ID E0PZB1_9STRE Unreviewed; 1558 AA.
AC E0PZB1;
DT 02-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2010, sequence version 1.
DT 27-MAR-2024, entry version 61.
DE SubName: Full=Putative cross-wall-targeting lipoprotein signal {ECO:0000313|EMBL:EFM36330.1};
GN ORFNames=HMPREF9189_0142 {ECO:0000313|EMBL:EFM36330.1};
OS Streptococcus sp. oral taxon 071 str. 73H25AP.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
OC Streptococcus.
OX NCBI_TaxID=864570 {ECO:0000313|EMBL:EFM36330.1, ECO:0000313|Proteomes:UP000005184};
RN [1] {ECO:0000313|EMBL:EFM36330.1, ECO:0000313|Proteomes:UP000005184}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=73H25AP {ECO:0000313|EMBL:EFM36330.1,
RC ECO:0000313|Proteomes:UP000005184};
RA Muzny D., Qin X., Deng J., Jiang H., Liu Y., Qu J., Song X.-Z., Zhang L.,
RA Thornton R., Coyle M., Francisco L., Jackson L., Javaid M., Korchina V.,
RA Kovar C., Mata R., Mathew T., Ngo R., Nguyen L., Nguyen N., Okwuonu G.,
RA Ongeri F., Pham C., Simmons D., Wilczek-Boney K., Hale W., Jakkamsetti A.,
RA Pham P., Ruth R., San Lucas F., Warren J., Zhang J., Zhao Z., Zhou C.,
RA Zhu D., Lee S., Bess C., Blankenburg K., Forbes L., Fu Q., Gubbala S.,
RA Hirani K., Jayaseelan J.C., Lara F., Munidasa M., Palculict T., Patil S.,
RA Pu L.-L., Saada N., Tang L., Weissenberger G., Zhu Y., Hemphill L.,
RA Shang Y., Youmans B., Ayvaz T., Ross M., Santibanez J., Aqrawi P.,
RA Gross S., Joshi V., Fowler G., Nazareth L., Reid J., Worley K.,
RA Petrosino J., Highlander S., Gibbs R.;
RL Submitted (AUG-2010) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the antigen I/II family.
CC {ECO:0000256|ARBA:ARBA00024351, ECO:0000256|PROSITE-ProRule:PRU01310}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EFM36330.1}.
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DR EMBL; AEEP01000004; EFM36330.1; -; Genomic_DNA.
DR RefSeq; WP_000791196.1; NZ_GL397254.1.
DR eggNOG; COG3064; Bacteria.
DR eggNOG; COG3087; Bacteria.
DR eggNOG; COG3266; Bacteria.
DR HOGENOM; CLU_257994_0_0_9; -.
DR Proteomes; UP000005184; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR Gene3D; 2.60.40.740; -; 3.
DR Gene3D; 6.10.250.2200; -; 5.
DR Gene3D; 2.60.530.10; Major cell-surface adhesin PAc; 1.
DR InterPro; IPR026345; Adh_isopep-form_adh_dom.
DR InterPro; IPR041324; AgI/II_N.
DR InterPro; IPR032300; Antigen_C.
DR InterPro; IPR021197; Cross-wall-target_lipo_motif.
DR InterPro; IPR013574; Glucan-bd_C/Surface_Ag-I/II_V.
DR InterPro; IPR019931; LPXTG_anchor.
DR InterPro; IPR036234; SA_I/II_PAC_V_sf.
DR InterPro; IPR009578; Surface_Ag_I_II_A_rpt.
DR NCBIfam; TIGR04228; isopep_sspB_C2; 1.
DR NCBIfam; TIGR01167; LPXTG_anchor; 1.
DR NCBIfam; NF033804; Streccoc_I_II; 1.
DR NCBIfam; TIGR03726; strep_RK_lipo; 1.
DR PANTHER; PTHR24216:SF65; PAXILLIN-LIKE PROTEIN 1; 1.
DR PANTHER; PTHR24216; PAXILLIN-RELATED; 1.
DR Pfam; PF18652; Adhesin_P1_N; 1.
DR Pfam; PF17998; AgI_II_C2; 1.
DR Pfam; PF16364; Antigen_C; 1.
DR Pfam; PF08363; GbpC; 1.
DR Pfam; PF00746; Gram_pos_anchor; 1.
DR Pfam; PF06696; Strep_SA_rep; 7.
DR PRINTS; PR01217; PRICHEXTENSN.
DR SUPFAM; SSF74914; V-region of surface antigen I/II (SA I/II, PAC); 1.
DR PROSITE; PS51965; AG_I_II_AR; 4.
DR PROSITE; PS50847; GRAM_POS_ANCHORING; 1.
