ID E0S742_ENCIT Unreviewed; 508 AA.
AC E0S742;
DT 02-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2010, sequence version 1.
DT 24-JAN-2024, entry version 52.
DE SubName: Full=NADPH cytochrome P450 reductase {ECO:0000313|EMBL:ADM11470.1};
GN ORFNames=Eint_050210 {ECO:0000313|EMBL:ADM11470.1};
OS Encephalitozoon intestinalis (strain ATCC 50506) (Microsporidian parasite)
OS (Septata intestinalis).
OC Eukaryota; Fungi; Fungi incertae sedis; Microsporidia; Unikaryonidae;
OC Encephalitozoon.
OX NCBI_TaxID=876142 {ECO:0000313|EMBL:ADM11470.1, ECO:0000313|Proteomes:UP000002313};
RN [1] {ECO:0000313|EMBL:ADM11470.1, ECO:0000313|Proteomes:UP000002313}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 50506 {ECO:0000313|EMBL:ADM11470.1,
RC ECO:0000313|Proteomes:UP000002313};
RX PubMed=20865802; DOI=10.1038/ncomms1082;
RA Corradi N., Pombert J.-F., Farinelli L., Didier E.S., Keeling P.J.;
RT "The complete sequence of the smallest known nuclear genome from the
RT microsporidian Encephalitozoon intestinalis.";
RL Nat. Commun. 1:77-77(2010).
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CP001946; ADM11470.1; -; Genomic_DNA.
DR RefSeq; XP_003072830.1; XM_003072784.1.
DR AlphaFoldDB; E0S742; -.
DR GeneID; 9699142; -.
DR KEGG; ein:Eint_050210; -.
DR VEuPathDB; MicrosporidiaDB:Eint_050210; -.
DR HOGENOM; CLU_001570_17_6_1; -.
DR OrthoDB; 276396at2759; -.
DR Proteomes; UP000002313; Chromosome V.
DR GO; GO:0010181; F:FMN binding; IEA:InterPro.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR Gene3D; 3.40.50.360; -; 1.
DR Gene3D; 3.40.50.80; Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module; 1.
DR Gene3D; 2.40.30.10; Translation factors; 1.
DR InterPro; IPR017927; FAD-bd_FR_type.
DR InterPro; IPR001094; Flavdoxin-like.
DR InterPro; IPR008254; Flavodoxin/NO_synth.
DR InterPro; IPR029039; Flavoprotein-like_sf.
DR InterPro; IPR039261; FNR_nucleotide-bd.
DR InterPro; IPR023173; NADPH_Cyt_P450_Rdtase_alpha.
DR InterPro; IPR001433; OxRdtase_FAD/NAD-bd.
DR InterPro; IPR017938; Riboflavin_synthase-like_b-brl.
DR PANTHER; PTHR19384:SF10; NADPH-DEPENDENT DIFLAVIN OXIDOREDUCTASE 1; 1.
DR PANTHER; PTHR19384; NITRIC OXIDE SYNTHASE-RELATED; 1.
DR Pfam; PF00258; Flavodoxin_1; 1.
DR Pfam; PF00175; NAD_binding_1; 1.
DR PRINTS; PR00369; FLAVODOXIN.
DR SUPFAM; SSF52343; Ferredoxin reductase-like, C-terminal NADP-linked domain; 1.
DR SUPFAM; SSF52218; Flavoproteins; 1.
DR SUPFAM; SSF63380; Riboflavin synthase domain-like; 1.
DR PROSITE; PS51384; FAD_FR; 1.
DR PROSITE; PS50902; FLAVODOXIN_LIKE; 1.
PE 4: Predicted;
KW Flavoprotein {ECO:0000256|ARBA:ARBA00022630};
KW FMN {ECO:0000256|ARBA:ARBA00022643}.
FT DOMAIN 2..164
FT /note="Flavodoxin-like"
FT /evidence="ECO:0000259|PROSITE:PS50902"
FT DOMAIN 182..395
FT /note="FAD-binding FR-type"
FT /evidence="ECO:0000259|PROSITE:PS51384"
SQ SEQUENCE 508 AA; 59314 MW; AE5D16453349120F CRC64;
MIPILYGSQT GTSIYVSNLI ERALLYGYDP KTIYNLDCFF NSRDQENLSS VMEMDLFDIE
KILDIDFIIF VCSTHGDGTE PFNMTKFWSF LSNSDLPGNL LSHLNFAVFG LGDSSYEKFN
YCSKKLFNRL RMLGAKPVVR RGDGNAQDKE GFLSDLRPWL LELMAHFDPL KIKHIDILSL
KPEKYTSRLV GKRLLTPEGH FQKIIELVFE IPEYKEFSPG DCLSFCPENY NYKEFMKYNG
MEEDVDGISS SLMMKHSIDF NSQPHQPFFF ALRYFLDRKG GIEDEVLLKI EEIAQDYDLY
YEYIVKPKRT IFEVLQELRV KVDARFLKKF VPTIYPRFFS VTKKKGLYHV TVAVVNYKTI
LSQPRRGVCS EYLMGLSLND KVPIGIGRSN LYFGSNKLLF ICTGTGITLP RACINEFKDK
EIVVFYGFRY RDRDFLYSDE WNCKNVRMLT AASRDDKMYV QDVFNRNPIE DIDEYLIFVS
GNSRLNKEVR KLFQKLYGRT IAFQSETW
//
