ID E0VN31_PEDHC Unreviewed; 4014 AA.
AC E0VN31;
DT 02-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2010, sequence version 1.
DT 27-MAR-2024, entry version 65.
DE SubName: Full=Dynein beta chain, ciliary, putative {ECO:0000313|EMBL:EEB14797.1, ECO:0000313|EnsemblMetazoa:PHUM327760-PA};
GN Name=8236250 {ECO:0000313|EnsemblMetazoa:PHUM327760-PA};
GN ORFNames=Phum_PHUM327760 {ECO:0000313|EMBL:EEB14797.1};
OS Pediculus humanus subsp. corporis (Body louse).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Paraneoptera; Psocodea; Phthiraptera; Anoplura; Pediculidae;
OC Pediculus.
OX NCBI_TaxID=121224;
RN [1] {ECO:0000313|EMBL:EEB14797.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=USDA {ECO:0000313|EMBL:EEB14797.1};
RA Kirkness E., Hannick L., Hass B., Bruggner R., Lawson D., Bidwell S.,
RA Joardar V., Caler E., Walenz B., Inman J., Schobel S., Galinsky K.,
RA Amedeo P., Strausberg R.;
RT "Annotation of Pediculus humanus corporis strain USDA.";
RL Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:EEB14797.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=USDA {ECO:0000313|EMBL:EEB14797.1};
RG The Human Body Louse Genome Consortium;
RA Kirkness E., Walenz B., Hass B., Bruggner R., Strausberg R.;
RT "The genome of the human body louse.";
RL Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EnsemblMetazoa:PHUM327760-PA}
RP IDENTIFICATION.
RC STRAIN=USDA {ECO:0000313|EnsemblMetazoa:PHUM327760-PA};
RG EnsemblMetazoa;
RL Submitted (FEB-2021) to UniProtKB.
CC -!- SIMILARITY: Belongs to the dynein heavy chain family.
CC {ECO:0000256|ARBA:ARBA00008887}.
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DR EMBL; AAZO01003806; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; DS235332; EEB14797.1; -; Genomic_DNA.
DR RefSeq; XP_002427535.1; XM_002427490.1.
DR STRING; 121224.E0VN31; -.
DR EnsemblMetazoa; PHUM327760-RA; PHUM327760-PA; PHUM327760.
DR GeneID; 8236250; -.
DR KEGG; phu:Phum_PHUM327760; -.
DR CTD; 8236250; -.
DR VEuPathDB; VectorBase:PHUM327760; -.
DR eggNOG; KOG3595; Eukaryota.
DR HOGENOM; CLU_000038_0_0_1; -.
DR InParanoid; E0VN31; -.
DR OMA; CIEWQRY; -.
DR OrthoDB; 166463at2759; -.
DR Proteomes; UP000009046; Unassembled WGS sequence.
DR GO; GO:0005929; C:cilium; IEA:UniProtKB-KW.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR Gene3D; 1.10.287.2620; -; 1.
DR Gene3D; 1.10.472.130; -; 1.
DR Gene3D; 1.10.8.1220; -; 1.
DR Gene3D; 1.10.8.710; -; 1.
DR Gene3D; 1.20.1270.280; -; 1.
DR Gene3D; 1.20.58.1120; -; 1.
DR Gene3D; 1.20.920.20; -; 1.
DR Gene3D; 1.20.920.30; -; 1.
DR Gene3D; 3.10.490.20; -; 1.
DR Gene3D; 6.10.140.1060; -; 1.
DR Gene3D; 1.20.140.100; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 5.
DR Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR InterPro; IPR035699; AAA_6.
DR InterPro; IPR035706; AAA_9.
DR InterPro; IPR041658; AAA_lid_11.
DR InterPro; IPR042219; AAA_lid_11_sf.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR041589; DNAH3_AAA_lid_1.
DR InterPro; IPR042222; Dynein_2_N.
DR InterPro; IPR043157; Dynein_AAA1S.
DR InterPro; IPR041466; Dynein_AAA5_ext.
DR InterPro; IPR041228; Dynein_C.
DR InterPro; IPR043160; Dynein_C_barrel.
DR InterPro; IPR024743; Dynein_HC_stalk.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR InterPro; IPR013602; Dynein_heavy_linker.
