ID E0VJ88_PEDHC Unreviewed; 367 AA.
AC E0VJ88;
DT 02-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2010, sequence version 1.
DT 24-JAN-2024, entry version 63.
DE SubName: Full=Rhomboid-like protein {ECO:0000313|EnsemblMetazoa:PHUM240580-PA};
GN Name=8230716 {ECO:0000313|EnsemblMetazoa:PHUM240580-PA};
GN ORFNames=Phum_PHUM240580 {ECO:0000313|EMBL:EEB13444.1};
OS Pediculus humanus subsp. corporis (Body louse).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Paraneoptera; Psocodea; Phthiraptera; Anoplura; Pediculidae;
OC Pediculus.
OX NCBI_TaxID=121224;
RN [1] {ECO:0000313|EMBL:EEB13444.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=USDA {ECO:0000313|EMBL:EEB13444.1};
RA Kirkness E., Hannick L., Hass B., Bruggner R., Lawson D., Bidwell S.,
RA Joardar V., Caler E., Walenz B., Inman J., Schobel S., Galinsky K.,
RA Amedeo P., Strausberg R.;
RT "Annotation of Pediculus humanus corporis strain USDA.";
RL Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:EEB13444.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=USDA {ECO:0000313|EMBL:EEB13444.1};
RG The Human Body Louse Genome Consortium;
RA Kirkness E., Walenz B., Hass B., Bruggner R., Strausberg R.;
RT "The genome of the human body louse.";
RL Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EnsemblMetazoa:PHUM240580-PA}
RP IDENTIFICATION.
RC STRAIN=USDA {ECO:0000313|EnsemblMetazoa:PHUM240580-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the peptidase S54 family.
CC {ECO:0000256|ARBA:ARBA00009045}.
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DR EMBL; AAZO01002789; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; DS235221; EEB13444.1; -; Genomic_DNA.
DR RefSeq; XP_002426182.1; XM_002426137.1.
DR AlphaFoldDB; E0VJ88; -.
DR MEROPS; S54.012; -.
DR EnsemblMetazoa; PHUM240580-RA; PHUM240580-PA; PHUM240580.
DR GeneID; 8230716; -.
DR KEGG; phu:Phum_PHUM240580; -.
DR CTD; 8230716; -.
DR VEuPathDB; VectorBase:PHUM240580; -.
DR eggNOG; KOG2289; Eukaryota.
DR HOGENOM; CLU_048023_1_0_1; -.
DR InParanoid; E0VJ88; -.
DR OMA; ASIIMNW; -.
DR OrthoDB; 2872779at2759; -.
DR Proteomes; UP000009046; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR CDD; cd00051; EFh; 1.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR Gene3D; 1.20.1540.10; Rhomboid-like; 1.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR022764; Peptidase_S54_rhomboid_dom.
DR InterPro; IPR035952; Rhomboid-like_sf.
DR PANTHER; PTHR45840:SF8; RHOMBOID PROTEASE; 1.
DR PANTHER; PTHR45840; RHOMBOID-RELATED PROTEIN; 1.
DR Pfam; PF13499; EF-hand_7; 1.
DR Pfam; PF01694; Rhomboid; 1.
DR SMART; SM00054; EFh; 2.
DR SUPFAM; SSF47473; EF-hand; 1.
DR SUPFAM; SSF144091; Rhomboid-like; 1.
DR PROSITE; PS00018; EF_HAND_1; 2.
DR PROSITE; PS50222; EF_HAND_2; 2.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000009046};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 185..206
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 218..237
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 243..265
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 272..293
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 305..324
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 336..357
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 17..52
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT DOMAIN 53..88
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
SQ SEQUENCE 367 AA; 42064 MW; 0427EC84A9F93E66 CRC64;
MRFQEKNDLL SYLIMLQKLP KWVEIFNKFD KNRDGKISFK ELKKRIKEYN SEIPASTIRS
ILKKADTDED GVLDLNEFLA LVKSSREARG LFSNSLDKWV QTVCVVPKKG ICAEYTGDVT
DAEIEYEEHY SCCPPPLFMI IITVLELFAY IYDSIDQKPG QPSTTTILAS LFIYNPHRRA
EAWRYLTYMF VHIGIFHLLV NLLVQIMLGI PLEMVHHWWR VLFVYLAGVV AGSLATSVSD
PSIYLAGASG GVYAIMAAHV ASIIMNWTEK RFAWVQLLIF IILAITDVGT AIYNRYILDV
NDQVGYVAHL AGAVAGLLVG INVLRNFRVR TWEKTLRWFS FFFYSVLMLI AIIWNAAFPS
YFPKQRV
//
