ID E0CYU0_MOUSE Unreviewed; 574 AA.
AC E0CYU0;
DT 05-OCT-2010, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2010, sequence version 1.
DT 27-MAR-2024, entry version 97.
DE SubName: Full=Spermatogenesis associated 13 {ECO:0000313|Ensembl:ENSMUSP00000123888.2};
GN Name=Spata13 {ECO:0000313|Ensembl:ENSMUSP00000123888.2,
GN ECO:0000313|MGI:MGI:104838};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000123888.2, ECO:0000313|Proteomes:UP000000589};
RN [1] {ECO:0000313|Ensembl:ENSMUSP00000123888.2, ECO:0000313|Proteomes:UP000000589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000123888.2,
RC ECO:0000313|Proteomes:UP000000589};
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2] {ECO:0000313|Ensembl:ENSMUSP00000123888.2}
RP IDENTIFICATION.
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000123888.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; NP_001297523.1; NM_001310594.1.
DR AlphaFoldDB; E0CYU0; -.
DR SMR; E0CYU0; -.
DR MaxQB; E0CYU0; -.
DR PeptideAtlas; E0CYU0; -.
DR ProteomicsDB; 345170; -.
DR Ensembl; ENSMUST00000162945.2; ENSMUSP00000123888.2; ENSMUSG00000021990.17.
DR GeneID; 219140; -.
DR KEGG; mmu:219140; -.
DR UCSC; uc007ufd.2; mouse.
DR AGR; MGI:104838; -.
DR CTD; 221178; -.
DR MGI; MGI:104838; Spata13.
DR VEuPathDB; HostDB:ENSMUSG00000021990; -.
DR GeneTree; ENSGT00940000154103; -.
DR HOGENOM; CLU_008436_2_0_1; -.
DR OMA; RERVGWF; -.
DR OrthoDB; 20491at2759; -.
DR BioGRID-ORCS; 219140; 1 hit in 75 CRISPR screens.
DR ChiTaRS; Spata13; mouse.
DR Proteomes; UP000000589; Chromosome 14.
DR Bgee; ENSMUSG00000021990; Expressed in vestibular membrane of cochlear duct and 251 other cell types or tissues.
DR ExpressionAtlas; E0CYU0; baseline and differential.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd01224; PH_Collybistin_ASEF; 1.
DR CDD; cd00160; RhoGEF; 1.
DR CDD; cd11973; SH3_ASEF; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR001331; GDS_CDC24_CS.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR47544; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 4; 1.
DR PANTHER; PTHR47544:SF2; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 9; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR Pfam; PF00018; SH3_1; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS00741; DH_1; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50002; SH3; 1.
PE 1: Evidence at protein level;
KW Proteomics identification {ECO:0007829|EPD:E0CYU0,
KW ECO:0007829|MaxQB:E0CYU0};
KW Reference proteome {ECO:0000313|Proteomes:UP000000589};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 69..128
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 162..346
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 377..483
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 133..160
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 136..159
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 574 AA; 66535 MW; CB414EE98BBEC0DC CRC64;
MVARGEIARF WSLESLHMVS SDGGAESSAL VDDNGSEEDF SYEELCQANP RYLQPGGEQL
AINELISDGS VVCAEALWDH VTMDDQELGF KAGDVIQVLE ASNKDWWWGR NEDKEAWFPA
SFVRLRVNQE ELPENCSSSH GEEQDEDTSK ARHKHPESQQ QMRTNVIQEI MNTERVYIKH
LKDICEGYIR QCRKHTGMFT VAQLATIFGN IEDIYKFQRK FLKDLEKQYN KEEPHLSEIG
SCFLEHQEGF AIYSEYCNNH PGACVELSNL MKHSKYRHFF EACRLLQQMI DIALDGFLLT
PVQKICKYPL QLAELLKYTT QEHGDYNNIK AAYEAMKNVA CLINERKRKL ESIDKIARWQ
VSIVGWEGLD ILDRSSELIH SGELTKITRQ GKSQQRIFFL FDHQLVSCKK DLLRRDMLYY
KGRMDMDEVE LVDVEDGRDK DWSLSLRNAF KLVSKATDEV HLFCARKQED KARWLQAYAD
ERRRVQEDQQ MGMEIPENQK KLAMLNAQKA GHGKSKGYNS CPVAPPHQSL PPLHQRHITV
PTSIPQQQVF ALAEPKRKPS IFWHTFHKLT PFRK
//
