ID E0VGN6_PEDHC Unreviewed; 465 AA.
AC E0VGN6;
DT 02-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2010, sequence version 1.
DT 27-MAR-2024, entry version 61.
DE SubName: Full=6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase, putative {ECO:0000313|EMBL:EEB12542.1};
DE EC=3.1.3.46 {ECO:0000313|EMBL:EEB12542.1};
GN Name=8240065 {ECO:0000313|EnsemblMetazoa:PHUM189880-PA};
GN ORFNames=Phum_PHUM189880 {ECO:0000313|EMBL:EEB12542.1};
OS Pediculus humanus subsp. corporis (Body louse).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Paraneoptera; Psocodea; Phthiraptera; Anoplura; Pediculidae;
OC Pediculus.
OX NCBI_TaxID=121224;
RN [1] {ECO:0000313|EMBL:EEB12542.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=USDA {ECO:0000313|EMBL:EEB12542.1};
RA Kirkness E., Hannick L., Hass B., Bruggner R., Lawson D., Bidwell S.,
RA Joardar V., Caler E., Walenz B., Inman J., Schobel S., Galinsky K.,
RA Amedeo P., Strausberg R.;
RT "Annotation of Pediculus humanus corporis strain USDA.";
RL Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:EEB12542.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=USDA {ECO:0000313|EMBL:EEB12542.1};
RG The Human Body Louse Genome Consortium;
RA Kirkness E., Walenz B., Hass B., Bruggner R., Strausberg R.;
RT "The genome of the human body louse.";
RL Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EnsemblMetazoa:PHUM189880-PA}
RP IDENTIFICATION.
RC STRAIN=USDA {ECO:0000313|EnsemblMetazoa:PHUM189880-PA};
RG EnsemblMetazoa;
RL Submitted (FEB-2021) to UniProtKB.
CC -!- SIMILARITY: In the C-terminal section; belongs to the phosphoglycerate
CC mutase family. {ECO:0000256|ARBA:ARBA00008408}.
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DR EMBL; AAZO01002204; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; DS235150; EEB12542.1; -; Genomic_DNA.
DR RefSeq; XP_002425280.1; XM_002425235.1.
DR AlphaFoldDB; E0VGN6; -.
DR STRING; 121224.E0VGN6; -.
DR EnsemblMetazoa; PHUM189880-RA; PHUM189880-PA; PHUM189880.
DR GeneID; 8240065; -.
DR KEGG; phu:Phum_PHUM189880; -.
DR CTD; 8240065; -.
DR VEuPathDB; VectorBase:PHUM189880; -.
DR eggNOG; KOG0234; Eukaryota.
DR HOGENOM; CLU_006383_1_2_1; -.
DR InParanoid; E0VGN6; -.
DR OrthoDB; 2013830at2759; -.
DR Proteomes; UP000009046; Unassembled WGS sequence.
DR GO; GO:0003873; F:6-phosphofructo-2-kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004331; F:fructose-2,6-bisphosphate 2-phosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0006003; P:fructose 2,6-bisphosphate metabolic process; IEA:InterPro.
DR GO; GO:0006000; P:fructose metabolic process; IEA:InterPro.
DR CDD; cd07067; HP_PGM_like; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.40.50.1240; Phosphoglycerate mutase-like; 1.
DR InterPro; IPR003094; 6Pfruct_kin.
DR InterPro; IPR013079; 6Phosfructo_kin.
DR InterPro; IPR013078; His_Pase_superF_clade-1.
DR InterPro; IPR029033; His_PPase_superfam.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR10606; 6-PHOSPHOFRUCTO-2-KINASE/FRUCTOSE-2,6-BISPHOSPHATASE; 1.
DR PANTHER; PTHR10606:SF65; 6-PHOSPHOFRUCTO-2-KINASE_FRUCTOSE-2, 6-BISPHOSPHATASE-LIKE PROTEIN; 1.
DR Pfam; PF01591; 6PF2K; 1.
DR Pfam; PF00300; His_Phos_1; 1.
DR PIRSF; PIRSF000709; 6PFK_2-Ptase; 1.
DR PRINTS; PR00991; 6PFRUCTKNASE.
DR SMART; SM00855; PGAM; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF53254; Phosphoglycerate mutase-like; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Hydrolase {ECO:0000313|EMBL:EEB12542.1};
KW Kinase {ECO:0000313|EMBL:EEB12542.1};
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000009046};
KW Transferase {ECO:0000313|EMBL:EEB12542.1}.
FT DOMAIN 7..217
FT /note="6-phosphofructo-2-kinase"
FT /evidence="ECO:0000259|Pfam:PF01591"
FT COILED 149..176
FT /evidence="ECO:0000256|SAM:Coils"
FT ACT_SITE 225
FT /note="Tele-phosphohistidine intermediate"
FT /evidence="ECO:0000256|PIRSR:PIRSR613078-1"
FT ACT_SITE 294
FT /note="Proton donor/acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR613078-1"
FT BINDING 224..231
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR613078-2"
FT BINDING 274
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR613078-2"
SQ SEQUENCE 465 AA; 54257 MW; 3EF7A99797B49D23 CRC64;
MKFNDFRSLV VAFVGLPARG KTVLAHKLTR YLQWIGISTE VFSVCDYCRK HVELYDHNVF
RVDNREAMKL REKSTFEAME DATRWLKGDG KVAILDGTNP NRNYRKVLHE YFVKQLGYKL
LFVECICDDD GILEKNIREI LQFNIDYKKM KKEMAMKDLR CKIEHFKEQY ECLTTRNESN
LSFIKVFNGG ENISINKISG QLQCKILYYI SNFRAQPRTL YFSRHGESEF NLLGRIGGDA
NLSPRGLQYA QNLARYFNQR CIKGLKIWTS EKRRTNQTAG GILAPVESLE SLNELDAGIC
EGLTYDEMKE HYPKEFAWRD EDKLRYRYPW GESYVDIMTR TEPILMQLES EDNVLVLSHQ
AVLRCIIGYF LYKTKEQLPY LEIPLHTIIK LTSHGYDYKM ELIKLNVDCV DTTRKRPKDC
SLSTQQPSHE SLKNPVVTSH FHGNVKKFWS QDDNNNNNSN VCLGA
//