ID E0VB86_PEDHC Unreviewed; 1158 AA.
AC E0VB86;
DT 02-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2010, sequence version 1.
DT 27-MAR-2024, entry version 76.
DE SubName: Full=Transient receptor potential protein, putative {ECO:0000313|EMBL:EEB10642.1, ECO:0000313|EnsemblMetazoa:PHUM055080-PA};
GN Name=8239031 {ECO:0000313|EnsemblMetazoa:PHUM055080-PA};
GN ORFNames=Phum_PHUM055080 {ECO:0000313|EMBL:EEB10642.1};
OS Pediculus humanus subsp. corporis (Body louse).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Paraneoptera; Psocodea; Phthiraptera; Anoplura; Pediculidae;
OC Pediculus.
OX NCBI_TaxID=121224;
RN [1] {ECO:0000313|EMBL:EEB10642.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=USDA {ECO:0000313|EMBL:EEB10642.1};
RA Kirkness E., Hannick L., Hass B., Bruggner R., Lawson D., Bidwell S.,
RA Joardar V., Caler E., Walenz B., Inman J., Schobel S., Galinsky K.,
RA Amedeo P., Strausberg R.;
RT "Annotation of Pediculus humanus corporis strain USDA.";
RL Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:EEB10642.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=USDA {ECO:0000313|EMBL:EEB10642.1};
RG The Human Body Louse Genome Consortium;
RA Kirkness E., Walenz B., Hass B., Bruggner R., Strausberg R.;
RT "The genome of the human body louse.";
RL Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EnsemblMetazoa:PHUM055080-PA}
RP IDENTIFICATION.
RC STRAIN=USDA {ECO:0000313|EnsemblMetazoa:PHUM055080-PA};
RG EnsemblMetazoa;
RL Submitted (FEB-2021) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; AAZO01000650; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; DS235023; EEB10642.1; -; Genomic_DNA.
DR RefSeq; XP_002423380.1; XM_002423335.1.
DR AlphaFoldDB; E0VB86; -.
DR STRING; 121224.E0VB86; -.
DR EnsemblMetazoa; PHUM055080-RA; PHUM055080-PA; PHUM055080.
DR GeneID; 8239031; -.
DR KEGG; phu:Phum_PHUM055080; -.
DR CTD; 8239031; -.
DR VEuPathDB; VectorBase:PHUM055080; -.
DR eggNOG; KOG3609; Eukaryota.
DR HOGENOM; CLU_005716_0_0_1; -.
DR InParanoid; E0VB86; -.
DR OMA; NEGLQMD; -.
DR OrthoDB; 5406916at2759; -.
DR Proteomes; UP000009046; Unassembled WGS sequence.
DR GO; GO:0034703; C:cation channel complex; IEA:UniProt.
DR GO; GO:0005262; F:calcium channel activity; IEA:InterPro.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR013555; TRP_dom.
DR InterPro; IPR002153; TRPC_channel.
DR NCBIfam; TIGR00870; trp; 1.
DR PANTHER; PTHR10117; TRANSIENT RECEPTOR POTENTIAL CHANNEL; 1.
DR PANTHER; PTHR10117:SF51; TRANSIENT RECEPTOR POTENTIAL PROTEIN; 1.
DR Pfam; PF00023; Ank; 1.
DR Pfam; PF12796; Ank_2; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR Pfam; PF08344; TRP_2; 1.
DR PRINTS; PR01097; TRNSRECEPTRP.
DR SMART; SM00248; ANK; 2.
DR SMART; SM01420; TRP_2; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 1.
DR PROSITE; PS50088; ANK_REPEAT; 1.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|ARBA:ARBA00023043, ECO:0000256|PROSITE-
KW ProRule:PRU00023}; Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000313|EMBL:EEB10642.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000009046};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 341..358
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 370..391
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 463..487
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 515..533
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 554..576
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 617..635
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 642..667
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REPEAT 149..181
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 184..246
FT /note="Transient receptor ion channel"
FT /evidence="ECO:0000259|SMART:SM01420"
FT REGION 962..995
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1088..1158
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 962..978
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 979..995
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1097..1111
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1113..1129
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1130..1144
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1158 AA; 133123 MW; 02EEDA29F0305AF4 CRC64;
MKVTESREEL FKKSIEDLED SCDYNLSALA ETFLTPTEKK FLLCAEKGDI PTLRSLLIQF
EDRPDELNIN CTDSLRRSAL VTAIENENMD LIKFLLKSNI KVKDALLHAI KEEFVEAVEV
LLEWEEKIHV DGEPYSWEAV DSASATFTPD ITPLILAAHT NNYEILKILL DRGATLPRPH
NVRCGCDECL ASSEADSLRH SQARINAYKA LSSSSLISLS SRDPLLTAFE LSWELKNLSY
CEAEYRSEYN EMRQATQDFA TALLDHARTS GELEVMLNYN PNGDIWEPGE RHTLERLKLA
IKYKQKKFVA HPNVQQLLAS IWYDGLPGFR RKSTVRQITD VLKLACLFPF YSCIYMIAPN
SKMGLFVKKP FVKFIFHSSS YAFFLLLLGL ASQRAENTFL ELLAMEIEWL HDVLAEWKRK
ERGSWPGVVE SALYLYIISL IYSEVRALWT NGLKEYMADL WNIVDFITNC FYLVWIGLRF
TAIYIVMRES NLGLDPYIPR EQWHPFDPML LSEGAFAGGM ILSFLKLVHV FSVNPHLGPL
QISLGRMIID ILKFFFIYML VLVAFGCGIN QLLWYYSNLE KVKCFGEDGT LEPDFDNNEK
ACTVWRRFAN LFETSQSLFW ASFGLVDLTS FDLVGINSFT RFWSLLLFGC YSVINIIVLL
NMLIAMMSNS YQIISERSDI EWKFARSHLW MSYFDDGDTL PPPFNLLPTM KTLLRIFKTE
KNLTADSFKV KSMDKARKRH ELVMNNLIAR YVTAEQRKRC DYGITEDDVI EIRQDISSLR
YELVHILRAN GMKTPEMNPD QNLVTKKGKI MERRLEKDFR IGIVEGIIHE FLSSDKDSLD
IFGKIAKVFN RKRNKSKKQD WNTIVRKSSY QKNLIGSSEE RRERLAKQSV RRYIIEKLSS
SEALDPEKLV QYNPQLLQMA PAARIAYTKF SRIKITREFA EQEKIINEEI EEEKHAEELV
KLTHSSTERK KDEEQPPNDT TDFSIVRPRP QSRSNSKLMK LISIPSKEGT ETKDCIIKMS
EEDENETIVT VENEIKQEKK TSSISIQSPP SLNDVIPTVV SIESPLKDVK KFEPVAAIIR
QMSIKSITTS PVQKSPPTDE MTPPTPPIPI IKKPEMKTDE NEENNKFTSL DIKGSRSPLA
DSSRGRSKVT GEIISGWL
//
