ID E0PEJ9_STREI Unreviewed; 480 AA.
AC E0PEJ9;
DT 02-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2010, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE RecName: Full=Regulatory protein MsrR {ECO:0000256|ARBA:ARBA00040752};
GN Name=psr {ECO:0000313|EMBL:EFM27176.1};
GN ORFNames=HMPREF9319_1311 {ECO:0000313|EMBL:EFM27176.1};
OS Streptococcus equinus ATCC 700338.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
OC Streptococcus.
OX NCBI_TaxID=864569 {ECO:0000313|EMBL:EFM27176.1, ECO:0000313|Proteomes:UP000004290};
RN [1] {ECO:0000313|EMBL:EFM27176.1, ECO:0000313|Proteomes:UP000004290}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700338 {ECO:0000313|EMBL:EFM27176.1,
RC ECO:0000313|Proteomes:UP000004290};
RA Muzny D., Qin X., Deng J., Jiang H., Liu Y., Qu J., Song X.-Z., Zhang L.,
RA Thornton R., Coyle M., Francisco L., Jackson L., Javaid M., Korchina V.,
RA Kovar C., Mata R., Mathew T., Ngo R., Nguyen L., Nguyen N., Okwuonu G.,
RA Ongeri F., Pham C., Simmons D., Wilczek-Boney K., Hale W., Jakkamsetti A.,
RA Pham P., Ruth R., San Lucas F., Warren J., Zhang J., Zhao Z., Zhou C.,
RA Zhu D., Lee S., Bess C., Blankenburg K., Forbes L., Fu Q., Gubbala S.,
RA Hirani K., Jayaseelan J.C., Lara F., Munidasa M., Palculict T., Patil S.,
RA Pu L.-L., Saada N., Tang L., Weissenberger G., Zhu Y., Hemphill L.,
RA Shang Y., Youmans B., Ayvaz T., Ross M., Santibanez J., Aqrawi P.,
RA Gross S., Joshi V., Fowler G., Nazareth L., Reid J., Worley K.,
RA Petrosino J., Highlander S., Gibbs R.;
RL Submitted (JUL-2010) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Involved in SarA attenuation. Affects resistance to oxacillin
CC and teicoplanin, as well as the synthesis of virulence factors.
CC {ECO:0000256|ARBA:ARBA00037178}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004401};
CC Single-pass type II membrane protein {ECO:0000256|ARBA:ARBA00004401}.
CC -!- SIMILARITY: Belongs to the LytR/CpsA/Psr (LCP) family.
CC {ECO:0000256|ARBA:ARBA00006068}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EFM27176.1}.
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DR EMBL; AEEL01000016; EFM27176.1; -; Genomic_DNA.
DR RefSeq; WP_003065523.1; NZ_GL397128.1.
DR AlphaFoldDB; E0PEJ9; -.
DR GeneID; 76468272; -.
DR HOGENOM; CLU_016455_1_0_9; -.
DR Proteomes; UP000004290; Miscellaneous, Scaffold Scaffold1.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR Gene3D; 3.40.630.190; LCP protein; 1.
DR InterPro; IPR004474; LytR_CpsA_psr.
DR NCBIfam; TIGR00350; lytR_cpsA_psr; 1.
DR PANTHER; PTHR33392; POLYISOPRENYL-TEICHOIC ACID--PEPTIDOGLYCAN TEICHOIC ACID TRANSFERASE TAGU; 1.
DR PANTHER; PTHR33392:SF8; REGULATORY PROTEIN MSRR; 1.
DR Pfam; PF03816; LytR_cpsA_psr; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 152..172
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 221..397
FT /note="Cell envelope-related transcriptional attenuator"
FT /evidence="ECO:0000259|Pfam:PF03816"
FT REGION 81..106
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 90..104
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 480 AA; 54802 MW; C955D6E576B4B1C6 CRC64;
MARNNLSRHE ELRYEYLLKN LEYLSLREKQ EFNYLYNKKQ AGEVNEPPRS QPSSAYNDNY
YDDYYDDAYD NQVDYYDDDN WTSQGLPKYP EEKKQSKRSF RRTSEQQAEI LPTYQDNYEN
YNEAFYQESE PVTPKKAKKP KKKRRKIRIK HLLKLLGFLV ILVMAGMIYM FFKGVNDVSS
GETNYTAAVT ETFNGEDSDD GTNILILGSD QRVTQGSSDA RTDTIMVMNI GNSDGKIKLV
SFMRDTLVNI DGVSYNDYSN DQKLNVAFNI GEQDNNQGAE LMRQTLKDNF DINIKYYVMV
DFATFAEAID TLFPNGVEID AKFGTVDGQA VSSVEVPDDL NMQADGTVPN QTIEVRTQKM
DGRTLLNYAR FRKDDDGDYG RTQRQQQVIS AIINQIKDPT KLFTGSAAIG KIYALTSTNV
SYSFLLKEGL SVITSGQEGI EQTTIPAEGD WTDDYDMYGG LGIAIDFDKY QEELKELGLR
//