DR InterPro; IPR042228; Dynein_linker_3.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR45703; DYNEIN HEAVY CHAIN; 1.
DR PANTHER; PTHR45703:SF1; DYNEIN HEAVY CHAIN; 1.
DR Pfam; PF12774; AAA_6; 1.
DR Pfam; PF12775; AAA_7; 1.
DR Pfam; PF12780; AAA_8; 1.
DR Pfam; PF12781; AAA_9; 1.
DR Pfam; PF17857; AAA_lid_1; 1.
DR Pfam; PF18198; AAA_lid_11; 1.
DR Pfam; PF08393; DHC_N2; 1.
DR Pfam; PF17852; Dynein_AAA_lid; 1.
DR Pfam; PF18199; Dynein_C; 1.
DR Pfam; PF03028; Dynein_heavy; 1.
DR Pfam; PF12777; MT; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Cilium {ECO:0000256|ARBA:ARBA00023069};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Dynein {ECO:0000256|ARBA:ARBA00023017};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000009046}.
FT DOMAIN 733..1163
FT /note="Dynein heavy chain linker"
FT /evidence="ECO:0000259|Pfam:PF08393"
FT DOMAIN 1292..1618
FT /note="Dynein heavy chain hydrolytic ATP-binding dynein
FT motor region"
FT /evidence="ECO:0000259|Pfam:PF12774"
FT DOMAIN 1784..1923
FT /note="Dynein heavy chain AAA 5 extension"
FT /evidence="ECO:0000259|Pfam:PF17852"
FT DOMAIN 2144..2243
FT /note="Dynein heavy chain 3 AAA+ lid"
FT /evidence="ECO:0000259|Pfam:PF17857"
FT DOMAIN 2303..2562
FT /note="Dynein heavy chain AAA module D4"
FT /evidence="ECO:0000259|Pfam:PF12780"
FT DOMAIN 2579..2920
FT /note="Dynein heavy chain coiled coil stalk"
FT /evidence="ECO:0000259|Pfam:PF12777"
FT DOMAIN 2950..3171
FT /note="Dynein heavy chain ATP-binding dynein motor region"
FT /evidence="ECO:0000259|Pfam:PF12781"
FT DOMAIN 3416..3529
FT /note="Dynein heavy chain region D6 P-loop"
FT /evidence="ECO:0000259|Pfam:PF03028"
FT DOMAIN 3566..3705
FT /note="Dynein heavy chain AAA lid"
FT /evidence="ECO:0000259|Pfam:PF18198"
FT DOMAIN 3712..4010
FT /note="Dynein heavy chain C-terminal"
FT /evidence="ECO:0000259|Pfam:PF18199"
FT COILED 692..719
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2806..2868
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 4014 AA; 461156 MW; 91E606BABAEAAFCF CRC64;
MSQVNNSDDD FHIPFVFYGE DYSEWEGENL EIDETLFKKK ENEIQYKENL PEKSYNYQEN
NIIPLQKKFK PISFESPEIY ELVFNVLRIP NLPPVVMPNM DAYKCEEYSK SELFKFNLSS
