ID E0AAD2_9HIV1 Unreviewed; 180 AA.
AC E0AAD2;
DT 05-OCT-2010, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2010, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE SubName: Full=Pol protein {ECO:0000313|EMBL:ADK75430.1};
DE Flags: Fragment;
GN Name=pol {ECO:0000313|EMBL:ADK75430.1};
OS Human immunodeficiency virus 1.
OC Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC Ortervirales; Retroviridae; Orthoretrovirinae; Lentivirus.
OX NCBI_TaxID=11676 {ECO:0000313|EMBL:ADK75430.1};
OH NCBI_TaxID=9606; Homo sapiens (Human).
RN [1] {ECO:0000313|EMBL:ADK75430.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=MM47d57_PB1 {ECO:0000313|EMBL:ADK75430.1};
RX PubMed=19454710; DOI=10.4049/jimmunol.0803658;
RA Turnbull E.L., Wong M., Wang S., Wei X., Jones N.A., Conrod K.E., Aldam D.,
RA Turner J., Pellegrino P., Keele B.F., Williams I., Shaw G.M., Borrow P.;
RT "Kinetics of expansion of epitope-specific T cell responses during primary
RT HIV-1 infection.";
RL J. Immunol. 182:7131-7145(2009).
RN [2] {ECO:0000313|EMBL:ADK75430.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=MM47d57_PB1 {ECO:0000313|EMBL:ADK75430.1};
RA Wang S.;
RL Submitted (JUN-2010) to the EMBL/GenBank/DDBJ databases.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; HM586305; ADK75430.1; -; Genomic_DNA.
DR GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0003964; F:RNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0015074; P:DNA integration; IEA:UniProtKB-KW.
DR GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR GO; GO:0075713; P:establishment of integrated proviral latency; IEA:UniProtKB-KW.
DR GO; GO:0046718; P:viral entry into host cell; IEA:UniProtKB-KW.
DR GO; GO:0044826; P:viral genome integration into host DNA; IEA:UniProtKB-KW.
DR Gene3D; 1.10.10.200; -; 1.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR InterPro; IPR017856; Integrase-like_N.
DR InterPro; IPR001584; Integrase_cat-core.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR PANTHER; PTHR41694; ENDOGENOUS RETROVIRUS GROUP K MEMBER POL PROTEIN; 1.
DR PANTHER; PTHR41694:SF3; RNA-DIRECTED DNA POLYMERASE-RELATED; 1.
DR Pfam; PF00665; rve; 1.
DR SUPFAM; SSF46919; N-terminal Zn binding domain of HIV integrase; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR PROSITE; PS50994; INTEGRASE; 1.
PE 4: Predicted;
KW DNA integration {ECO:0000256|ARBA:ARBA00022908};
KW DNA recombination {ECO:0000256|ARBA:ARBA00023172};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022771};
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW Virus entry into host cell {ECO:0000256|ARBA:ARBA00023296};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 22..172
FT /note="Integrase catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50994"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ADK75430.1"
FT NON_TER 180
FT /evidence="ECO:0000313|EMBL:ADK75430.1"
SQ SEQUENCE 180 AA; 19696 MW; 982FC22B8A61ECF7 CRC64;
AKEIVASCDK CQLKGEAMHG QVDCSPGIWQ LDCTHLEGKI ILVAVHVASG YIEAEVIPTE
TGQETAYFIL KLAGRWPVKV IHTDNGSNFT SATVKAACWW AGIQQEFGIP YNPQSQGVVE
SMNNELKKII GQVRDQAEHL KTAVQMAVFI HNFKRKGGIG GYSAGERIID IIATDIQTKE
//
