ID E0CPH0_VITVI Unreviewed; 808 AA.
AC E0CPH0;
DT 05-OCT-2010, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2010, sequence version 1.
DT 27-MAR-2024, entry version 68.
DE RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
GN OrderedLocusNames=VIT_18s0001g13410 {ECO:0000313|EMBL:CBI19786.3};
OS Vitis vinifera (Grape).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; Vitales; Vitaceae; Viteae; Vitis.
OX NCBI_TaxID=29760 {ECO:0000313|EMBL:CBI19786.3, ECO:0000313|Proteomes:UP000009183};
RN [1] {ECO:0000313|Proteomes:UP000009183}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Pinot noir / PN40024 {ECO:0000313|Proteomes:UP000009183};
RX PubMed=17721507; DOI=10.1038/nature06148;
RG The French-Italian Public Consortium for Grapevine Genome Characterization.;
RA Jaillon O., Aury J.-M., Noel B., Policriti A., Clepet C., Casagrande A.,
RA Choisne N., Aubourg S., Vitulo N., Jubin C., Vezzi A., Legeai F.,
RA Hugueney P., Dasilva C., Horner D., Mica E., Jublot D., Poulain J.,
RA Bruyere C., Billault A., Segurens B., Gouyvenoux M., Ugarte E.,
RA Cattonaro F., Anthouard V., Vico V., Del Fabbro C., Alaux M.,
RA Di Gaspero G., Dumas V., Felice N., Paillard S., Juman I., Moroldo M.,
RA Scalabrin S., Canaguier A., Le Clainche I., Malacrida G., Durand E.,
RA Pesole G., Laucou V., Chatelet P., Merdinoglu D., Delledonne M.,
RA Pezzotti M., Lecharny A., Scarpelli C., Artiguenave F., Pe M.E., Valle G.,
RA Morgante M., Caboche M., Adam-Blondon A.-F., Weissenbach J., Quetier F.,
RA Wincker P.;
RT "The grapevine genome sequence suggests ancestral hexaploidization in major
RT angiosperm phyla.";
RL Nature 449:463-467(2007).
CC -!- FUNCTION: Essential component of the vacuolar proton pump (V-ATPase), a
CC multimeric enzyme that catalyzes the translocation of protons across
CC the membranes. Required for assembly and activity of the V-ATPase.
CC {ECO:0000256|RuleBase:RU361189}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC {ECO:0000256|ARBA:ARBA00009904, ECO:0000256|RuleBase:RU361189}.
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DR EMBL; FN595227; CBI19786.3; -; Genomic_DNA.
DR RefSeq; XP_010664756.1; XM_010666454.2.
DR AlphaFoldDB; E0CPH0; -.
DR STRING; 29760.E0CPH0; -.
DR PaxDb; 29760-VIT_18s0001g13410-t01; -.
DR EnsemblPlants; Vitvi18g01038_t001; Vitvi18g01038_P001; Vitvi18g01038.
DR GeneID; 100255659; -.
DR Gramene; Vitvi18g01038_t001; Vitvi18g01038_P001; Vitvi18g01038.
DR KEGG; vvi:100255659; -.
DR eggNOG; KOG2189; Eukaryota.
DR HOGENOM; CLU_005230_0_0_1; -.
DR InParanoid; E0CPH0; -.
DR OMA; VHFKRYS; -.
DR OrthoDB; 1967517at2759; -.
DR Proteomes; UP000009183; Chromosome 18.
DR ExpressionAtlas; E0CPH0; baseline and differential.
DR GO; GO:0016471; C:vacuolar proton-transporting V-type ATPase complex; IBA:GO_Central.
DR GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR GO; GO:0051117; F:ATPase binding; IBA:GO_Central.
DR GO; GO:0046961; F:proton-transporting ATPase activity, rotational mechanism; IEA:InterPro.
DR GO; GO:0007035; P:vacuolar acidification; IBA:GO_Central.
DR InterPro; IPR002490; V-ATPase_116kDa_su.
DR InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR PANTHER; PTHR11629:SF63; V-TYPE PROTON ATPASE SUBUNIT A; 1.
DR PANTHER; PTHR11629; VACUOLAR PROTON ATPASES; 1.
DR Pfam; PF01496; V_ATPase_I; 1.
DR PIRSF; PIRSF001293; ATP6V0A1; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Hydrogen ion transport {ECO:0000256|ARBA:ARBA00022781,
KW ECO:0000256|RuleBase:RU361189};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|RuleBase:RU361189};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361189};
KW Reference proteome {ECO:0000313|Proteomes:UP000009183};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU361189};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU361189};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU361189}.
FT TRANSMEM 404..435
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT TRANSMEM 456..474
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT TRANSMEM 537..555
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT TRANSMEM 567..590
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT TRANSMEM 626..644
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT TRANSMEM 745..766
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT COILED 83..124
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 808 AA; 92481 MW; CF3F03B43B66CFE9 CRC64;
MDLLRSEPMQ LVQLIIPVEA AYRTISYLGD LGLFQFKDLN AEKSPFQRTY ATQIKRCGEM
ARKLRFFKEQ MTKAGLSPST RSVARADFNL DDLEVQLAEF EAELTEIKAN NEKLQRAYSE
LVEYKLVLQK AGEFFYSAQN TAVAWQREVE AHHIGEGSID SPLLLEQEIL TDPSKQVKLG
FVSGLVPREK SMAFERILFR ATRGNVFLKQ ALVEDCVIDP VLGEKIEKNV FVIFFSGERV
KNKILKICDA FGANRYPFMD DLGKQYQMIT EVSRRLLELK TTVDAGLLHW SNLLQTIGHQ
FEQWNHLVKK EKSIYHTLNM LSIDVTKKCL VAEGWCPVFA TNQIQNALKQ ATFDSNSQLG
AIFQVLHTKE SPPTYFRTNK FTLPFQEIVD AYGVAKYQEV NPGVYVIITF PFLFAVMFGD
WGHGICLLLA TLYFIVKEKK FSSQKLGDIM EMTFGGRYVI MMMALFSIYT GLIYNEFFSV
PFELFGPSAY ECPDPSCRGA SIVGLIRVRP TYPFGVDPKW HGSRSELPFL NSLKMKMSIL
LGVAQMNLGI ILGYFNATFF GNNLNIWYQF VPQMIFLNSL FGYLSLLIIV KWCMGSQADL
YHVMIYMFLS PTDDLGENQL FVGQKMLQLV LLLLALVSIP WMLFPKPFLL KKQHQERHQG
RSYTLLHSID DSPELERHHD SLGHVEFEFS EVFVHQLIHT IEFVLGAVSN TASYLRLWAL
SLAHSELSSV FYEKVLLLAW GFNNVVILTI GIIVFIFATV GVLLVMETLS AFLHALRLHW
VEFQNKFYEG DGYKFYPFSF ALLTDEDA
//