KKTNIMFDYL QYVGIKKKIE IFYERILEED VEEIPKKKRH YELLLREYAS RLPTVPLQQE
WIDSILSKLY NLHVKFPFIA DKIMDEVKTN FYQSMHQFGI DAIMKCLPGQ NKKSFEIPID
DGEVGKTPRY HIFLMHRELI RSRLFILHKF QRKIYMLCVK LLPEWLVDIS KYRSLGFIDL
TKFNALFFAD LKKSEHIVTT SLYPKVVALV SRKRALNEFK ISARPKYLAS ATNILVVQVT
QLIQRSINRF IWATEDVERI PFLDLELVFD DGISLFPSEK TINNTFHNFI NAMANIAQQL
TSLEQWVDKV PVKSNFIKIA INESYLTEMH DKLDYNFDRL FEPVYNYMDA LDDEYNGLYS
AELVYEINSF IDENHSFEEV VEKREHFQGY VDKINDMVGN QYFNLCRLCQ EKLISSLRNF
AYAFCDDLLG EMIRTHGAVN LEICRTFEEV KARALKMPES SEEFMELGTY MVWANSTLMI
ELKEKITRQL FIVGRLIELT EIPTEYSNIM STTVNWLRDI KPIFDLNSSL YEQYKVEFED
RIHQRTERLN RQLEDLGPKL AILDNMDDIE RLPSYLEEIR KLLRDLEKFN DDVKWINKEE
AIFKFSISIY PELEELKNII VPFAKLLFTC HRWQRKYRLW MDGNFHDLNA EEVESTTEDF
HKEISKTLKV YKARIKQQIQ ENNPRKFKGN LDDPDPNMVP APIKICNKTL EQIKEFRTCI
QIVGILCNDA LTERHWDEMS EICGFDITPD FGTTLRKVVA MNLTEYLDRF EIISVGACKE
LQLSKNLQKM WAEWEGVKLQ TSFWKDTKIT ILSGLDDIQA LLDDHLVKTM TMRGSAFVKP
FEAEVKDWYE KLNRVNRTLE EWGKVQIQWL YLLPIFSSKD IVAQMPEEGH MFQEVDSVYK
RLMQSVTRDP LVLNCAGGTG VLEVLVDQTA SLEKINDGVN NYLEKKRLFF PRFFFLSNDE
MLEILSETKD PLRVQPHLRK CFEGISKLGF DSELNIFSMI SAEGEQIYIV STISTAEARG
SVEKWLLQVE EQMVITIRDV TERAYKAYLQ TDRNVWVKEW PGQIVICVST IYWTSEVHEQ
LSKGDVKHLK TYHDGLQVQL NQIVALVRGK LSKQNRVTLG ALVVIDVHAK DVVEELIETN
ITSDTDFSWL AQLRYYWEDD CMVRIINAVV KYAYEYLGNT PRLVITPLTD RCYRTLIGAY
HLHLNGAPEG PAGTGKTETT KDLAKALAVQ CVVFNCSDGL DYIAMGKFFK GLASSGAWAC
FDEFNRIELE VLSVIAQQIL CIMLAVQAGV KTFVFEGTEL VLNPACYVCI TMNPGYAGRS
ELPDNLKVLF RTVAMMVPDY ALIGEISLYS YGFVKARVLS VKIVTTYRLC SEQLSSQYHY
DYGMRAVKTV LQAAGNLKLK FQDENEDILL LRSIIDVNLP KFLRHDIPLF EGIISDLFPG
IVLPTPDYDD MLNVVDVVCK KKVLQPVESF KIKIIQTYEM MIVRHGFMLV GDPFGGKTST
LHVLADTLTI MNEKGFEEEK VQYVTINPKS ITMGQLYGQF DPVSYEWSDG IVATSFRGFV
QSETTDRKWI IFDGPVDAVW IENMNTVLDD NKKLCLNSGE VMAMTNVMSM IFEVMDLAQA
SPATVSRCGM IYLEPETLGW RPLVQSWITK QKGPWMEGNE NLIYDLYEWL IPPSLTFTRR
HCTFICNAGV ANRINSMMTI VQILLNDACA PEKKEKNQEV DLKNVNIWIQ AAFIYSGIWG
LGGGLDLQSR ATFNEFYLEM WKGTAAHPFP ESLGKVEISL PSDGLIHDHC YSFKGRGAWK
HWPEAMKTEK LVETINISQM LVPTVDTVKY QYLLELHIKH NFPTLLVGST GTGKSFYIQN
LLMYKLSQDL FVPAFITFTA SITANQTQEL VISKLNKKKK GRYGPPMGKK CVIFVDDMNM
