ID E0Q8W4_9BIFI Unreviewed; 647 AA.
AC E0Q8W4;
DT 02-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2010, sequence version 1.
DT 24-JAN-2024, entry version 43.
DE RecName: Full=biotin carboxylase {ECO:0000256|ARBA:ARBA00013263};
DE EC=6.3.4.14 {ECO:0000256|ARBA:ARBA00013263};
GN Name=accA {ECO:0000313|EMBL:EFM41256.1};
GN ORFNames=HMPREF0168_1572 {ECO:0000313|EMBL:EFM41256.1};
OS Bifidobacterium dentium ATCC 27679.
OC Bacteria; Actinomycetota; Actinomycetes; Bifidobacteriales;
OC Bifidobacteriaceae; Bifidobacterium.
OX NCBI_TaxID=871562 {ECO:0000313|EMBL:EFM41256.1, ECO:0000313|Proteomes:UP000003323};
RN [1] {ECO:0000313|EMBL:EFM41256.1, ECO:0000313|Proteomes:UP000003323}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 27679 {ECO:0000313|EMBL:EFM41256.1,
RC ECO:0000313|Proteomes:UP000003323};
RA Muzny D., Qin X., Deng J., Jiang H., Liu Y., Qu J., Song X.-Z., Zhang L.,
RA Thornton R., Coyle M., Francisco L., Jackson L., Javaid M., Korchina V.,
RA Kovar C., Mata R., Mathew T., Ngo R., Nguyen L., Nguyen N., Okwuonu G.,
RA Ongeri F., Pham C., Simmons D., Wilczek-Boney K., Hale W., Jakkamsetti A.,
RA Pham P., Ruth R., San Lucas F., Warren J., Zhang J., Zhao Z., Zhou C.,
RA Zhu D., Lee S., Bess C., Blankenburg K., Forbes L., Fu Q., Gubbala S.,
RA Hirani K., Jayaseelan J.C., Lara F., Munidasa M., Palculict T., Patil S.,
RA Pu L.-L., Saada N., Tang L., Weissenberger G., Zhu Y., Hemphill L.,
RA Shang Y., Youmans B., Ayvaz T., Ross M., Santibanez J., Aqrawi P.,
RA Gross S., Joshi V., Fowler G., Nazareth L., Reid J., Worley K.,
RA Petrosino J., Highlander S., Gibbs R.;
RL Submitted (AUG-2010) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=biotin; Xref=ChEBI:CHEBI:57586;
CC Evidence={ECO:0000256|ARBA:ARBA00001953};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EFM41256.1}.
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DR EMBL; AEEQ01000010; EFM41256.1; -; Genomic_DNA.
DR AlphaFoldDB; E0Q8W4; -.
DR HOGENOM; CLU_000395_3_1_11; -.
DR Proteomes; UP000003323; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004075; F:biotin carboxylase activity; IEA:UniProtKB-EC.
DR GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR CDD; cd06850; biotinyl_domain; 1.
DR Gene3D; 2.40.50.100; -; 1.
DR Gene3D; 3.30.470.20; ATP-grasp fold, B domain; 1.
DR InterPro; IPR011761; ATP-grasp.
DR InterPro; IPR005481; BC-like_N.
DR InterPro; IPR011764; Biotin_carboxylation_dom.
DR InterPro; IPR005482; Biotin_COase_C.
DR InterPro; IPR000089; Biotin_lipoyl.
DR InterPro; IPR005479; CbamoylP_synth_lsu-like_ATP-bd.
DR InterPro; IPR016185; PreATP-grasp_dom_sf.
DR InterPro; IPR011054; Rudment_hybrid_motif.
DR InterPro; IPR011053; Single_hybrid_motif.
DR PANTHER; PTHR18866; CARBOXYLASE:PYRUVATE/ACETYL-COA/PROPIONYL-COA CARBOXYLASE; 1.
DR PANTHER; PTHR18866:SF33; METHYLCROTONOYL-COA CARBOXYLASE SUBUNIT ALPHA, MITOCHONDRIAL-RELATED; 1.
DR Pfam; PF02785; Biotin_carb_C; 1.
DR Pfam; PF00289; Biotin_carb_N; 1.
DR Pfam; PF00364; Biotin_lipoyl; 1.
DR Pfam; PF02786; CPSase_L_D2; 1.
DR SMART; SM00878; Biotin_carb_C; 1.
DR SUPFAM; SSF56059; Glutathione synthetase ATP-binding domain-like; 1.
DR SUPFAM; SSF52440; PreATP-grasp domain; 1.
DR SUPFAM; SSF51246; Rudiment single hybrid motif; 1.
DR SUPFAM; SSF51230; Single hybrid motif; 1.
DR PROSITE; PS50975; ATP_GRASP; 1.
DR PROSITE; PS50979; BC; 1.
DR PROSITE; PS50968; BIOTINYL_LIPOYL; 1.
DR PROSITE; PS00867; CPSASE_2; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00409};
KW Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000313|EMBL:EFM41256.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00409}.
FT DOMAIN 31..471
FT /note="Biotin carboxylation"
FT /evidence="ECO:0000259|PROSITE:PS50979"
FT DOMAIN 150..345
FT /note="ATP-grasp"
FT /evidence="ECO:0000259|PROSITE:PS50975"
FT DOMAIN 557..632
FT /note="Lipoyl-binding"
FT /evidence="ECO:0000259|PROSITE:PS50968"
SQ SEQUENCE 647 AA; 70615 MW; C935DD2FD4D6ED3D CRC64;
MEPYKKTASL LWKTSVRAAA KASNVDNMPK NVNTLLVANR GEIALRVVRT AREMGIPTVA
VYAEQDRHAQ YVQMADDAYL LSGDTYKDTY LNEDLLIDIL HRSGADAVHP GYGFLSEVAS
FAQKVIDAGA TWVGPNPKAL VDLGDKITAR RVATFAKVPP VPGISHSISD MRLLLDFAHT
HGYPLMLKRT DGGGGRGITL VRNDDELRGF YMNHDALQGG DLNEYFVERF IDKGRHVETQ
CGRDTHGNFT VYSTRDCSVQ RRNQKLVEEA PAPFLPDTVM EQLARYSRNL FEAVGYVGLG
TCEFMVTEQG KVYFLEVNPR LQVEHTVSEE VCGLDLVREQ LTIANDGELT VEHPIRGHSF
ELRLTCEDPA KNLTPSSGTL TALRWPSGPG IRVDSGVLEG DTISPKFDSM MGKLVVTASD
RANAVARVRR ALEELNIEGV PTPVSLFERI FNDDEFTAEH GAAYDVSTKW LERKYLNKEA
ASSHGGQPAS LSGAADEGKD IESSETFVIE VNNHRVSLTV PTDIVANLTG SAKARDAKRA
IQPLRGQGLH HVKRGPQASE GQSGIIASPM QAVVTRINVA EGQEVAKGDL LVVLESMKME
NYVYAPVKGT VTKIFVGPAN GVEAGETLLT INVAGATPES KDEEAEQ
//
