ID E0VAV1_PEDHC Unreviewed; 813 AA.
AC E0VAV1;
DT 02-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2010, sequence version 1.
DT 27-MAR-2024, entry version 72.
DE SubName: Full=WD-repeat protein, putative {ECO:0000313|EMBL:EEB10507.1, ECO:0000313|EnsemblMetazoa:PHUM045070-PA};
GN Name=8232704 {ECO:0000313|EnsemblMetazoa:PHUM045070-PA};
GN ORFNames=Phum_PHUM045070 {ECO:0000313|EMBL:EEB10507.1};
OS Pediculus humanus subsp. corporis (Body louse).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Paraneoptera; Psocodea; Phthiraptera; Anoplura; Pediculidae;
OC Pediculus.
OX NCBI_TaxID=121224;
RN [1] {ECO:0000313|EMBL:EEB10507.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=USDA {ECO:0000313|EMBL:EEB10507.1};
RA Kirkness E., Hannick L., Hass B., Bruggner R., Lawson D., Bidwell S.,
RA Joardar V., Caler E., Walenz B., Inman J., Schobel S., Galinsky K.,
RA Amedeo P., Strausberg R.;
RT "Annotation of Pediculus humanus corporis strain USDA.";
RL Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:EEB10507.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=USDA {ECO:0000313|EMBL:EEB10507.1};
RG The Human Body Louse Genome Consortium;
RA Kirkness E., Walenz B., Hass B., Bruggner R., Strausberg R.;
RT "The genome of the human body louse.";
RL Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EnsemblMetazoa:PHUM045070-PA}
RP IDENTIFICATION.
RC STRAIN=USDA {ECO:0000313|EnsemblMetazoa:PHUM045070-PA};
RG EnsemblMetazoa;
RL Submitted (FEB-2021) to UniProtKB.
CC -!- FUNCTION: May modify the assembly dynamics of microtubules, such that
CC microtubules are slightly longer, but more dynamic.
CC {ECO:0000256|ARBA:ARBA00003210}.
CC -!- SIMILARITY: Belongs to the WD repeat EMAP family.
CC {ECO:0000256|ARBA:ARBA00006489}.
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DR EMBL; AAZO01000527; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; DS235016; EEB10507.1; -; Genomic_DNA.
DR RefSeq; XP_002423245.1; XM_002423200.1.
DR AlphaFoldDB; E0VAV1; -.
DR STRING; 121224.E0VAV1; -.
DR EnsemblMetazoa; PHUM045070-RA; PHUM045070-PA; PHUM045070.
DR GeneID; 8232704; -.
DR KEGG; phu:Phum_PHUM045070; -.
DR CTD; 8232704; -.
DR VEuPathDB; VectorBase:PHUM045070; -.
DR eggNOG; KOG2106; Eukaryota.
DR HOGENOM; CLU_011754_1_0_1; -.
DR InParanoid; E0VAV1; -.
DR OMA; LHPSREM; -.
DR OrthoDB; 2959353at2759; -.
DR Proteomes; UP000009046; Unassembled WGS sequence.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR Gene3D; 3.10.20.230; Doublecortin domain; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR InterPro; IPR024977; Apc4-like_WD40_dom.
DR InterPro; IPR003533; Doublecortin_dom.
DR InterPro; IPR036572; Doublecortin_dom_sf.
DR InterPro; IPR005108; HELP.
DR InterPro; IPR011047; Quinoprotein_ADH-like_supfam.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR13720:SF55; ECHINODERM MICROTUBULE-ASSOCIATED PROTEIN-LIKE CG42247; 1.
DR PANTHER; PTHR13720; WD-40 REPEAT PROTEIN; 1.
DR Pfam; PF12894; ANAPC4_WD40; 1.
DR Pfam; PF03451; HELP; 1.
DR SMART; SM00320; WD40; 8.
DR SUPFAM; SSF89837; Doublecortin (DC); 1.
DR SUPFAM; SSF50998; Quinoprotein alcohol dehydrogenase-like; 1.
DR PROSITE; PS50309; DC; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 1.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000009046};
KW WD repeat {ECO:0000256|PROSITE-ProRule:PRU00221}.
FT DOMAIN 58..140
FT /note="Doublecortin"
FT /evidence="ECO:0000259|PROSITE:PS50309"
FT REPEAT 536..567
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REGION 13..58
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 140..179
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 13..38
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 140..165
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 813 AA; 91382 MW; 8F0FC9590D5593D4 CRC64;
MFLLNASYGK KNGTWSSGQS TTPIHQNQGW SKPSLSRKQS LGDGDLPPPG GGKPSSGRVI
RIVNNLDHTV QCRVLLNLRT TQPFEEVLED LGQVLKMNGA KRMYTVSGQE VRSFSQLRNE
FADVDTFYLG SGHYRQYERG FSPRRSRSRA ALSDELREPH SRSVSRSRSK SQPRAIYDSE
TIRGNVMKED PIRVTIRGMK RTFYPPIHHA PQDNTPPDKR LSLSWVFGYR GVDSRKNLWV
LPSGELLYFV AAVAVLYDRD EDSQRHYVGH TEDIQCMELH PSREMVASGQ RGGKNRKTQA
HIRIWSTETL LTLYVFGMGE FDVGVSAVSF SQLNGGSYVL AVDAGRERIM SVWQWQWGHL
LGKVATLQDE LTGAVFHPLD DNLLITHGKG NLTFWIRRKD GFFERTDIIK PPSRTNVTSV
QFEQDGDVVT ADSDGFITIY SVDADGAYFA HNKGIGSLIM LSEGTLLSGG EKDRRIIAWD
SLQNYKKVTE AKVANLNRVR SIYPQRPGRN DGNIYIGTTK NNILEGSLQR RFNQVVFGHG
RQLWGLAVHP DDELFATAGH DKNIALWRRN KLIWTIQVQY ECVSLSFHPF GSALATGSTE
GHLIILNAEN GTLITTVRVC GSPLTCVSYS PSGDTIGIGS QNGTIYLFRV SRDGFSYKKQ
NKIRGNQPII QLDWSSDGNY LQTTTSDYDL LYWDTKALIA EKSPITMKDV KWYTQTCTTG
YTVSGIWNNR YYPMASLIIT LNRSSAHDLL VTGDADGYLR LFRYPCLSPK AEYTEEKVYS
LQVGCARFLF NDKNVVTVGG TDAALMLWDV IDE
//
