ID E0VKU5_PEDHC Unreviewed; 745 AA.
AC E0VKU5;
DT 02-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2010, sequence version 1.
DT 24-JAN-2024, entry version 62.
DE SubName: Full=Calpain A, putative {ECO:0000313|EMBL:EEB14001.1, ECO:0000313|EnsemblMetazoa:PHUM269250-PA};
DE EC=3.4.22.52 {ECO:0000313|EMBL:EEB14001.1};
GN Name=8238947 {ECO:0000313|EnsemblMetazoa:PHUM269250-PA};
GN ORFNames=Phum_PHUM269250 {ECO:0000313|EMBL:EEB14001.1};
OS Pediculus humanus subsp. corporis (Body louse).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Paraneoptera; Psocodea; Phthiraptera; Anoplura; Pediculidae;
OC Pediculus.
OX NCBI_TaxID=121224;
RN [1] {ECO:0000313|EMBL:EEB14001.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=USDA {ECO:0000313|EMBL:EEB14001.1};
RA Kirkness E., Hannick L., Hass B., Bruggner R., Lawson D., Bidwell S.,
RA Joardar V., Caler E., Walenz B., Inman J., Schobel S., Galinsky K.,
RA Amedeo P., Strausberg R.;
RT "Annotation of Pediculus humanus corporis strain USDA.";
RL Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:EEB14001.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=USDA {ECO:0000313|EMBL:EEB14001.1};
RG The Human Body Louse Genome Consortium;
RA Kirkness E., Walenz B., Hass B., Bruggner R., Strausberg R.;
RT "The genome of the human body louse.";
RL Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EnsemblMetazoa:PHUM269250-PA}
RP IDENTIFICATION.
RC STRAIN=USDA {ECO:0000313|EnsemblMetazoa:PHUM269250-PA};
RG EnsemblMetazoa;
RL Submitted (FEB-2021) to UniProtKB.
CC -!- SIMILARITY: Belongs to the peptidase C2 family.
CC {ECO:0000256|ARBA:ARBA00007623}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00239}.
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DR EMBL; AAZO01003108; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; DS235250; EEB14001.1; -; Genomic_DNA.
DR RefSeq; XP_002426739.1; XM_002426694.1.
DR AlphaFoldDB; E0VKU5; -.
DR STRING; 121224.E0VKU5; -.
DR MEROPS; C02.023; -.
DR EnsemblMetazoa; PHUM269250-RA; PHUM269250-PA; PHUM269250.
DR GeneID; 8238947; -.
DR KEGG; phu:Phum_PHUM269250; -.
DR CTD; 8238947; -.
DR VEuPathDB; VectorBase:PHUM269250; -.
DR eggNOG; KOG0045; Eukaryota.
DR HOGENOM; CLU_010982_0_4_1; -.
DR InParanoid; E0VKU5; -.
DR OMA; FHIQIPR; -.
DR OrthoDB; 2962751at2759; -.
DR Proteomes; UP000009046; Unassembled WGS sequence.
DR GO; GO:0004198; F:calcium-dependent cysteine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR CDD; cd00044; CysPc; 1.
DR Gene3D; 2.60.120.380; -; 1.
DR Gene3D; 3.90.70.10; Cysteine proteinases; 1.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR InterPro; IPR022684; Calpain_cysteine_protease.
DR InterPro; IPR022682; Calpain_domain_III.
DR InterPro; IPR022683; Calpain_III.
DR InterPro; IPR036213; Calpain_III_sf.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR001300; Peptidase_C2_calpain_cat.
DR PANTHER; PTHR10183; CALPAIN; 1.
DR PANTHER; PTHR10183:SF424; CALPAIN-B-LIKE PROTEIN; 1.
DR Pfam; PF01067; Calpain_III; 1.
DR Pfam; PF00648; Peptidase_C2; 1.
DR PRINTS; PR00704; CALPAIN.
DR SMART; SM00720; calpain_III; 1.
DR SMART; SM00230; CysPc; 1.
DR SUPFAM; SSF49758; Calpain large subunit, middle domain (domain III); 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR SUPFAM; SSF47473; EF-hand; 1.
DR PROSITE; PS50203; CALPAIN_CAT; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000313|EMBL:EEB14001.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000009046}.
FT DOMAIN 95..399
FT /note="Calpain catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50203"
FT ACT_SITE 340
FT /evidence="ECO:0000256|PIRSR:PIRSR622684-1"
SQ SEQUENCE 745 AA; 86008 MW; F3133C74FFE95CAF CRC64;
MKCCKSELDL SSCRTMHQPS IGWNNVNGNI NQLGGKPNGH FQNGLTSRPW SNGILPRADD
KQSTLSRYWT VERPRNGKIN SYHAVKRSCR ERGILFEDAS FPPNNRSLSL HKKLPLQPII
WARPHELCQR PKFTVENCSD NLENSRFDIE VGELGDVWLL AAISSLTLTP RFLERVVPPD
QSFDSNNYCG VFRFRFWHFG EWKDVLIDDR LPTFRGRLIY IHSSNPTVFW AALLEKAYAK
LYGCYENLHL GFTTRAFQDL TGGIVQSFGL NNQEKYLTFQ VLNSAVPRST LIIASINPEK
ETKRQLRLRN GLLTQSAYSV TGLARVRNHL GEIPLVRLRN PWGKGDWTGP WSERSWEWEG
LNDRDKEILS TRAQNEGEFW MSFEDFVKNF THLDLVHVSP DDWMNEPALQ AKQPWRAVLA
RRRWRSGYNA GGSPIYIETT AVNPQFRIQI PRSSGNKCHV VVSVTQHYET YSIDNKKRKP
PFAIGFAVYE VPPTTVRLTQ NFVTEHKPLD VTNHSIAREV VTFFTLPPGD YIVVPQTNVP
NCDSKFLLRI FTDEQSNIWE VNEDNMVFRN ISTEYFEEAV ILPDGKPLIS KLLLKYPVEV
DAVQLQKILK SHWKAYLTEK PSLELCKSLI MLRDYNISGK INVSDIPILI HILQFWRMAF
QKLDKSHGNK TSSYNLRTLL WEAGTTVSNK VLECLVLRFS KNMVLTSECF VMAMVRLYLA
HERYHSLDTK MKKKGFKKVS HVFLM
//