PE 3: Inferred from homology;
KW Cell wall {ECO:0000256|ARBA:ARBA00022512};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Lipoprotein {ECO:0000313|EMBL:EFM36330.1};
KW Peptidoglycan-anchor {ECO:0000256|ARBA:ARBA00023088};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..32
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 33..1558
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5038476260"
FT REPEAT 146..220
FT /note="Ag I/II A"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01310"
FT REPEAT 221..315
FT /note="Ag I/II A"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01310"
FT REPEAT 316..397
FT /note="Ag I/II A"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01310"
FT REPEAT 398..479
FT /note="Ag I/II A"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01310"
FT DOMAIN 1522..1558
FT /note="Gram-positive cocci surface proteins LPxTG"
FT /evidence="ECO:0000259|PROSITE:PS50847"
FT REGION 44..63
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 836..992
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1492..1530
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 142..509
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 868..884
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 907..923
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 946..962
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 969..992
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1503..1517
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1558 AA; 171248 MW; 5DE7E779C9B8B7A3 CRC64;
MKNKKEVYGF RKSKVAKTLC GAVLGTALIA FADQAVFADE VTETKSTSTV EVATTGNPAT
NLPEAQGEMS QVAKESQAKA GSKDSALPVE VSSADLDKTV ADAKSAGVKV VQDETKDKGT
ATTATENAQK QDEIKSDYAK RAKEIKTTTE AYKKEVAAHQ AETDKINAEN KAADDKYQKD
LKNHQEEVEK INTANATAKA EYEAKLAQYQ KDLATVKKAN EDSQQDYQNK LSAYQTELAR
VQKANADAKE AYEKAVKENT AKNAYEKAVK ENTAKNAALQ AENEAIKQRN ETAKANYDAA
MKQYEADLAA IKKANEDNDA DYQAKLATYQ TELARVQKAN ADAKAAYEKA VEDNTAKNTA
IQAENEAIKQ RNETAKATYE AALKQYEADL AVVKKANEDS EADYQAKLAK YQTELARVQK
ANADAKAAYE KAVEDNKAKN AALKAENEEI KQRNATAKTD YEAKLAKYEA DLAKYRKELA
EYPAKLKAYE DEQAKIKAAL VELEKNKDQD GYLSKPSAQS LVYDLESKAQ LDLKTEGKLL
TAAAVDEAFK KDTVKYGKKN LQLDNLNVKN LENGATTSSV ELYGNIGDKS DWTTNVGNKT
EVKWGSVLLE RGQSVTATYT NLQNSYYNGK KISKIVYKYT VDPSSKFQNP SGKVWLGIFS
DPTLGVFASA YTGDVEKGTS IFIKNEFTFY DENDQPINFD NALLSVASLN RENNSIEMAK
DYTGNFIKIS GSSVGEKDGK IYATETLNFK QGQGGSRWTM YKNSQPGSGW DSSDAPNSWY
GAGAISMSGS TNRVTVGAIS ATLVVPSDPV MAVDTGKRPN IWYSLNGKIR AVNVPKITKE
KPTPPVAPTA PQAPTYETEK PLDPAPVAPS YENEPTPPVK TPDQPEPSKP EEPTYETEKP
LEPAPVAPSY ENEPTPPVKT PDQPEPSKPE EPTYETEKPL EPAPVAPSYE NEPTPPVKTP
DQPEPSKPEE PNYDPLPTPP VAPTPKQLPT PPAVPTVHFH YNRLFAQPQI NKEIKNEDGV
DIDRTLVAKQ SVVKFELKTE ALTAGRPKTT SFVLVDPLPT GYQFDLEATK AASKGFETSY
DKASHTVTFK ATDETLATYN ADLTKPVETL YPTVVGRVLN DGATYTNNFT LTVNDAYGVK
SNIVRVTTPG KPNDPDNPNN NYIKPLKVNK NKQGVNIDGK EVLAGSTNYY ELTWDLDQYK
GDKSSKEAIQ NGFYYVDDYP EEALTLQPEL VKIRDLEGNL VSGISVQQFD SLEAAPKKVQ
ELLKKANITV KGAFQLFSAD NPAEFYKNYV AAGKSLLITD PMTVKPEFGQ TGGKYENKAY
QIDFGNGYAT EVVVNNVPKI TPKKDVTISM DPSSDNIDGQ TIPLNQYFNY RLIGGLIPQN
HSEDLNDYSF VDDYDQKGDQ YTGNYKVLAK VDIRLKDGRV IKAGTDLTAE TQVEHDQDKG
MITIRFKEEF LQEIQLDSPF QAETYIQMKR IAVGTFENTY VNTVNKVAYA SNTVRTTTPE
PKKPEEPTTP NSNPNPKGNP TLPQTGTNDS SYMPYLGLAA LVGVLGLGQL KRKEDESN
//