PAKEVYGAQP PIELLRQYFD CKHWYDLKDT SKIFLFDTLF MGAMGLPGGS RQEIYARFLR
HFNIFAICDF SEESMIKIFT TVLFVGLKRN GFATDVMNSV SSIVHATMDM YQSAMNNLRP
TPAKSHYIFN LRDFARVIQG CSLVRKESAE SKKFFGKLWV HEILRVFYDR LIEDADRNWV
FDKIRLCVRE HLKENFDLLF DNLPLENNEC TQESLRDFMF GNYMDMDALE EERKYEEIPS
PDEFRDVALQ YMQDYNTSHK TKLDIVLFRY ALEHLSRICR ILAIPSGSGL LVGVSGSGRQ
SLCKLATVML SYNIFQPEIT NNYGMVSWRE DLKKVLREAG GKAKNTTFLF SEGQIKEESF
LLDIDALLNS GEVPNLFAID EKQEILEMVR LAAQGGNRNL DISPLAVFSF FISRCKQKLH
VMLCLSPIGS SFRNRLRLYP SFVNCCTIDW FVDWPEDALE MIGIKWMKDV HLSEEIKSVA
TLACKHFHVT AKKLSDEFYQ KTNRKTYITS SAFLELIKCF THFTNSKQDE IMAAKMRYVG
GLEKLDFAAA QVAEMSNELS ALKPKLVIAA KETLEMMETI EKETIKVERV TELVKEDEKV
ANVQAAAAAE LKVECEADLA EAVPILEEAI AALNTLKPTD ITLVKSMKNP PDTVKLVMAA
VCVMKNVKPD RITDPTTGKK ILNYWGPSKR ILGEMTFLQS LKEYDKDNIP EEIMNKIRKE
YLPHKDFKPS VVAKASSAAE GLCKWIIAMD LYDAVAKEVA PKKAKLQIAE TEFAKTMELL
DQKKAQVTKL ESELNELKDK LKNAQDQKQA LEDEVNLCSN KLTRAEKLIG GLGGEKSRWS
AAADSLQNYY DCLAGDILIS CAIIAYLSPF TMNYRMEKIQ EWQSHVKSLN IPASDEYVFS
KIMGSDIKIQ SWNIYGLPRD QFSSDNAIIM DNSRRWSLFL DPQNQANKWV KAMEKSNDLK
VCKFSDSNYM KIVEMCIETG RPVLIENILE ELEAPIEPLL NNNTFQQGGR LYMALGDNVI
EYNPKFLLYM TSKLRNPHYL PEVFNKVTVI NFSLTIDGLE DQLLGIVVAK ERPDLQETRQ
ELIVQSANNK KALVDVEDMI LKTLSETKGN ILENESAIEV LDSSKILSLE ILEKQEAAKE
TEQMIESFRL NYRPIASHSA VLYYCVTDLP NVDPMYQYSL GWFINLYVMS IETANKSKLL
EKRLAFLHET FTYNLYSNVC RSLFEKDKLL FSLLLCCNVM MSKKTLTKTE FMFLITGGVG
LKNPLPNPAS SWLSGKSWDE LCRVNEIPGF KGIVDHFIKF SKEWQQFYDL PDPTYDNIPA
SWRNKLTDFK NLMLIRIFRP DKILINVSKF VEAELGTKFT RPPTFDISKS YNDSNCLCPL
IFILSPGADP MRALTKFSQK KGMVTKFQSI SLGQGQGPIA AKMIEQAQID GDWVCLQNCH
LAVSWMPALE KIWEGLDTSN TALTFRLWLT SYPSDKFPAS ILQYGVKMTN EPPTGLQPNL
ARSYSSEPVK DPEFFEGCPG KDKIFGKLLY GICFFHAIVQ ERRKYGAIGW NIPYGFNESD
FQISVKQLQM FLNEYDYVPY KAITYLTGEC NYGGRVTDDW DRRCLITILS DFVNPNVVSD
PGYTFCPLGP AYGLPRKTEY RDYVNHINNI PSVPPPEVFG LHTNAGITRD LQNAKNLLSS
LLLVQGESTG GDSSSDALLY DIAKDILSKL PPNFDLELAL EKFPVTYTES MNTVLVQEME
RFNKLLSVIR TTLQSIQKAI KGLVVMTPAL DMIAANIQYA KVPAAWAKVS YPSLKKLGSY
VNDFLERLAF LKRWHDAGKP PQFWLSGFFF TQAFLTGAMQ NFARKYTIPI DQLTFDFEVT
NLGKIAKPPI DGVYIYGLFV DGARWDRKAG NLEEQFFKIL YDVLPVVWLK PIEKIKLQEK
GRYKSPLYKT SERRGVLSTT GHSTNYVLPF LLDTKKPVSH WIKRGTALLC QLDD
//
