ID E0D899_SALTM Unreviewed; 336 AA.
AC E0D899;
DT 02-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2010, sequence version 1.
DT 24-JAN-2024, entry version 30.
DE RecName: Full=Aminoglycoside (3'') (9) adenylyltransferase {ECO:0000256|ARBA:ARBA00035252};
DE EC=2.7.7.47 {ECO:0000256|ARBA:ARBA00035126};
OS Salmonella typhimurium.
OG Plasmid pYT1 {ECO:0000313|EMBL:BAJ15314.1}.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Salmonella.
OX NCBI_TaxID=90371 {ECO:0000313|EMBL:BAJ15314.1};
RN [1] {ECO:0000313|EMBL:BAJ15314.1}
RP NUCLEOTIDE SEQUENCE.
RC PLASMID=pYT1 {ECO:0000313|EMBL:BAJ15314.1};
RX PubMed=24155970; DOI=10.1371/journal.pone.0077644;
RA Tamamura Y., Tanaka K., Akiba M., Kanno T., Hatama S., Ishihara R.,
RA Uchida I.;
RT "Complete Nucleotide Sequences of Virulence-Resistance Plasmids Carried by
RT Emerging Multidrug-Resistant Salmonella enterica Serovar Typhimurium
RT Isolated from Cattle in Hokkaido, Japan.";
RL PLoS ONE 8:e77644-e77644(2013).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + streptomycin = 3''-O-adenylylstreptomycin + diphosphate;
CC Xref=Rhea:RHEA:20245, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019,
CC ChEBI:CHEBI:58007, ChEBI:CHEBI:58605; EC=2.7.7.47;
CC Evidence={ECO:0000256|ARBA:ARBA00035070};
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DR EMBL; AB576781; BAJ15314.1; -; Genomic_DNA.
DR RefSeq; YP_003864165.1; NC_014476.2.
DR AlphaFoldDB; E0D899; -.
DR SMR; E0D899; -.
DR GO; GO:0016779; F:nucleotidyltransferase activity; IEA:InterPro.
DR CDD; cd05403; NT_KNTase_like; 1.
DR Gene3D; 3.30.460.10; Beta Polymerase, domain 2; 1.
DR InterPro; IPR025184; AadA_C.
DR InterPro; IPR043519; NT_sf.
DR InterPro; IPR002934; Polymerase_NTP_transf_dom.
DR Pfam; PF13427; AadA_C; 1.
DR Pfam; PF01909; NTP_transf_2; 1.
DR SUPFAM; SSF81301; Nucleotidyltransferase; 1.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE 4: Predicted;
KW Plasmid {ECO:0000313|EMBL:BAJ15314.1}.
FT DOMAIN 101..147
FT /note="Polymerase nucleotidyl transferase"
FT /evidence="ECO:0000259|Pfam:PF01909"
FT DOMAIN 225..327
FT /note="Adenylyltransferase AadA C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13427"
SQ SEQUENCE 336 AA; 37523 MW; BBE0E996024B7D64 CRC64;
MRSRNWSRTL TERSGGNGAV AVFMACYDCF FGVQSMPRAS KQQARYAVGR CLMLWSSNDV
TQQGSRPKTK LNIMREAVIA EVSTQLSEVV GVIERHLEPT LLAVHLYGSA VDGGLKPHSD
IDLLVTVTVR LDETTRRALI NDLLETSASP GESEILRAVE VTIVVHDDII PWRYPAKREL
QFGEWQRNDI LAGIFEPATI DIDLAILLTK AREHSVALVG PAAEELFDPV PEQDLFEALN
ETLTLWNSPP DWAGDERNVV LTLSRIWYSA VTGKIAPKDV AADWAMERLP AQYQPVILEA
RQAYLGQEED RLASRADQLE EFVHYVKGEI TKVVGK
//
