 10"
FT REPEAT 820..841
FT /note="LRR 11"
FT REPEAT 843..865
FT /note="LRR 12"
FT REPEAT 866..888
FT /note="LRR 13"
FT REPEAT 890..911
FT /note="LRR 14"
FT REGION 1162..1201
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1162..1180
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1181..1201
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 33..40
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255"
SQ SEQUENCE 1201 AA; 136827 MW; 0108CC8A0F1121F9 CRC64;
MEKQDQTSRE EILKKIMDSL GQDGVPSKTV LVGEAGIGKT WLAKEVSQRV TQEKYNVLWL
HLNKKIEDEK SLYEILAAQL SIIYEFEEGE EPDELDYPLE SLKEKIKEEM IKHKKDNLLL
ILDDEGSMTT EEDVMQELNL QDFLKEYSAV KILVTRRDER EEKESTTIKV GPLTEKESLD
LLHDAEDLLT SFTSEDWPVL LKRLCDNKEI KEPTLMSCIL SKSKGLPAAI VVLIKSLNSI
KSMSAKQRKI FKELILSSKS LDEAAASKNA IDRSRYNPVL QLSYELLKPD ETVKRPVIAC
FWHILDFYKY SGCAYYRDLI VHWMLEGYFD PVKSVDKAYQ EGHSILMDFM NRGILKIQED
NMVVPEFSMS NLLDLQDCGF FGRSSLGFDR VYGGDKRKGL GKIILIDDMI QTIQSKKKNI
TTIIASGNRL RREVHGKFFE KPEMQDLEVV VLFEPTFHEL VLSLSKLKKL RVLVIRDCDL
IDNIDKLSGL QGLHVLEVSG ASSLVNIPDD FFKNMTQLQS LNLSGLAIKS SPSTIEKLSM
LRCFILRHCS ELQDLPNFIV ETRKLEVIDI HGARKLESYF DRVKDWKDYK GKNKNFAQLQ
LLEHLDFSET KIIRLPIFHL KDSTNDFSTM PILTRLLLRN CTRLKRLPQL RPLTNLQILD
ACGATDLVEM LEVCLEEKKE LRILDMSKTS LPELADTIAD VVNLNKLLLR NCSLIEELPS
IEKLTHLEVF DVSGCIKLKN INGSFGEMSY LHEVNLSETN LSELPDKISE LSNLKELIIR
KCSKLKTLPN LEKLTNLEIF DVSGCTELET IEGSFENLSC LHKVNLSETN LGELPNKISE
LSNLKELILR NCSKLKALPN LEKLTHLVIF DVSGCTNLDK IEESFESMSY LCEVNLSGTN
LKTFPELPKQ SILCSSKRIV LADSSCIERD QWSQIKECLT SKSEGSSFSN VGEKTREKLL
YHGNRYRVID PEVPLNIDIV DIKRSTDLKT EYIAKAEYVS IAENGSKSVS SLFDELQMAS
VKGCWVERCK NMDVLFESDE QLEKEKSSSP SLQTLWISNL PLLTSLYSSK GGFIFKNLKK
LSVDCCPSIK WLFPEIPDNL EILRVKFCDK LERLFEVKAG ELSKLRKLHL LDLPVLSVLG
ANFPNLEKCT IEKCPKLKAR EDEPRIGARI TDEISEDQPH KNTIGPETQT PTQPTKATDT
V
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